Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack.
Chamutal Gur,Yara Ibrahim,Batya Isaacson,Rachel Yamin,Jawad Abed,Moriya Gamliel,Jonatan Enk,Yotam Bar-On,Noah Stanietsky-Kaynan,Shunit Coppenhagen-Glazer,Noam Shussman,Gideon Almogy,Angelica Cuapio,Erhard Hofer,Dror Mevorach,Adi Tabib,Rona Ortenberg,Gal Markel,Karmela Miklić,Stipan Jonjić,Caitlin A. Brennan,Wendy S. Garrett,Gilad Bachrach,Ofer Mandelboim +23 more
TLDR
This work has shown that natural killer cell killing of various tumors is inhibited in the presence of various F. nucleatum strains, and identified a bacterium-dependent, tumor-immune evasion mechanism in which tumors exploit the Fap2 protein of F. nucleus to inhibit immune cell activity via TIGIT.About:
This article is published in Immunity.The article was published on 2015-02-17 and is currently open access. It has received 784 citations till now. The article focuses on the topics: TIGIT & Fusobacterium nucleatum.read more
Citations
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Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation
TL;DR: Co-inhibitory receptors, such as CTLA-4 and PD-1, have an important role in regulating T cell responses and have proven to be effective targets in the setting of chronic diseases where constitutive co- inhibitory receptor expression on T cells dampens effector T-cell responses.
Journal ArticleDOI
Interaction between microbiota and immunity in health and disease
TL;DR: In this paper, the authors review features of microbiome-immunity crosstalk and their roles in health and disease, while providing examples of molecular mechanisms orchestrating these interactions in the intestine and extra-intestinal organs.
Journal ArticleDOI
Cancer and the microbiota
TL;DR: This Review considers how microbes and the microbiota may amplify or mitigate carcinogenesis, responsiveness to cancer therapeutics, and cancer-associated complications.
Journal ArticleDOI
Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer
Susan Bullman,Susan Bullman,Chandra Sekhar Pedamallu,Chandra Sekhar Pedamallu,Ewa Sicinska,Thomas E. Clancy,Xiaoyang Zhang,Xiaoyang Zhang,Diana Cai,Diana Cai,Donna Neuberg,Katherine H. Huang,Fatima Guevara,Timothy Nelson,Otari Chipashvili,Timothy Hagan,Mark Walker,Aruna Ramachandran,Aruna Ramachandran,Begoña Diosdado,Begoña Diosdado,Garazi Serna,Nuria Mulet,Stefania Landolfi,Santiago Ramón y Cajal,Roberta Fasani,Andrew J. Aguirre,Andrew J. Aguirre,Andrew J. Aguirre,Kimmie Ng,Elena Elez,Shuji Ogino,Shuji Ogino,Josep Tabernero,Charles S. Fuchs,William C. Hahn,William C. Hahn,William C. Hahn,Paolo Nuciforo,Matthew Meyerson,Matthew Meyerson,Matthew Meyerson +41 more
TL;DR: Col colonization of human colorectal cancers with Fusobacterium and its associated microbiome—including Bacteroides, Selenomonas, and Prevotella species—is maintained in distal metastases, demonstrating microbiome stability between paired primary and metastatic tumors.
Journal ArticleDOI
Molecular principles of metastasis: a hallmark of cancer revisited
Jawad Fares,Jawad Fares,Mohamad Y. Fares,Mohamad Y. Fares,Hussein H. Khachfe,Hussein H. Khachfe,Hamza A. Salhab,Hamza A. Salhab,Youssef Fares +8 more
TL;DR: The authors explore the recent advancements in the field of metastasis and highlight the latest insights that contribute to shaping this hallmark of cancer.
References
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Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
Noa Stanietsky,Hrvoje Šimić,Jurica Arapović,Amir Toporik,Ofer Levy,Amit Novik,Zurit Levine,Meirav Beiman,Liat Dassa,Hagit Achdout,Noam Stern-Ginossar,Pinhas Tsukerman,Stipan Jonjić,Ofer Mandelboim +13 more
TL;DR: It is shown that TIGIT is expressed by all human NK cells, that it binds PVR and PVRL2 but not PVRL3 and that it inhibits NK cytotoxicity directly through its ITIM, providing an “alternative self” mechanism for MHC class I inhibition.
Journal ArticleDOI
Innate or Adaptive Immunity? The Example of Natural Killer Cells
Eric Vivier,David H. Raulet,Alessandro Moretta,Michael A. Caligiuri,Laurence Zitvogel,Lewis L. Lanier,Wayne M. Yokoyama,Sophie Ugolini,Sophie Ugolini +8 more
TL;DR: NK cells are now recognized to express a repertoire of activating and inhibitory receptors that is calibrated to ensure self-tolerance while allowing efficacy against assaults such as viral infection and tumor development.
Journal ArticleDOI
Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment
Aleksandar Kostic,Aleksandar Kostic,Eunyoung Chun,Lauren Robertson,Jonathan N. Glickman,Carey Ann Gallini,Monia Michaud,Thomas E. Clancy,Thomas E. Clancy,Daniel C. Chung,Paul Lochhead,Georgina L. Hold,Emad M. El-Omar,Dean E. Brenner,Charles S. Fuchs,Matthew Meyerson,Matthew Meyerson,Wendy S. Garrett +17 more
TL;DR: Data suggest that, through recruitment of tumor-infiltrating immune cells, fusobacteria generate a proinflammatory microenvironment that is conducive for colorectal neoplasia progression, and this work finds that F.nucleatum does not exacerbate colitis, enteritis, or inflammation-associated intestinal carcinogenesis.
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