Journal ArticleDOI
Biodegradable polymeric nanoparticles as drug delivery devices
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TLDR
This review presents the most outstanding contributions in the field of biodegradable polymeric nanoparticles used as drug delivery systems from 1990 through mid-2000.About:
This article is published in Journal of Controlled Release.The article was published on 2001-01-29. It has received 3284 citations till now. The article focuses on the topics: Drug carrier & Drug delivery.read more
Citations
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In vitro, in vivo and pharmacokinetic assessment of amikacin sulphate laden polymeric nanoparticles meant for controlled ocular drug delivery
Upendra Kumar Sharma,Upendra Kumar Sharma,Upendra Kumar Sharma,Amita Verma,S. K. Prajapati,Himanshu Pandey,Himanshu Pandey,Avinash C. Pandey,Avinash C. Pandey +8 more
TL;DR: Positive charged amikacin-loaded polymeric nanoparticles providing a controlled release attribute reflected a better fit with Korsmeyer–Peppas model and displays the most prominent inhibitory effect against S. aureus.
Journal ArticleDOI
Stroke Management: An Emerging Role of Nanotechnology
Deepaneeta Sarmah,Jackson Saraf,Harpreet Kaur,Kanta Pravalika,Rakesh K. Tekade,Anupom Borah,Kiran Kalia,Kunjan R. Dave,Pallab Bhattacharya +8 more
TL;DR: Nanotechnology is a growing field, offering an encouraging future prospect for medical research in the management of strokes, and several obstacles remain to be overcome when using such nanomaterials for treating stroke and other neurological diseases.
Journal ArticleDOI
Adsorption of obidoxime onto human serum albumin nanoparticles: Drug loading, particle size and drug release
TL;DR: The in vitro release of obidoxime from HSA nanoparticles showed a rapid release of the drug from the nanoparticles within 3 h, and at higher concentrations the particle diameter increased significantly with obdoxime concentration leading to instable particle systems.
Journal ArticleDOI
Branched amphiphilic peptide capsules: cellular uptake and retention of encapsulated solutes.
Pinakin Sukthankar,L. Adriana Avila,Susan K. Whitaker,Takeo Iwamoto,Alfred Morgenstern,Christos Apostolidis,Ke Liu,Robert P. Hanzlik,Ekaterina Dadachova,John M. Tomich +9 more
TL;DR: The ability of the constructs to retain alpha particle emitting radionuclides without any apparent leakage and their persistence in the peri-nuclear region of the cell for extended periods of time makes them attractive as biocompatible carriers for targeted cancer therapy using particle emitting radioisotopes.
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Adsorption, Desorption, and Removal of Polymeric Nanomedicine on and from Cellulose Surfaces: Effect of Size
Ming Zhang,Mustafa Akbulut +1 more
TL;DR: Hydrodynamic forces acting parallel to the surfaces are found to be of great importance in the context of particle dynamics near the cellulose surface, and ultimately responsible for the removal of some fraction of particles via rolling or sliding.
References
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Journal ArticleDOI
Biodegradable long-circulating polymeric nanospheres
Ruxandra Gref,Yoshiharu Minamitake,Maria Teresa Peracchia,Vladimir S. Trubetskoy,Vladimir P. Torchilin,Robert Langer +5 more
TL;DR: Monodisperse biodegradable nanospheres were developed from amphiphilic copolymers composed of two biocompatible blocks and exhibited dramatically increased blood circulation times and reduced liver accumulation in mice.
Journal ArticleDOI
Polymeric Systems for Controlled Drug Release
TL;DR: Kevin Shakesheff investigates new methods of engineering polymer surfaces and the application of these engineered materials in drug delivery and tissue engineering.
Journal ArticleDOI
Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers
TL;DR: In this paper, a new approach for the preparation of nanoparticles made solely of hydrophilic polymers is presented, based on an ionic gelation process, is extremely mild and involves the mixture of two aqueous phases at room temperature.
Journal ArticleDOI
Protein—surface interactions in the presence of polyethylene oxide
TL;DR: In this paper, the steric repulsion free energy and van der Waals attraction free energy of polyethylene oxide (PEO) chains were calculated as a function of surface density and chain length of PEO.
Book
Principles of tissue engineering
TL;DR: The history and Scope of Tissue Engineering, J.P. Vavanti and C.A. Vacanti, and Quantitative Aspects of Tissues Engineering: Basic Issues in Kinetics, Transport, and Mechanics are reviewed.
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