Candidate Genes Expression Profile Associated with Antidepressants Response in the GENDEP Study: Differentiating between Baseline ‘Predictors' and Longitudinal ‘Targets'
Annamaria Cattaneo,Massimo Gennarelli,Rudolf Uher,Gerome Breen,Anne Farmer,Katherine J. Aitchison,Katherine J. Aitchison,Ian W. Craig,Christoph Anacker,Patricia A Zunsztain,Peter McGuffin,Carmine M. Pariante +11 more
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In this article, the leukocyte mRNA expression levels of genes belonging to glucocorticoid receptor (GR) function (FKBP-4, FKBP-5, and GR), inflammatory cytokines (interleukin (IL)-1a, IL-1b), IL-6 and IL-7), macrophage inhibiting factor (MIF), and tumor necrosis factor (TNF)-a), were tested before and after 8 weeks of treatment with escitalopram or nortriptyline, as part of the Genome-About:
This article is published in Neuropsychopharmacology.The article was published on 2013-02-01 and is currently open access. It has received 342 citations till now. The article focuses on the topics: Proinflammatory cytokine.read more
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Depression and inflammation: Correlation between changes in inflammatory markers with antidepressant response and long-term prognosis
TL;DR: In this paper , the authors performed secondary analyses among 90 outpatients with moderate-severe depression (71% female, mean age 38 years) treated for 26 weeks with escitalopram or nortriptyline and measured 27 pro-and anti-inflammatory markers at week 0, 8, 12, and 26 and calculated composite inflammation scores.
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The Role of Peripheral Inflammation in Clinical Outcome and Brain Imaging Abnormalities in Psychosis: A Systematic Review.
Melisa Kose,Carmine M. Pariante,Carmine M. Pariante,Paola Dazzan,Paola Dazzan,Valeria Mondelli,Valeria Mondelli +6 more
TL;DR: In this paper, a systematic review aims to clarify the potential role of peripheral inflammatory markers as predictors of clinical outcomes and their association with neuroimaging markers in patients with psychosis.
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Neuropsin Inactivation Has Protective Effects against Depressive-Like Behaviours and Memory Impairment Induced by Chronic Stress
TL;DR: It is demonstrated that neuropsin inactivation protects against the impairment of hippocampal functions and the depressive-like behaviour induced by chronic stress or high levels of corticosterone, and is a potential target for clinical interventions for the management of stress disorders.
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VGF has Roles in the Pathogenesis of Major Depressive Disorder and Schizophrenia: Evidence from Transgenic Mouse Models.
TL;DR: Studies of the roles of VGF using transgenic mice and its relevance to pathologies in major depressive disorder and schizophrenia are discussed.
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SLC6A2 variants may predict remission from major depression after venlafaxine treatment in Han Chinese population
Yi Wei Yeh,Cheng Jueng Chen,Fong Lin Jang,Shin Chang Kuo,Chun-Yen Chen,Chih-Sung Liang,Pei Shen Ho,Che Hung Yen,Jia Fwu Shyu,Fang Jung Wan,Ru Band Lu,San Yuan Huang +11 more
TL;DR: The results suggest that the variation of the SLC6A2 gene is associated with treatment remission after venlafaxine in patients with MDD.
References
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Development of a Rating Scale for Primary Depressive Illness
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A Meta-Analysis of Cytokines in Major Depression
Yekta Dowlati,Nathan Herrmann,Nathan Herrmann,Walter Swardfager,Walter Swardfager,Helena Liu,Lauren Sham,Elyse K. Reim,Krista L. Lanctôt,Krista L. Lanctôt +9 more
TL;DR: A meta-analysis of studies measuring cytokine concentration in patients with major depression reports significantly higher concentrations of the proinflammatory cytokines TNF-alpha and IL-6 in depressed subjects compared with control subjects, strengthening evidence that depression is accompanied by activation of the IRS.
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The HPA axis in major depression: classical theories and new developments
TL;DR: It is shown that hyperactivity of the hypothalamic-pituitary-adrenal axis is one of the most consistent biological findings in major depression psychiatry, but the mechanisms underlying this abnormality are still unclear.