Journal ArticleDOI
Biodegradable polymeric nanoparticles as drug delivery devices
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TLDR
This review presents the most outstanding contributions in the field of biodegradable polymeric nanoparticles used as drug delivery systems from 1990 through mid-2000.About:
This article is published in Journal of Controlled Release.The article was published on 2001-01-29. It has received 3284 citations till now. The article focuses on the topics: Drug carrier & Drug delivery.read more
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Novel protein-loaded chondroitin sulfate-chitosan nanoparticles: Preparation and characterization
TL;DR: In this paper, the potential of chondroitin sulfate (ChS)-chitosan (CS) nanoparticles for the delivery of proteins was investigated by ionic cross-linking of CS solution with ChS.
Journal ArticleDOI
Challenges and Opportunities in the Clinical Development of STING Agonists for Cancer Immunotherapy.
TL;DR: The body of evidence supporting a synergistic role of STING agonists with currently approved ICI therapies is summarized and whether, despite the numerous obstacles encountered to date, the clinical development of STing agonist as novel anti-cancer therapeutics may still hold the promise of broadening the reach of cancer immunotherapy is discussed.
Journal ArticleDOI
Nisin-loaded poly-l-lactide nano-particles produced by CO2 anti-solvent precipitation for sustained antimicrobial activity
TL;DR: In vitro studies carried out by nano-particle incubation in medium containing Lactobacillus delbrueckeii showed that nisin was released in the active form and the antibacterial activity was maintained up to 45 days incubation.
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Recent Progress on Nanostructures for Drug Delivery Applications
TL;DR: The driving forces for the self-assembly of nanostructures are introduced and a variety of nanstructures fabricated from various building materials, mainly liposomes, polymers, ceramics, metal, peptides, nucleic acids, and even drugs themselves are discussed.
Journal ArticleDOI
Amphiphilic PHA-mPEG copolymeric nanocontainers for drug delivery: preparation, characterization and in vitro evaluation.
TL;DR: The in vitro cytotoxicity evaluation of the nanoparticles on prenatal rat neuronal hippocampal and fibroblast cells revealed that biocompatibility of the amphiphilic nanoparticles was generally independent of the ratio of comonomer units in the PHA block.
References
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Journal ArticleDOI
Biodegradable long-circulating polymeric nanospheres
Ruxandra Gref,Yoshiharu Minamitake,Maria Teresa Peracchia,Vladimir S. Trubetskoy,Vladimir P. Torchilin,Robert Langer +5 more
TL;DR: Monodisperse biodegradable nanospheres were developed from amphiphilic copolymers composed of two biocompatible blocks and exhibited dramatically increased blood circulation times and reduced liver accumulation in mice.
Journal ArticleDOI
Polymeric Systems for Controlled Drug Release
TL;DR: Kevin Shakesheff investigates new methods of engineering polymer surfaces and the application of these engineered materials in drug delivery and tissue engineering.
Journal ArticleDOI
Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers
TL;DR: In this paper, a new approach for the preparation of nanoparticles made solely of hydrophilic polymers is presented, based on an ionic gelation process, is extremely mild and involves the mixture of two aqueous phases at room temperature.
Journal ArticleDOI
Protein—surface interactions in the presence of polyethylene oxide
TL;DR: In this paper, the steric repulsion free energy and van der Waals attraction free energy of polyethylene oxide (PEO) chains were calculated as a function of surface density and chain length of PEO.
Book
Principles of tissue engineering
TL;DR: The history and Scope of Tissue Engineering, J.P. Vavanti and C.A. Vacanti, and Quantitative Aspects of Tissues Engineering: Basic Issues in Kinetics, Transport, and Mechanics are reviewed.
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