Beyond oxidative stress: an immunologist’s guide to reactive oxygen species
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TLDR
ROS chemistry and their pleiotropy make them difficult to localize, to quantify and to manipulate — challenges the authors must overcome to translate ROS biology into medical advances.Abstract:
Reactive oxygen species (ROS) react preferentially with certain atoms to modulate functions ranging from cell homeostasis to cell death. Molecular actions include both inhibition and activation of proteins, mutagenesis of DNA and activation of gene transcription. Cellular actions include promotion or suppression of inflammation, immunity and carcinogenesis. ROS help the host to compete against microorganisms and are also involved in intermicrobial competition. ROS chemistry and their pleiotropy make them difficult to localize, to quantify and to manipulate — challenges we must overcome to translate ROS biology into medical advances.read more
Citations
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Interactions between sublethal doses of thiamethoxam and Nosema ceranae in the honey bee, Apis mellifera†
TL;DR: A clear combined effect of thiamethoxam and Nosema is shown, but mainly in worker mortality and very little effect on gene expression is shown in honey bee survival and expression changes of immune and detoxification genes.
Dissertation
Porphyrinic-nanoplatforms: controlled intracellular generation of reactive oxygen species in human mesenchymal stem cells
TL;DR: The developed porphyrinic nanoplatforms have the potential to be applied as a tool to investigate the cellular mechanisms and metabolism associated with different levels of oxidative stress and could also represent an innovative platform for theranostic applications (drug delivery/diagnostic).
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A sensor at the lipid-protein interface: Lipid peroxidation controls hepatitis C virus replication
TL;DR: It is shown that multiple hepatitis C virus (HCV) genotypes are exquisitely sensitive to oxidative membrane damage, a property distinguishing them from other pathogenic RNA viruses, and the typical, wild-type HCV replicase is uniquely regulated by lipid peroxidation.
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Expression Regulation, Protein Chemistry and Functional Biology of the Guanine-Rich Sequence Binding Factor 1 (GRSF1)
TL;DR: In eukaryotic cells RNA-binding proteins have been implicated in virtually all post-transcriptional mechanisms of gene expression regulation, based on the structural features of their RNA binding domains as discussed by the authors.
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Distinct responses of Pseudomonas aeruginosa PAO1 exposed to different levels of polystyrene nanoplastics.
TL;DR: In this article , multiple responses of Pseudomonas aeruginosa PAO1 (PAO1) to different levels of polystyrene nanoplastics exposure were investigated by physiological experiments, live/dead staining, redox status, and genome-wide RNA sequencing.
References
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Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN)
Joe M. McCord,Irwin Fridovich +1 more
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