Candidate Genes Expression Profile Associated with Antidepressants Response in the GENDEP Study: Differentiating between Baseline ‘Predictors' and Longitudinal ‘Targets'
Annamaria Cattaneo,Massimo Gennarelli,Rudolf Uher,Gerome Breen,Anne Farmer,Katherine J. Aitchison,Katherine J. Aitchison,Ian W. Craig,Christoph Anacker,Patricia A Zunsztain,Peter McGuffin,Carmine M. Pariante +11 more
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In this article, the leukocyte mRNA expression levels of genes belonging to glucocorticoid receptor (GR) function (FKBP-4, FKBP-5, and GR), inflammatory cytokines (interleukin (IL)-1a, IL-1b), IL-6 and IL-7), macrophage inhibiting factor (MIF), and tumor necrosis factor (TNF)-a), were tested before and after 8 weeks of treatment with escitalopram or nortriptyline, as part of the Genome-About:
This article is published in Neuropsychopharmacology.The article was published on 2013-02-01 and is currently open access. It has received 342 citations till now. The article focuses on the topics: Proinflammatory cytokine.read more
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Brain-derived neurotrophic factor and inflammation in depression: Pathogenic partners in crime?
TL;DR: This work reviews two prominent risk factors for depression with a particular focus on pathogenic implications of their interaction and suggests that there is bidirectional regulation between these factors with important implications for the development of depressive symptoms and anti-depressant response.
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Dysregulation of the gut-brain-skin axis and key overlapping inflammatory and immune mechanisms of psoriasis and depression.
Xiaoxu Wang,Yafan Li,Yafan Li,Lingjun Wu,Shiju Xiao,Yunrun Ji,Yong Tan,Chunyan Jiang,Guangzhong Zhang +8 more
TL;DR: In this paper, the authors systematically summarized and comparatively analysed the inflammatory and immune mechanisms of psoriasis and depression and illustrated the dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and the gut microbiota.
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Large normal-range TBP and ATXN7 CAG repeat lengths are associated with increased lifetime risk of depression.
Sarah L. Gardiner,M. J. van Belzen,Merel W. Boogaard,W M C van Roon-Mom,Maarten Pieter Rozing,A.M. van Hemert,Jan H. Smit,Aartjan T.F. Beekman,G van Grootheest,Robert A. Schoevers,R.C. Oude Voshaar,Hannie C. Comijs,Brenda W.J.H. Penninx,R.C. van der Mast,R.C. van der Mast,R A C Roos,N A Aziz +16 more
TL;DR: These findings provide critical evidence for the notion that repeat polymorphisms can act as complex genetic modifiers of depression.
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Accumulation of Cytoplasmic Glucocorticoid Receptor Is Related to Elevation of FKBP5 in Lymphocytes of Depressed Patients
Iva Lukic,Milos Mitic,Ivan Soldatovic,Milica Jovicic,Nadja P. Maric,Jelena Radulovic,Miroslav Adzic +6 more
TL;DR: The results suggest that accumulation of the GR in cytoplasm is related to the elevation of FKBP5, adding one more step in understanding altered GR signalling in lymphocytes, and potentially brain tissue, of MDD patients.
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Interoceptive pathways to understand and treat mental health conditions
TL;DR: In this paper , the authors focus on interoceptive pathways of existing and putative mental health treatments, and present a review focusing on the nature of interoception disturbances in mental health conditions, including anxiety, depression, and psychosis.
References
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An inventory for measuring depression
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A new depression scale designed to be sensitive to change.
Stuart Montgomery,Marie Åsberg +1 more
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Development of a Rating Scale for Primary Depressive Illness
TL;DR: This is an account of further work on a rating scale for depressive states, including a detailed discussion on the general problems of comparing successive samples from a ‘population’, the meaning of factor scores, and the other results obtained.
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A Meta-Analysis of Cytokines in Major Depression
Yekta Dowlati,Nathan Herrmann,Nathan Herrmann,Walter Swardfager,Walter Swardfager,Helena Liu,Lauren Sham,Elyse K. Reim,Krista L. Lanctôt,Krista L. Lanctôt +9 more
TL;DR: A meta-analysis of studies measuring cytokine concentration in patients with major depression reports significantly higher concentrations of the proinflammatory cytokines TNF-alpha and IL-6 in depressed subjects compared with control subjects, strengthening evidence that depression is accompanied by activation of the IRS.
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The HPA axis in major depression: classical theories and new developments
TL;DR: It is shown that hyperactivity of the hypothalamic-pituitary-adrenal axis is one of the most consistent biological findings in major depression psychiatry, but the mechanisms underlying this abnormality are still unclear.