Candidate Genes Expression Profile Associated with Antidepressants Response in the GENDEP Study: Differentiating between Baseline ‘Predictors' and Longitudinal ‘Targets'
Annamaria Cattaneo,Massimo Gennarelli,Rudolf Uher,Gerome Breen,Anne Farmer,Katherine J. Aitchison,Katherine J. Aitchison,Ian W. Craig,Christoph Anacker,Patricia A Zunsztain,Peter McGuffin,Carmine M. Pariante +11 more
Reads0
Chats0
TLDR
In this article, the leukocyte mRNA expression levels of genes belonging to glucocorticoid receptor (GR) function (FKBP-4, FKBP-5, and GR), inflammatory cytokines (interleukin (IL)-1a, IL-1b), IL-6 and IL-7), macrophage inhibiting factor (MIF), and tumor necrosis factor (TNF)-a), were tested before and after 8 weeks of treatment with escitalopram or nortriptyline, as part of the Genome-About:
This article is published in Neuropsychopharmacology.The article was published on 2013-02-01 and is currently open access. It has received 342 citations till now. The article focuses on the topics: Proinflammatory cytokine.read more
Citations
More filters
Journal ArticleDOI
What does plasma CRP tell us about peripheral and central inflammation in depression
Jennifer C. Felger,Ebrahim Haroon,Trusharth Patel,David R. Goldsmith,Evanthia C. Wommack,Bobbi J. Woolwine,Ngoc-Anh Le,Rachel Feinberg,Malú G. Tansey,Andrew H. Miller +9 more
TL;DR: CRP appears to be a peripheral biomarker that reflects peripheral and central inflammation and seems well-suited for guiding immunotherapies targeting TNF and IL-6 in patients with MDD.
Journal ArticleDOI
Imaging the Role of Inflammation in Mood and Anxiety-related Disorders
TL;DR: Neuroimaging effects of inflammation on reward and threat circuitry may be used as biomarkers of inflammation for future development of novel therapeutic strategies to better treat mood and anxiety-related disorders in patients with high inflammation.
Journal ArticleDOI
Treatment-resistant depression and peripheral C-reactive protein.
Samuel R. Chamberlain,Jonathan Cavanagh,Peter de Boer,Valeria Mondelli,Declan Jones,Wayne C. Drevets,Philip J. Cowen,Neil A. Harrison,Linda Pointon,Carmine M. Pariante,Edward T. Bullmore +10 more
TL;DR: It is suggested that patients with MDD stratified for proinflammatory biomarkers, like CRP, have a distinctive clinical profile that might be responsive to second-line treatment with anti-inflammatory drugs.
Journal ArticleDOI
Cortisol and Inflammatory Biomarkers Predict Poor Treatment Response in First Episode Psychosis
Valeria Mondelli,Valeria Mondelli,Simone Ciufolini,Simone Ciufolini,Martino Belvederi Murri,Stefania Bonaccorso,Marta Di Forti,Annalisa Giordano,Tiago Reis Marques,Patricia A. Zunszain,Patricia A. Zunszain,Craig Morgan,Robin M. Murray,Robin M. Murray,Carmine M. Pariante,Carmine M. Pariante,Paola Dazzan,Paola Dazzan +17 more
TL;DR: Cortisol and inflammatory biomarkers at the onset of psychosis should be considered as possible predictors of treatment response, as well as potential targets for the development of novel therapeutic agents.
Journal ArticleDOI
Flattening the Curve for Incarcerated Populations - Covid-19 in Jails and Prisons.
TL;DR: Flattening the Curve for Incarcerated Populations People caught up in the U.S. justice system have already been affected by SARS-CoV-2, and improved preparation is essential to minimizing the impact of the virus.
References
More filters
Journal ArticleDOI
An inventory for measuring depression
TL;DR: The difficulties inherent in obtaining consistent and adequate diagnoses for the purposes of research and therapy have been pointed out and a wide variety of psychiatric rating scales have been developed.
Journal ArticleDOI
A new depression scale designed to be sensitive to change.
Stuart Montgomery,Marie Åsberg +1 more
TL;DR: The construction of a depression rating scale designed to be particularly sensitive to treatment effects is described, and its capacity to differentiate between responders and non-responders to antidepressant treatment was better than the HRS, indicating greater sensitivity to change.
Journal ArticleDOI
Development of a Rating Scale for Primary Depressive Illness
TL;DR: This is an account of further work on a rating scale for depressive states, including a detailed discussion on the general problems of comparing successive samples from a ‘population’, the meaning of factor scores, and the other results obtained.
Journal ArticleDOI
A Meta-Analysis of Cytokines in Major Depression
Yekta Dowlati,Nathan Herrmann,Nathan Herrmann,Walter Swardfager,Walter Swardfager,Helena Liu,Lauren Sham,Elyse K. Reim,Krista L. Lanctôt,Krista L. Lanctôt +9 more
TL;DR: A meta-analysis of studies measuring cytokine concentration in patients with major depression reports significantly higher concentrations of the proinflammatory cytokines TNF-alpha and IL-6 in depressed subjects compared with control subjects, strengthening evidence that depression is accompanied by activation of the IRS.
Journal ArticleDOI
The HPA axis in major depression: classical theories and new developments
TL;DR: It is shown that hyperactivity of the hypothalamic-pituitary-adrenal axis is one of the most consistent biological findings in major depression psychiatry, but the mechanisms underlying this abnormality are still unclear.