Beyond oxidative stress: an immunologist’s guide to reactive oxygen species
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TLDR
ROS chemistry and their pleiotropy make them difficult to localize, to quantify and to manipulate — challenges the authors must overcome to translate ROS biology into medical advances.Abstract:
Reactive oxygen species (ROS) react preferentially with certain atoms to modulate functions ranging from cell homeostasis to cell death. Molecular actions include both inhibition and activation of proteins, mutagenesis of DNA and activation of gene transcription. Cellular actions include promotion or suppression of inflammation, immunity and carcinogenesis. ROS help the host to compete against microorganisms and are also involved in intermicrobial competition. ROS chemistry and their pleiotropy make them difficult to localize, to quantify and to manipulate — challenges we must overcome to translate ROS biology into medical advances.read more
Citations
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Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils
Delphine Ohayon,Delphine Ohayon,Alessia De Chiara,Alessia De Chiara,Pham My-Chan Dang,Pham My-Chan Dang,Nathalie Thieblemont,Nathalie Thieblemont,Simon Chatfield,Simon Chatfield,Viviana Marzaioli,Viviana Marzaioli,Sabrina Sofia Burgener,Julie Mocek,Julie Mocek,Céline Candalh,Céline Candalh,Coralie Pintard,Coralie Pintard,Pascale Tacnet-Delorme,Gilles Renault,Gilles Renault,Isabelle Lagoutte,Isabelle Lagoutte,Maryline Favier,Maryline Favier,Francine Walker,Margarita Hurtado-Nedelec,Margarita Hurtado-Nedelec,Dominique Desplancq,Etienne Weiss,Charaf Benarafa,Dominique Housset,Jean-Claude Marie,Jean-Claude Marie,Philippe Frachet,Jamel El-Benna,Jamel El-Benna,Véronique Witko-Sarsat,Véronique Witko-Sarsat +39 more
TL;DR: A novel function of cytosolic proliferating cell nuclear antigen (PCNA) in the control of neutrophil NADPH oxidase, a complex pivotal for ROS generation in inflammation is described.
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Ultrasound controlled mechanophore activation in hydrogels for cancer therapy
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References
More filters
Journal ArticleDOI
Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN)
Joe M. McCord,Irwin Fridovich +1 more
TL;DR: The demonstration that O2·- can reduce ferricytochrome c and tetranitromethane, and that superoxide dismutase, by competing for the superoxide radicals, can markedly inhibit these reactions, is demonstrated.
Journal ArticleDOI
Myeloid-derived suppressor cells as regulators of the immune system.
TL;DR: The origin, mechanisms of expansion and suppressive functions of MDSCs, as well as the potential to target these cells for therapeutic benefit are discussed.
Journal ArticleDOI
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
Journal ArticleDOI
A role for mitochondria in NLRP3 inflammasome activation
TL;DR: It is shown that mitophagy/autophagy blockade leads to the accumulation of damaged, ROS-generating mitochondria, and this in turn activates the NLRP3 inflammasome, and may explain the frequent association of mitochondrial damage with inflammatory diseases.
Journal ArticleDOI
Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent.
TL;DR: O(2) (-) is made by leukocytes under circumstances which suggest that it may be involved in bacterial killing, and is identified as the agent responsible for the leukocyte-mediated reduction of cytochrome c.