Candidate Genes Expression Profile Associated with Antidepressants Response in the GENDEP Study: Differentiating between Baseline ‘Predictors' and Longitudinal ‘Targets'
Annamaria Cattaneo,Massimo Gennarelli,Rudolf Uher,Gerome Breen,Anne Farmer,Katherine J. Aitchison,Katherine J. Aitchison,Ian W. Craig,Christoph Anacker,Patricia A Zunsztain,Peter McGuffin,Carmine M. Pariante +11 more
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In this article, the leukocyte mRNA expression levels of genes belonging to glucocorticoid receptor (GR) function (FKBP-4, FKBP-5, and GR), inflammatory cytokines (interleukin (IL)-1a, IL-1b), IL-6 and IL-7), macrophage inhibiting factor (MIF), and tumor necrosis factor (TNF)-a), were tested before and after 8 weeks of treatment with escitalopram or nortriptyline, as part of the Genome-About:
This article is published in Neuropsychopharmacology.The article was published on 2013-02-01 and is currently open access. It has received 342 citations till now. The article focuses on the topics: Proinflammatory cytokine.read more
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Gene expression in major depressive disorder
Rick Jansen,Brenda W.J.H. Penninx,Vered Madar,Kai Xia,Y. Milaneschi,Jouke-Jan Hottenga,Anke R. Hammerschlag,A.T.F. Beekman,N van der Wee,Jan Smit,Andrew Brooks,Jay A. Tischfield,Danielle Posthuma,Robert A. Schoevers,G van Grootheest,Gonneke Willemsen,E.J.C. de Geus,Dorret I. Boomsma,Fred A. Wright,Fred A. Wright,Fei Zou,Wei Sun,Patrick F. Sullivan +22 more
TL;DR: Multiple gene expression associations with MDD were identified and a measurable impact of current MDD state on gene expression is suggested, in line with the immune suppression and immune activation hypothesis of MDD.
Journal ArticleDOI
Integrating Interleukin-6 into depression diagnosis and treatment
TL;DR: By examining the contribution of both peripheral and central IL-6 to manifestations of stress-related symptomatology, this work hopes to broaden the way the field thinks about diagnosing and treating mood disorders.
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Depression Heterogeneity and Its Biological Underpinnings: Toward Immunometabolic Depression
TL;DR: It is illustrated that such biological dysregulations map more consistently to atypical behavioral symptoms reflecting altered energy intake/expenditure balance and may moderate the antidepressant effects of standard or novel therapeutic approaches.
Journal ArticleDOI
The human BDNF gene: peripheral gene expression and protein levels as biomarkers for psychiatric disorders.
TL;DR: A description of the human BDNF gene structure is provided as well as a summary of clinical and preclinical evidence supporting the role of BDNF in the pathogenesis of psychiatric disorders and the potential use of peripheral BDNF as a biomarker for psychiatric disorders.
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Omega-3 Fatty Acids in the Prevention of Interferon-Alpha-Induced Depression: Results from a Randomized, Controlled Trial
Kuan-Pin Su,Kuan-Pin Su,Kuan-Pin Su,Hsueh Chou Lai,Hui Ting Yang,Wen-Pang Su,Cheng Yuan Peng,Jane Pei-Chen Chang,Hui Chih Chang,Hui Chih Chang,Hui Chih Chang,Carmine M. Pariante +11 more
TL;DR: EPA is effective in the prevention of depression in hepatitis C virus patients received IFN-α therapy, confirming the notion that anti-inflammatory strategies are effective antidepressants in the context of depression associated with inflammation.
References
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An inventory for measuring depression
TL;DR: The difficulties inherent in obtaining consistent and adequate diagnoses for the purposes of research and therapy have been pointed out and a wide variety of psychiatric rating scales have been developed.
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A new depression scale designed to be sensitive to change.
Stuart Montgomery,Marie Åsberg +1 more
TL;DR: The construction of a depression rating scale designed to be particularly sensitive to treatment effects is described, and its capacity to differentiate between responders and non-responders to antidepressant treatment was better than the HRS, indicating greater sensitivity to change.
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Development of a Rating Scale for Primary Depressive Illness
TL;DR: This is an account of further work on a rating scale for depressive states, including a detailed discussion on the general problems of comparing successive samples from a ‘population’, the meaning of factor scores, and the other results obtained.
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A Meta-Analysis of Cytokines in Major Depression
Yekta Dowlati,Nathan Herrmann,Nathan Herrmann,Walter Swardfager,Walter Swardfager,Helena Liu,Lauren Sham,Elyse K. Reim,Krista L. Lanctôt,Krista L. Lanctôt +9 more
TL;DR: A meta-analysis of studies measuring cytokine concentration in patients with major depression reports significantly higher concentrations of the proinflammatory cytokines TNF-alpha and IL-6 in depressed subjects compared with control subjects, strengthening evidence that depression is accompanied by activation of the IRS.
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The HPA axis in major depression: classical theories and new developments
TL;DR: It is shown that hyperactivity of the hypothalamic-pituitary-adrenal axis is one of the most consistent biological findings in major depression psychiatry, but the mechanisms underlying this abnormality are still unclear.