Journal ArticleDOI
Biodegradable polymeric nanoparticles as drug delivery devices
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TLDR
This review presents the most outstanding contributions in the field of biodegradable polymeric nanoparticles used as drug delivery systems from 1990 through mid-2000.About:
This article is published in Journal of Controlled Release.The article was published on 2001-01-29. It has received 3284 citations till now. The article focuses on the topics: Drug carrier & Drug delivery.read more
Citations
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Novel ultra-rapid freezing particle engineering process for enhancement of dissolution rates of poorly water-soluble drugs
Kirk Overhoff,Josh D. Engstrom,Bo Chen,Brian D. Scherzer,Thomas E. Milner,Keith P. Johnston,Robert O. Williams +6 more
TL;DR: An understanding is provided of how the solvent's physical properties and the thin film geometry influence the freezing rate and consequently the final physico-chemical properties of URF-processed powders.
Journal ArticleDOI
Advanced Materials for Co‐Delivery of Drugs and Genes in Cancer Therapy
TL;DR: Key advances in drug and gene delivery are summarized with focus on the development of polymers, peptides, liposomes and inorganic materials as nanocarriers for co‐delivery of small molecular drugs and macromolecular genes or proteins.
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Nanoparticles-mediated drug delivery approaches for cancer targeting: a review.
TL;DR: The article highlights recent developments in “smart”-stimulus-responsive-drug carriers designed to enhance the localization and efficacy of therapeutic payloads as compared with free drug.
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Spray-dried indomethacin-loaded polyester nanocapsules and nanospheres: development, stability evaluation and nanostructure models.
Adriana Raffin Pohlmann,Valeria Weiss,Omar Mertins,Nádya Pesce da Silveira,Silvia Stanisçuaski Guterres +4 more
TL;DR: The dynamic properties of these systems allowed to suggest that the structure of the nanosphere particle was a polymeric matrix dispersing the sorbitan monostearate which, when submitted to the spray-drying process in the presence of SiO(2), gave nanostructures presenting diameters around 80 nm covering the microparticles due to the release of lipophilic surfactant from thepolymeric matrix.
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Indomethacin-loaded nanocapsules treatment reduces in vivo glioblastoma growth in a rat glioma model
Andressa Bernardi,Elizandra Braganhol,Eliézer Jäger,Fabrício Figueiró,Maria Isabel Albano Edelweiss,Adriana Raffin Pohlmann,Silvia Stanisçuaski Guterres,Ana Maria Oliveira Battastini +7 more
TL;DR: Results show that polymeric nanocapsules are able to increase the intratumoral bioavailability of indomethacin and reduce the growth of implanted gliomas and suggest that indometHacin-loaded nanocapules could offer new and potentially highly effective strategies for the treatment of malignant glioma.
References
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Journal ArticleDOI
Biodegradable long-circulating polymeric nanospheres
Ruxandra Gref,Yoshiharu Minamitake,Maria Teresa Peracchia,Vladimir S. Trubetskoy,Vladimir P. Torchilin,Robert Langer +5 more
TL;DR: Monodisperse biodegradable nanospheres were developed from amphiphilic copolymers composed of two biocompatible blocks and exhibited dramatically increased blood circulation times and reduced liver accumulation in mice.
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Polymeric Systems for Controlled Drug Release
TL;DR: Kevin Shakesheff investigates new methods of engineering polymer surfaces and the application of these engineered materials in drug delivery and tissue engineering.
Journal ArticleDOI
Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers
TL;DR: In this paper, a new approach for the preparation of nanoparticles made solely of hydrophilic polymers is presented, based on an ionic gelation process, is extremely mild and involves the mixture of two aqueous phases at room temperature.
Journal ArticleDOI
Protein—surface interactions in the presence of polyethylene oxide
TL;DR: In this paper, the steric repulsion free energy and van der Waals attraction free energy of polyethylene oxide (PEO) chains were calculated as a function of surface density and chain length of PEO.
Book
Principles of tissue engineering
TL;DR: The history and Scope of Tissue Engineering, J.P. Vavanti and C.A. Vacanti, and Quantitative Aspects of Tissues Engineering: Basic Issues in Kinetics, Transport, and Mechanics are reviewed.
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