Candidate Genes Expression Profile Associated with Antidepressants Response in the GENDEP Study: Differentiating between Baseline ‘Predictors' and Longitudinal ‘Targets'
Annamaria Cattaneo,Massimo Gennarelli,Rudolf Uher,Gerome Breen,Anne Farmer,Katherine J. Aitchison,Katherine J. Aitchison,Ian W. Craig,Christoph Anacker,Patricia A Zunsztain,Peter McGuffin,Carmine M. Pariante +11 more
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In this article, the leukocyte mRNA expression levels of genes belonging to glucocorticoid receptor (GR) function (FKBP-4, FKBP-5, and GR), inflammatory cytokines (interleukin (IL)-1a, IL-1b), IL-6 and IL-7), macrophage inhibiting factor (MIF), and tumor necrosis factor (TNF)-a), were tested before and after 8 weeks of treatment with escitalopram or nortriptyline, as part of the Genome-About:
This article is published in Neuropsychopharmacology.The article was published on 2013-02-01 and is currently open access. It has received 342 citations till now. The article focuses on the topics: Proinflammatory cytokine.read more
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Pro-inflammatory Cytokines, Biomarkers, Genetics and the Immune System: A Mechanistic Approach of Depression and Psoriasis
Daniyal Aleem,Hassaan Tohid +1 more
TL;DR: A possible bidirectional relationship of psoriasis and major depression exists; i.e. the depression leads to Psoriasis, andPsoriasis leads to depression.
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Disease- and treatment-associated acquired glucocorticoid resistance
TL;DR: It is argued that future strategies to prevent GC resistance should involve biased ligands with a predisposition for reduced GR dimerization, a strategy originally proposed as the SEMOGRAM–SEDIGRAM concept to reduce the side-effect profile of GCs.
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RNA expression profiling in depressed patients suggests retinoid-related orphan receptor alpha as a biomarker for antidepressant response
Johannes M. Hennings,Manfred Uhr,Torsten Klengel,Patrick Weber,Benno Pütz,Chadi Touma,Darina Czamara,Marcus Ising,F. Holsboer,Susanne Lucae +9 more
TL;DR: Using a genome-wide transcriptomics approach and subsequent validation studies, several transcripts including the circadian gene transcript RORa that may serve as biomarkers indicating antidepressant treatment response are identified.
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Dysregulation of leukocyte gene expression in women with medication-refractory depression versus healthy non-depressed controls
Eli Iacob,Kathleen C. Light,Scott C Tadler,Howard Weeks,Andrea T. White,Ronald W. Hughen,Timothy A. VanHaitsma,Lowry Bushnell,Alan R. Light +8 more
TL;DR: These results support prior findings of dysregulation in immune genes, and provide preliminary evidence of Dysregulation in purinergic and other ion channels in females with medication-refractory depression, and in transcription and growth factors in those with BPD.
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Nutrition, psychoneuroimmunology and depression: the therapeutic implications of omega-3 fatty acids in interferon-α-induced depression
TL;DR: Recent epidemiological studies, cross-sectional and longitudinal case-controlled studies, interventional clinical trials, as well as basic animal and cellular studies are reviewed to prove the linkage among omega-3 PUFAs, inflammation, and depression.
References
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Yekta Dowlati,Nathan Herrmann,Nathan Herrmann,Walter Swardfager,Walter Swardfager,Helena Liu,Lauren Sham,Elyse K. Reim,Krista L. Lanctôt,Krista L. Lanctôt +9 more
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The HPA axis in major depression: classical theories and new developments
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