Journal ArticleDOI
Biodegradable polymeric nanoparticles as drug delivery devices
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This review presents the most outstanding contributions in the field of biodegradable polymeric nanoparticles used as drug delivery systems from 1990 through mid-2000.About:
This article is published in Journal of Controlled Release.The article was published on 2001-01-29. It has received 3284 citations till now. The article focuses on the topics: Drug carrier & Drug delivery.read more
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Hybrid porous solids: past, present, future
TL;DR: The state-of-the-art on hybrid porous solids, their advantages, their new routes of synthesis, the structural concepts useful for their 'design', aiming at reaching very large pores are presented.
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Electrospinning: A Fascinating Method for the Preparation of Ultrathin Fibers
TL;DR: Electrospinning is a highly versatile method to process solutions or melts, mainly of polymers, into continuous fibers with diameters ranging from a few micrometers to a few nanometers, applicable to virtually every soluble or fusible polymer.
Journal ArticleDOI
Biodegradable polymeric nanoparticles based drug delivery systems
TL;DR: The impact of nanoencapsulation of various disease related drugs on biodegradable nanoparticles such as PLGA, PLA, chitosan, gelatin, polycaprolactone and poly-alkyl-cyanoacrylates is highlighted.
Journal ArticleDOI
PLGA-based nanoparticles: An overview of biomedical applications
Fabienne Danhier,Eduardo Ansorena,Joana M. Silva,Joana M. Silva,Régis Coco,Aude Le Breton,Véronique Préat +6 more
TL;DR: This review presents why PLGA has been chosen to design nanoparticles as drug delivery systems in various biomedical applications such as vaccination, cancer, inflammation and other diseases.
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Recent advances on chitosan-based micro- and nanoparticles in drug delivery.
TL;DR: The present review outlines the major new findings on the pharmaceutical applications of chitosan-based micro/nanoparticulate drug delivery systems published over the past decade and discusses critically the usefulness of these systems in delivering the bioactive molecules.
References
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Journal ArticleDOI
Uptake of surfactant-coated poly(methyl methacrylate)-nanoparticles by bovine brain microvessel endothelial cell monolayers
TL;DR: The objective of this study was to determine the influence of coating of radiolabeled poly(methylmethacrylate) nanoparticles (PMMA nanoparticles) with surfactants on their uptake by bovine microvessel endothelial cell cultures (BMEC cultures).
Journal ArticleDOI
Kinetics of blood component adsorption on poly(D,L-lactic acid) nanoparticles: evidence of complement C3 component involvement.
TL;DR: Adsorption of complement C3 components onto the surface of the nanoparticles was clearly evidenced by spots of increasing intensity and area, reaching levels comparable to those of the omnipresent IgG, which confirms the important role of complement components in the opsonization process of poly(D,L-lactic acid) particles.
Nanoparticle characterization : a comprehensive physicochemical approach
B. Magenheim,Simon Benita +1 more
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Efficacy of Oral Dalargin-loaded Nanoparticle Delivery across the Blood-Brain Barrier
TL;DR: The data support the usefulness of nanoparticles as a method to deliver drugs to the brain by showing that analgesia was observable after intravenously and oral application even when nanoparticles were not coated.
Journal ArticleDOI
Surface modification of i.v. injectable biodegradable nanoparticles with poloxamer polymers and poloxamine 908
Rainer H. Müller,K.H. Wallis +1 more
TL;DR: In this article, the particle surface was modified by using different stabilizers in the solvent evaporation process, which resulted in coating layers up to 10 nm and distinctly increased surface hydrophilicity of the particles.
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