Candidate Genes Expression Profile Associated with Antidepressants Response in the GENDEP Study: Differentiating between Baseline ‘Predictors' and Longitudinal ‘Targets'
Annamaria Cattaneo,Massimo Gennarelli,Rudolf Uher,Gerome Breen,Anne Farmer,Katherine J. Aitchison,Katherine J. Aitchison,Ian W. Craig,Christoph Anacker,Patricia A Zunsztain,Peter McGuffin,Carmine M. Pariante +11 more
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In this article, the leukocyte mRNA expression levels of genes belonging to glucocorticoid receptor (GR) function (FKBP-4, FKBP-5, and GR), inflammatory cytokines (interleukin (IL)-1a, IL-1b), IL-6 and IL-7), macrophage inhibiting factor (MIF), and tumor necrosis factor (TNF)-a), were tested before and after 8 weeks of treatment with escitalopram or nortriptyline, as part of the Genome-About:
This article is published in Neuropsychopharmacology.The article was published on 2013-02-01 and is currently open access. It has received 342 citations till now. The article focuses on the topics: Proinflammatory cytokine.read more
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Does Diet Matter? The Use of Polyunsaturated Fatty Acids (PUFAs) and Other Dietary Supplements in Inflammation-Associated Depression
TL;DR: This review will examine an emerging area in psychiatry, that of dietary supplements and the diet in general to treat depressive symptoms, and inflammation in depression, and polyunsaturated fatty acids, probiotics and folic acid are three supplements that demonstrate the ability to target inflammation and other underlying systems in depression.
Journal ArticleDOI
Transcriptomic signatures of psychomotor slowing in peripheral blood of depressed patients: evidence for immunometabolic reprogramming.
Mandakh Bekhbat,David R. Goldsmith,Bobbi J. Woolwine,Ebrahim Haroon,Andrew H. Miller,Jennifer C. Felger +5 more
TL;DR: In this article, microarray data were analyzed in a primary cohort of 88 medically-stable, unmedicated, ambulatory major depression patients and two differential co-expression modules enriched for oxidative stress and mitochondrial degradation were associated with improvements in psychomotor reaction time (p < 0.05).
Journal ArticleDOI
Canonical TGF-β signaling regulates the relationship between prenatal maternal depression and amygdala development in early life.
Anqi Qiu,Han Zhang,Changqing Wang,Yap Seng Chong,Lynette Pei-Chi Shek,Peter D. Gluckman,Michael J. Meaney,Marielle V. Fortier,Yonghui Wu +8 more
TL;DR: In this article, the authors examined the role of the canonical transforming growth factor-beta (TGF-β) signaling in linking prenatal maternal depressive symptoms and the amygdala volumes from birth to 6 years of age.
Journal ArticleDOI
Sex hormones and immune system: A possible interplay in affective disorders? A systematic review.
TL;DR: In this article, a systematic review of the evidence supporting a possible association between sex hormones and inflammatory biomarkers in people with affective disorders is presented, which highlights the need to investigate the interplay between sex hormone and immune system in affective disorder.
Journal ArticleDOI
Neuroinflammation as a Common Denominator of Complex Diseases (Cancer, Diabetes Type 2, and Neuropsychiatric Disorders).
TL;DR: The role played by neuroinflammation has been acknowledged in different disease entities as mentioned in this paper, including cancer, type 2 diabetes (T2DM), and neuropsychiatric disorders (focusing on mood disorders).
References
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An inventory for measuring depression
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A new depression scale designed to be sensitive to change.
Stuart Montgomery,Marie Åsberg +1 more
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Development of a Rating Scale for Primary Depressive Illness
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A Meta-Analysis of Cytokines in Major Depression
Yekta Dowlati,Nathan Herrmann,Nathan Herrmann,Walter Swardfager,Walter Swardfager,Helena Liu,Lauren Sham,Elyse K. Reim,Krista L. Lanctôt,Krista L. Lanctôt +9 more
TL;DR: A meta-analysis of studies measuring cytokine concentration in patients with major depression reports significantly higher concentrations of the proinflammatory cytokines TNF-alpha and IL-6 in depressed subjects compared with control subjects, strengthening evidence that depression is accompanied by activation of the IRS.
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The HPA axis in major depression: classical theories and new developments
TL;DR: It is shown that hyperactivity of the hypothalamic-pituitary-adrenal axis is one of the most consistent biological findings in major depression psychiatry, but the mechanisms underlying this abnormality are still unclear.