Journal ArticleDOI
Biodegradable polymeric nanoparticles as drug delivery devices
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TLDR
This review presents the most outstanding contributions in the field of biodegradable polymeric nanoparticles used as drug delivery systems from 1990 through mid-2000.About:
This article is published in Journal of Controlled Release.The article was published on 2001-01-29. It has received 3284 citations till now. The article focuses on the topics: Drug carrier & Drug delivery.read more
Citations
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Nanotechnology in therapeutics: a focus on nanoparticles as a drug delivery system.
Suwussa Bamrungsap,Zilong Zhao,Zilong Zhao,Tao Chen,Lin Wang,Chun Mei Li,Ting Fu,Weihong Tan +7 more
TL;DR: Recent developments in the use of nanoparticles as drug delivery systems to treat a wide variety of diseases are reviewed and challenges and future nanotechnology strategies to overcome limitations are introduced.
Journal ArticleDOI
Multifunctional Nanoparticles for Drug Delivery and Molecular Imaging
TL;DR: The techniques used in the synthesis of complex nanostructures are summarized, the major forms of multifunctional nanoparticles that have emerged over the past few years are reviewed, and a perceptual vision of this important field of nanomedicine is provided.
Journal ArticleDOI
Delivery of therapeutic proteins.
TL;DR: This review includes a general discussion on covalent attachment of poly(ethylene glycol) (PEG), polysialic acid, or glycolic acid as well as developing new formulations containing nanoparticulate or colloidal systems (e.g., liposomes, polymeric microspheres,polymeric nanoparticles).
Journal ArticleDOI
Drug transport to brain with targeted nanoparticles.
TL;DR: Using peptidomimetic antibodies to BBB transcytosis receptor, brain-targeted pegylated immunonanoparticles can now be synthesized that should make possible the delivery of entrapped actives into the brain parenchyma without inducing BBB permeability alteration.
Journal ArticleDOI
Triggered destabilisation of polymeric micelles and vesicles by changing polymers polarity: an attractive tool for drug delivery.
TL;DR: A variety of mechanisms have recently been described to accomplish the destabilisation of polymeric micelles and vesicles by temperature, pH, chemical or enzymatic hydrolysis of side chains, oxidation/reduction processes, and light.
References
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Journal ArticleDOI
Biodegradable long-circulating polymeric nanospheres
Ruxandra Gref,Yoshiharu Minamitake,Maria Teresa Peracchia,Vladimir S. Trubetskoy,Vladimir P. Torchilin,Robert Langer +5 more
TL;DR: Monodisperse biodegradable nanospheres were developed from amphiphilic copolymers composed of two biocompatible blocks and exhibited dramatically increased blood circulation times and reduced liver accumulation in mice.
Journal ArticleDOI
Polymeric Systems for Controlled Drug Release
TL;DR: Kevin Shakesheff investigates new methods of engineering polymer surfaces and the application of these engineered materials in drug delivery and tissue engineering.
Journal ArticleDOI
Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers
TL;DR: In this paper, a new approach for the preparation of nanoparticles made solely of hydrophilic polymers is presented, based on an ionic gelation process, is extremely mild and involves the mixture of two aqueous phases at room temperature.
Journal ArticleDOI
Protein—surface interactions in the presence of polyethylene oxide
TL;DR: In this paper, the steric repulsion free energy and van der Waals attraction free energy of polyethylene oxide (PEO) chains were calculated as a function of surface density and chain length of PEO.
Book
Principles of tissue engineering
TL;DR: The history and Scope of Tissue Engineering, J.P. Vavanti and C.A. Vacanti, and Quantitative Aspects of Tissues Engineering: Basic Issues in Kinetics, Transport, and Mechanics are reviewed.
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