Candidate Genes Expression Profile Associated with Antidepressants Response in the GENDEP Study: Differentiating between Baseline ‘Predictors' and Longitudinal ‘Targets'
Annamaria Cattaneo,Massimo Gennarelli,Rudolf Uher,Gerome Breen,Anne Farmer,Katherine J. Aitchison,Katherine J. Aitchison,Ian W. Craig,Christoph Anacker,Patricia A Zunsztain,Peter McGuffin,Carmine M. Pariante +11 more
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TLDR
In this article, the leukocyte mRNA expression levels of genes belonging to glucocorticoid receptor (GR) function (FKBP-4, FKBP-5, and GR), inflammatory cytokines (interleukin (IL)-1a, IL-1b), IL-6 and IL-7), macrophage inhibiting factor (MIF), and tumor necrosis factor (TNF)-a), were tested before and after 8 weeks of treatment with escitalopram or nortriptyline, as part of the Genome-About:
This article is published in Neuropsychopharmacology.The article was published on 2013-02-01 and is currently open access. It has received 342 citations till now. The article focuses on the topics: Proinflammatory cytokine.read more
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The role of inflammation in depression: from evolutionary imperative to modern treatment target
TL;DR: Current understanding of the mechanisms by which the innate and adaptive immune systems interact with neurotransmitters and neurocircuits to influence the risk for depression are detailed.
Journal ArticleDOI
So depression is an inflammatory disease, but where does the inflammation come from?
Michael Berk,Lana J. Williams,Lana J. Williams,Felice N. Jacka,Felice N. Jacka,Adrienne O'Neil,Adrienne O'Neil,Julie A. Pasco,Julie A. Pasco,Steven Moylan,Nicholas B. Allen,Amanda L Stuart,Amie C. Hayley,Michelle L. Byrne,Michael Maes,Michael Maes +15 more
TL;DR: The identification of known sources of inflammation provides support for inflammation as a mediating pathway to both risk and neuroprogression in depression.
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Inflammatory cytokines in depression: Neurobiological mechanisms and therapeutic implications
TL;DR: This review explores the idea that specific gene polymorphisms and neurotransmitter systems can confer protection from or vulnerability to specific symptom dimensions of cytokine-related depression and potential therapeutic strategies that target inflammatory cytokine signaling.
Journal ArticleDOI
Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly
Annamaria Cattaneo,Nadia Cattane,Samantha Galluzzi,Stefania Provasi,Nicola Lopizzo,Cristina Festari,Clarissa Ferrari,Ugo Paolo Guerra,Barbara Paghera,Cristina Muscio,Angelo Bianchetti,Giorgio Dalla Volta,Marinella Turla,Maria Cotelli,Michele Gennuso,Alessandro Prelle,Orazio Zanetti,Giulia Lussignoli,Dario Mirabile,Daniele Bellandi,Simona Gentile,Gloria Belotti,Daniele Villani,Taoufiq Harach,Tristan Bolmont,Alessandro Padovani,Marina Boccardi,Giovanni B. Frisoni +27 more
TL;DR: The data indicate that an increase in the abundance of a pro-inflammatory GMB taxon, Escherichia/Shigella, and a reduction in the abundances of an anti-inflammatoryTaxon, E. rectale, are possibly associated with a peripheral inflammatory state in patients with cognitive impairment and brain amyloidosis.
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Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder
Rita Haapakoski,Rita Haapakoski,Rita Haapakoski,Julia Mathieu,Klaus P. Ebmeier,Harri Alenius,Mika Kivimäki +6 more
TL;DR: This meta-analysis confirms a robust link between IL-6, CRP and major depression and the role of TNF-α and IL-1β in major depression remains uncertain.
References
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Journal ArticleDOI
Glucocorticoid sensitivity in mood disorders.
A.T. Spijker,E.F.C. van Rossum +1 more
TL;DR: The main findings in mood disorders are higher mean cortisol levels in hair samples and a higher CAR, showing a hyperactivity of the HPA axis.
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Characterization and functional significance of glucocorticoid receptors in patients with major depression: modulation by antidepressant treatment
Gaston Diego Calfa,Silvia Kademian,Danilo Guillermo Ceschin,G. Vega,Gabriel A. Rabinovich,Marta Volosin +5 more
TL;DR: Assessment of GR density of peripheral blood mononuclear cells in a group of patients with major depression and modulation of these GR sites by antidepressant treatment suggests a lack of relationship between GR density and cortisol-induced inhibition of lymphocyte proliferation.
Journal ArticleDOI
Altered glucocorticoid immunoregulation in treatment resistant depression
Moisés Evandro Bauer,Andrew Papadopoulos,Lucia Poon,Paula Perks,Stafford L. Lightman,Stuart A. Checkley,Nola Shanks +6 more
TL;DR: The data indicate that alterations in immune function and steroid regulation associated with depression are not related to elevated basal levels of cortisol and suggest that lymphocyte steroid resistance may be associated with TRP.
Journal ArticleDOI
Reduced peripheral brain-derived neurotrophic factor mRNA levels are normalized by antidepressant treatment.
Annamaria Cattaneo,Luisella Bocchio-Chiavetto,Roberta Zanardini,Elena Milanesi,Anna Placentino,Massimo Gennarelli +5 more
TL;DR: The results indicate that BDNF serum modulation observed in depressed patients is associated with BDNF synthesis alteration in leukocytes and suggest that these peripheral cells might play an active role in the mechanisms of action of antidepressants.
Journal ArticleDOI
Preventing relapse and recurrence of depression: a brief review of therapeutic options.
TL;DR: Clinicians should ensure that the patient has been adherent to therapy as prescribed and consider other explanations before attributing relapse or recurrence to diminished responsiveness to antidepressant medication at the neurochemical level.