Beyond oxidative stress: an immunologist’s guide to reactive oxygen species
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TLDR
ROS chemistry and their pleiotropy make them difficult to localize, to quantify and to manipulate — challenges the authors must overcome to translate ROS biology into medical advances.Abstract:
Reactive oxygen species (ROS) react preferentially with certain atoms to modulate functions ranging from cell homeostasis to cell death. Molecular actions include both inhibition and activation of proteins, mutagenesis of DNA and activation of gene transcription. Cellular actions include promotion or suppression of inflammation, immunity and carcinogenesis. ROS help the host to compete against microorganisms and are also involved in intermicrobial competition. ROS chemistry and their pleiotropy make them difficult to localize, to quantify and to manipulate — challenges we must overcome to translate ROS biology into medical advances.read more
Citations
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Journal ArticleDOI
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents.
Helmut Sies,Dean P. Jones +1 more
TL;DR: This work focuses on ROS at physiological levels and their central role in redox signalling via different post-translational modifications, denoted as ‘oxidative eustress’.
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Oxidative stress: a concept in redox biology and medicine.
TL;DR: “Oxidative stress” as a concept in redox biology and medicine has been formulated in 1985; at the beginning of 2015, approx.
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Delivery technologies for cancer immunotherapy
TL;DR: How recent developments in drug delivery could enable new cancer immunotherapies and improve on existing ones are discussed, and the current delivery obstacles are examined.
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Reactive Oxygen Species (ROS)-Based Nanomedicine.
Bowen Yang,Yu Chen,Jianlin Shi +2 more
TL;DR: In this article, the intrinsic biochemical properties of reactive oxygen species (ROS) underlie the mechanisms that regulate various physiological functions of living organisms, and they play an essential role in regulating various physiological function.
Journal ArticleDOI
Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress.
TL;DR: The present overview focuses on recent progress on metabolic sources and sinks of H 2O2 and on the role of H2O2 in redox signaling under physiological conditions, denoted as oxidative eustress.
References
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Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
Robert D. Guzy,Beatrice Hoyos,Emmanuel Robin,Hong Chen,Liping Liu,Liping Liu,Kyle D. Mansfield,M. Celeste Simon,M. Celeste Simon,Ulrich Hämmerling,Paul T. Schumacker +10 more
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A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish
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ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis.
Kaori Ishikawa,Kaori Ishikawa,Keizo Takenaga,Miho Akimoto,Nobuko Koshikawa,Aya Yamaguchi,Hirotake Imanishi,Kazuto Nakada,Yoshio Honma,Jun-Ichi Hayashi +9 more
TL;DR: It is indicated that mtDNA mutations can contribute to tumor progression by enhancing the metastatic potential of tumor cells by using cytoplasmic hybrid technology.
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Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells.
Keisuke Ito,Atsushi Hirao,Atsushi Hirao,Fumio Arai,Keiyo Takubo,Sahoko Matsuoka,Kana Miyamoto,Masako Ohmura,Masako Ohmura,Kazuhito Naka,Kentaro Hosokawa,Yasuo Ikeda,Toshio Suda +12 more
TL;DR: In this paper, the authors show that activation of p38 MAPK in response to increasing levels of reactive oxygen species (ROS) limits the lifespan of HSCs in vivo.
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TLR signalling augments macrophage bactericidal activity through mitochondrial ROS
A. Phillip West,Igor E. Brodsky,Igor E. Brodsky,Christoph Rahner,Dong Kyun Woo,Hediye Erdjument-Bromage,Paul Tempst,Matthew C. Walsh,Yongwon Choi,Gerald S. Shadel,Siddhartha Sankar Ghosh +10 more
TL;DR: It is demonstrated that engagement of a subset of Toll-like receptors results in the recruitment of mitochondria to macrophage phagosomes and augments mROS production, revealing a novel pathway linking innate immune signalling to mitochondria, implicate mR OS as an important component of antibacterial responses and further establish mitochondria as hubs for innate immune signaling.