Candidate Genes Expression Profile Associated with Antidepressants Response in the GENDEP Study: Differentiating between Baseline ‘Predictors' and Longitudinal ‘Targets'
Annamaria Cattaneo,Massimo Gennarelli,Rudolf Uher,Gerome Breen,Anne Farmer,Katherine J. Aitchison,Katherine J. Aitchison,Ian W. Craig,Christoph Anacker,Patricia A Zunsztain,Peter McGuffin,Carmine M. Pariante +11 more
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In this article, the leukocyte mRNA expression levels of genes belonging to glucocorticoid receptor (GR) function (FKBP-4, FKBP-5, and GR), inflammatory cytokines (interleukin (IL)-1a, IL-1b), IL-6 and IL-7), macrophage inhibiting factor (MIF), and tumor necrosis factor (TNF)-a), were tested before and after 8 weeks of treatment with escitalopram or nortriptyline, as part of the Genome-About:
This article is published in Neuropsychopharmacology.The article was published on 2013-02-01 and is currently open access. It has received 342 citations till now. The article focuses on the topics: Proinflammatory cytokine.read more
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Book ChapterDOI
Increased Inflammation and Treatment of Depression: From Resistance to Reuse, Repurposing, and Redesign.
Journal ArticleDOI
Macrophage Migration Inhibitory Factor in Major Depressive Disorder: A Multilevel Pilot Study
C.R. Swoboda,Lena Deloch,Claudia von Zimmermann,Tanja Richter-Schmidinger,Bernd Lenz,Johannes Kornhuber,Christiane Mühle +6 more
TL;DR: In this paper , the potential of MIF at the genetic, expression and protein levels as a risk factor and biomarker to diagnose, monitor, or predict the course of major depressive disorder (MDD) was examined.
Journal ArticleDOI
Macrophage Migration Inhibitory Factor as a Predictor for Long-term Improvements After Mindfulness-Based Group Therapy or Treatment as Usual for Depression, Anxiety or Stress and Adjustment Disorders
Kristina Sundquist,Kristina Sundquist,Karolina Palmér,Ashfaque A. Memon,Jan Sundquist,Jan Sundquist,Xiao Wang +6 more
TL;DR: Higher MIF levels at baseline were significantly associated with better long-term improvement in psychiatric symptoms, as measured by changes in the Montgomery-Åsberg Depression Rating Scale (MADRS-S), and may serve as a potential biomarker that can guide treatment selection for the personalized treatment for patients with psychiatric disorders.
Journal ArticleDOI
Depression and macrophages: A bibliometric and visual analysis from 2000 to 2022
TL;DR: A literature scan covering the period 2000 to 2022 was performed on macrophages in depression, which were analyzed with Citespace 6.1.1 and VOSviewer 1.6.18 after manual screening, including country publications, institutions, authors, journals, keywords, and references as mentioned in this paper .
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The HPA axis in major depression: classical theories and new developments
TL;DR: It is shown that hyperactivity of the hypothalamic-pituitary-adrenal axis is one of the most consistent biological findings in major depression psychiatry, but the mechanisms underlying this abnormality are still unclear.