Journal ArticleDOI
Biodegradable polymeric nanoparticles as drug delivery devices
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TLDR
This review presents the most outstanding contributions in the field of biodegradable polymeric nanoparticles used as drug delivery systems from 1990 through mid-2000.About:
This article is published in Journal of Controlled Release.The article was published on 2001-01-29. It has received 3284 citations till now. The article focuses on the topics: Drug carrier & Drug delivery.read more
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Recent Status of Nanomaterial Fabrication and Their Potential Applications in Neurological Disease Management
TL;DR: The present review elucidates the importance of frequently used metal chelators, NMs and/or NPs in drug delivery for neurological disease management and discusses the current status and future challenges.
Journal ArticleDOI
Preparation and Characterization of Microcapsules Based on Biodegradable Polymers: Pectin/Casein Complex for Controlled Drug Release Systems
Marcela M. Baracat,Adriana M. Nakagawa,Rubia Casagrande,Sandra R. Georgetti,Waldiceu A. Verri,Osvaldo de Freitas +5 more
TL;DR: The polymeric system present herein seemed to be appropriate for a prolonged release of acetaminophen throughout the gastrointestinal tract, and it is likely that it is a promising pectin/casein complex for lipossoluble drugs, which merits further investigation.
Journal ArticleDOI
Effects of curcumin-loaded PLGA nanoparticles on the RG2 rat glioma model.
Merdan Orunoğlu,Abbas Kaffashi,Sibel Bozdağ Pehlivan,Selma Sahin,Figen Soylemezoglu,Kader Karli Oguz,Melike Mut +6 more
TL;DR: In this in vivo experimental model, intratumoral administration of curcumin-loaded PLGA-DSPE-PEG hybrid nanoparticles was effective against glioblastoma andCurcumine-loaded nanoparticles may have potential application in chemotherapy of gliOBlastoma.
Journal ArticleDOI
Antigen presentation on artificial acellular substrates: modular systems for flexible, adaptable immunotherapy.
TL;DR: Acellular aAPCs are a powerful alternative to natural-cell-based therapies, offering flexibility and modularity for incorporation oSf a variety of stimuli, hence increasing precision.
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Targeting of injectable drug nanocrystals
TL;DR: "nano" creates both opportunities and challenges for targeted drug delivery, which are critically discussed in both in vitro and in vivo settings in this contribution.
References
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Journal ArticleDOI
Biodegradable long-circulating polymeric nanospheres
Ruxandra Gref,Yoshiharu Minamitake,Maria Teresa Peracchia,Vladimir S. Trubetskoy,Vladimir P. Torchilin,Robert Langer +5 more
TL;DR: Monodisperse biodegradable nanospheres were developed from amphiphilic copolymers composed of two biocompatible blocks and exhibited dramatically increased blood circulation times and reduced liver accumulation in mice.
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Polymeric Systems for Controlled Drug Release
TL;DR: Kevin Shakesheff investigates new methods of engineering polymer surfaces and the application of these engineered materials in drug delivery and tissue engineering.
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Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers
TL;DR: In this paper, a new approach for the preparation of nanoparticles made solely of hydrophilic polymers is presented, based on an ionic gelation process, is extremely mild and involves the mixture of two aqueous phases at room temperature.
Journal ArticleDOI
Protein—surface interactions in the presence of polyethylene oxide
TL;DR: In this paper, the steric repulsion free energy and van der Waals attraction free energy of polyethylene oxide (PEO) chains were calculated as a function of surface density and chain length of PEO.
Book
Principles of tissue engineering
TL;DR: The history and Scope of Tissue Engineering, J.P. Vavanti and C.A. Vacanti, and Quantitative Aspects of Tissues Engineering: Basic Issues in Kinetics, Transport, and Mechanics are reviewed.
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