Candidate Genes Expression Profile Associated with Antidepressants Response in the GENDEP Study: Differentiating between Baseline ‘Predictors' and Longitudinal ‘Targets'
Annamaria Cattaneo,Massimo Gennarelli,Rudolf Uher,Gerome Breen,Anne Farmer,Katherine J. Aitchison,Katherine J. Aitchison,Ian W. Craig,Christoph Anacker,Patricia A Zunsztain,Peter McGuffin,Carmine M. Pariante +11 more
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TLDR
In this article, the leukocyte mRNA expression levels of genes belonging to glucocorticoid receptor (GR) function (FKBP-4, FKBP-5, and GR), inflammatory cytokines (interleukin (IL)-1a, IL-1b), IL-6 and IL-7), macrophage inhibiting factor (MIF), and tumor necrosis factor (TNF)-a), were tested before and after 8 weeks of treatment with escitalopram or nortriptyline, as part of the Genome-About:
This article is published in Neuropsychopharmacology.The article was published on 2013-02-01 and is currently open access. It has received 342 citations till now. The article focuses on the topics: Proinflammatory cytokine.read more
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Tumor necrosis factor and its targets in the inflammatory cytokine pathway are identified as putative transcriptomic biomarkers for escitalopram response.
Timothy R. Powell,Leonard C. Schalkwyk,Andrew L Heffernan,Gerome Breen,Timothy Lawrence,Thomas S. Price,Anne Farmer,Katherine J. Aitchison,Katherine J. Aitchison,Ian W. Craig,Andrea Danese,Catherine Lewis,Peter McGuffin,Rudolf Uher,Rudolf Uher,Katherine E. Tansey,Ursula M. D'Souza +16 more
TL;DR: Substantial support is added for the role of the inflammatory cytokine pathway in mediating response to the SSRI escitalopram, and the first to identify TNF and its targets as putative transcriptomic predictors of clinical response.
Journal ArticleDOI
Immune and neurotrophin stimulation by electroconvulsive therapy: is some inflammation needed after all?
E. M. van Buel,Kostas Patas,Kostas Patas,M Peters,Fokko J. Bosker,Ulrich L. M. Eisel,Hans C. Klein +6 more
TL;DR: It is concluded that targeted potentiation, rather than suppression, of inflammatory responses may be of therapeutic relevance to chronically depressed patients or a subgroup thereof.
Journal ArticleDOI
Association between serum brain-derived neurotrophic factor and plasma interleukin-6 in major depressive disorder with melancholic features
Konstantinos Patas,Konstantinos Patas,Brenda W.J.H. Penninx,Boudewijn A.A. Bus,Nicole Vogelzangs,Marc L. Molendijk,Bernet M. Elzinga,Fokko J. Bosker,Richard C. Oude Voshaar +8 more
TL;DR: An allostatic, BDNF-inducing component of peripheral immunity and/or an immunotrophic function of peripheral BDNF are disclosed, as they could inform new research concepts towards immune-based antidepressive treatment strategies.
Journal ArticleDOI
Inflammation and decreased functional connectivity in a widely-distributed network in depression: Centralized effects in the ventral medial prefrontal cortex.
Lijun Yin,Xiaodan Xu,Gang Chen,Neeti D. Mehta,Ebrahim Haroon,Andrew H. Miller,Yuejia Luo,Zhihao Li,Zhihao Li,Jennifer C. Felger +9 more
TL;DR: A large-scale network-based analyses of resting-state functional magnetic resonance imaging data acquired from depressed patients with varying levels of inflammation provided further support for inflammation as a distinct contributing factor to network dysfunction and symptom severity in depression.
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The effects of interleukin-6 neutralizing antibodies on symptoms of depressed mood and anhedonia in patients with rheumatoid arthritis and multicentric Castleman’s disease
Yu Sun,D. Wang,Giacomo Salvadore,Benjamin Hsu,Mark E. Curran,Corey Casper,Jessica Vermeulen,Justine M. Kent,Jaskaran Singh,Wayne C. Drevets,Gayle M. Wittenberg,Guang Chen +11 more
TL;DR: The data together suggest that the IL-6 antibodies improve depressive symptoms in patients with rheumatoid arthritis and MCD through improving primary disease dependent and independent mechanisms and the brain mechanisms underlying depressive symptom improvements.
References
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