Candidate Genes Expression Profile Associated with Antidepressants Response in the GENDEP Study: Differentiating between Baseline ‘Predictors' and Longitudinal ‘Targets'
Annamaria Cattaneo,Massimo Gennarelli,Rudolf Uher,Gerome Breen,Anne Farmer,Katherine J. Aitchison,Katherine J. Aitchison,Ian W. Craig,Christoph Anacker,Patricia A Zunsztain,Peter McGuffin,Carmine M. Pariante +11 more
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In this article, the leukocyte mRNA expression levels of genes belonging to glucocorticoid receptor (GR) function (FKBP-4, FKBP-5, and GR), inflammatory cytokines (interleukin (IL)-1a, IL-1b), IL-6 and IL-7), macrophage inhibiting factor (MIF), and tumor necrosis factor (TNF)-a), were tested before and after 8 weeks of treatment with escitalopram or nortriptyline, as part of the Genome-About:
This article is published in Neuropsychopharmacology.The article was published on 2013-02-01 and is currently open access. It has received 342 citations till now. The article focuses on the topics: Proinflammatory cytokine.read more
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Blood-based biomarkers predicting response to antidepressants.
Yasmin Busch,Andreas Menke +1 more
TL;DR: There is still a great need for studies investigating and validating biomarkers for the prediction of treatment response to facilitate the treatment selection and shorten the time to remission and thus provide personalized medicine in psychiatry.
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Towards a personalized treatment in depression: endocannabinoids, inflammation and stress response.
TL;DR: The crosstalk between the endocannabinoid system, immune system and HPA axis is reviewed; the evidence of gene polymorphisms and their relation to the risk of depression and its treatment is discussed; and future directions where genes of these three systems are considered from a joint perspective to improve prediction of treatment response are proposed.
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Elevated plasma macrophage migration inhibitor factor as a risk factor for the development of post-stroke depression in ischemic stroke.
TL;DR: It is demonstrated that elevated plasma levels of MIF at admission were associated with increased risk of PSD in the next three months and might be useful in identifying stroke at risk for PSD for early prevention strategies.
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Mitochondria: A Connecting Link In The Major Depressive Disorder Jigsaw
TL;DR: Mitochondria are integral to the function of neurons and undergo dysfunction in major depressive disorder patients and are reflected in all the various hypotheses that have been proposed for depression, including the role of exogenous ATP.
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Gene expression in blood of children and adolescents: Mediation between childhood maltreatment and major depressive disorder.
Leticia Spindola,Pedro Mario Pan,Patricia Moretti,Vanessa Kiyomi Ota,Marcos L. Santoro,Hugo Cogo-Moreira,Ary Gadelha,Giovanni Abrahão Salum,Gisele Gus Manfro,Jair de Jesus Mari,Helena Brentani,Rodrigo Grassi-Oliveira,Elisa Brietzke,Euripedes Constantino Miguel,Luis Augusto Rohde,João Ricardo Sato,Rodrigo A. Bressan,Sintia Iole Belangero +17 more
TL;DR: It is demonstrated that NR3C1, TNF, TNFR1 and IL1B expression levels are related to MDD and conjunctly mediate the effect of CM history on the risk of developing MDD, which supports a role of glucocorticoids and inflammation as potential effectors of environmental stress in MDD.
References
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An inventory for measuring depression
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A new depression scale designed to be sensitive to change.
Stuart Montgomery,Marie Åsberg +1 more
TL;DR: The construction of a depression rating scale designed to be particularly sensitive to treatment effects is described, and its capacity to differentiate between responders and non-responders to antidepressant treatment was better than the HRS, indicating greater sensitivity to change.
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Development of a Rating Scale for Primary Depressive Illness
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A Meta-Analysis of Cytokines in Major Depression
Yekta Dowlati,Nathan Herrmann,Nathan Herrmann,Walter Swardfager,Walter Swardfager,Helena Liu,Lauren Sham,Elyse K. Reim,Krista L. Lanctôt,Krista L. Lanctôt +9 more
TL;DR: A meta-analysis of studies measuring cytokine concentration in patients with major depression reports significantly higher concentrations of the proinflammatory cytokines TNF-alpha and IL-6 in depressed subjects compared with control subjects, strengthening evidence that depression is accompanied by activation of the IRS.
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The HPA axis in major depression: classical theories and new developments
TL;DR: It is shown that hyperactivity of the hypothalamic-pituitary-adrenal axis is one of the most consistent biological findings in major depression psychiatry, but the mechanisms underlying this abnormality are still unclear.