Candidate Genes Expression Profile Associated with Antidepressants Response in the GENDEP Study: Differentiating between Baseline ‘Predictors' and Longitudinal ‘Targets'
Annamaria Cattaneo,Massimo Gennarelli,Rudolf Uher,Gerome Breen,Anne Farmer,Katherine J. Aitchison,Katherine J. Aitchison,Ian W. Craig,Christoph Anacker,Patricia A Zunsztain,Peter McGuffin,Carmine M. Pariante +11 more
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In this article, the leukocyte mRNA expression levels of genes belonging to glucocorticoid receptor (GR) function (FKBP-4, FKBP-5, and GR), inflammatory cytokines (interleukin (IL)-1a, IL-1b), IL-6 and IL-7), macrophage inhibiting factor (MIF), and tumor necrosis factor (TNF)-a), were tested before and after 8 weeks of treatment with escitalopram or nortriptyline, as part of the Genome-About:
This article is published in Neuropsychopharmacology.The article was published on 2013-02-01 and is currently open access. It has received 342 citations till now. The article focuses on the topics: Proinflammatory cytokine.read more
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Transcriptomics in Interferon-α-Treated Patients Identifies Inflammation-, Neuroplasticity- and Oxidative Stress-Related Signatures as Predictors and Correlates of Depression.
Nilay Hepgul,Annamaria Cattaneo,Annamaria Cattaneo,Kosh Agarwal,Sara Baraldi,Alessandra Borsini,Chiara Bufalino,Daniel M. Forton,Valeria Mondelli,Naghmeh Nikkheslat,Nicola Lopizzo,Marco A. Riva,Alice Russell,Matthew Hotopf,Carmine M. Pariante +14 more
TL;DR: Patients who develop IFN-α-induced depression have an increased biological sensitivity to interferon-α, as shown by larger gene expression changes, and specific signatures both as predictors and as correlates.
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Molecular mechanism of noradrenaline during the stress-induced major depressive disorder.
TL;DR: The role of NA in pathophysiology of stress and the mechanism of therapeutic effect ofNA in MDD is discussed and the possible contributions of each subtype of noradrenergic receptors on LC neurons, hypothalamic-pituitary-adrenal axis (HPA-axis) and brain derived neurotrophic factor-induced hippocampal neurogenesis during stress are discussed.
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Reversal of corticosterone-induced BDNF alterations by the natural antioxidant alpha-lipoic acid alone and combined with desvenlafaxine: Emphasis on the neurotrophic hypothesis of depression
Caren Nádia Soares de Sousa,L.N. Meneses,Germana Silva Vasconcelos,Márcia Calheiros Chaves Silva,Jéssica Calheiros da Silva,Danielle Silveira Macêdo,David Freitas de Lucena,Silvânia Maria Mendes Vasconcelos +7 more
TL;DR: The combination of the DVS and ALA200 reversed CORT-induced alterations in BDNF and even increased the levels of this neurotrophin when compared to vehicle-treated animals in HC and ST.
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Brain-derived neurotrophic factor Val66Met polymorphism association with antidepressant efficacy: a systematic review and meta-analysis.
TL;DR: A systematic review and meta‐analysis of the association of the brain‐derived neurotrophic factor Val66Met polymorphism with antidepressant efficacy in mice found it to be inconsistent.
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Crosstalk between endocannabinoid and immune systems: a potential dysregulation in depression?
TL;DR: The eCB and immune systems have been individually associated with and implicated in pathogenic mechanisms of depression, and a dysregulation in this crosstalk has potential to influence the onset and maintenance of this neuropsychiatric illness.
References
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An inventory for measuring depression
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A new depression scale designed to be sensitive to change.
Stuart Montgomery,Marie Åsberg +1 more
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Development of a Rating Scale for Primary Depressive Illness
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A Meta-Analysis of Cytokines in Major Depression
Yekta Dowlati,Nathan Herrmann,Nathan Herrmann,Walter Swardfager,Walter Swardfager,Helena Liu,Lauren Sham,Elyse K. Reim,Krista L. Lanctôt,Krista L. Lanctôt +9 more
TL;DR: A meta-analysis of studies measuring cytokine concentration in patients with major depression reports significantly higher concentrations of the proinflammatory cytokines TNF-alpha and IL-6 in depressed subjects compared with control subjects, strengthening evidence that depression is accompanied by activation of the IRS.
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The HPA axis in major depression: classical theories and new developments
TL;DR: It is shown that hyperactivity of the hypothalamic-pituitary-adrenal axis is one of the most consistent biological findings in major depression psychiatry, but the mechanisms underlying this abnormality are still unclear.