Candidate Genes Expression Profile Associated with Antidepressants Response in the GENDEP Study: Differentiating between Baseline ‘Predictors' and Longitudinal ‘Targets'
Annamaria Cattaneo,Massimo Gennarelli,Rudolf Uher,Gerome Breen,Anne Farmer,Katherine J. Aitchison,Katherine J. Aitchison,Ian W. Craig,Christoph Anacker,Patricia A Zunsztain,Peter McGuffin,Carmine M. Pariante +11 more
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In this article, the leukocyte mRNA expression levels of genes belonging to glucocorticoid receptor (GR) function (FKBP-4, FKBP-5, and GR), inflammatory cytokines (interleukin (IL)-1a, IL-1b), IL-6 and IL-7), macrophage inhibiting factor (MIF), and tumor necrosis factor (TNF)-a), were tested before and after 8 weeks of treatment with escitalopram or nortriptyline, as part of the Genome-About:
This article is published in Neuropsychopharmacology.The article was published on 2013-02-01 and is currently open access. It has received 342 citations till now. The article focuses on the topics: Proinflammatory cytokine.read more
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Genetic variations in the p11/tPA/BDNF pathway are associated with post stroke depression
Jinfeng Liang,Yingying Yue,Haitang Jiang,Deqin Geng,Jun Wang,Jianxin Lu,Shenghua Li,Kezhong Zhang,Aiqin Wu,Yonggui Yuan +9 more
TL;DR: Evidence is provided that the TrkB gene, BDNF and TrkB haplotypes, and gene-gene interactions between p11, tPA and BDNF are all associated with PSD, which suggests that genetic variations in the p11/tPA/BDNF pathway may play a central role in regulating the underlying mechanism of PSD.
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The BDNF Val(66)Met polymorphism is associated with escitalopram response in depressed patients.
Wissam El-Hage,Patrick Vourc'h,Philippe Gaillard,Julie Léger,Catherine Belzung,Yadira Ibarguen-Vargas,Christian R. Andres,Vincent Camus +7 more
TL;DR: A significant association between the BDNF valine to methionine substitution (Val66Met) polymorphism and the treatment response to escitalopram in a Caucasian population of severely depressed inpatients is highlighted.
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Behavioural and neurobiological consequences of macrophage migration inhibitory factor gene deletion in mice
Cecilie Bay-Richter,Shorena Janelidze,Analise Sauro,Richard Bucala,Jack W. Lipton,Tomas Deierborg,Lena Brundin,Lena Brundin +7 more
TL;DR: The findings support that MIF is involved in the generation of depressive-like symptoms, potentially by the effects of IFN-γ on dopamine metabolism and further suggests a sex-specific regulation of the involved mechanisms.
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Molecular serum signature of treatment resistant depression
Tillmann Ruland,Man K. Chan,Pawel Stocki,Laura Grosse,Matthias Rothermundt,Jason D. Cooper,Volker Arolt,Sabine Bahn +7 more
TL;DR: The findings suggest that proteins, which are involved in immune and complement activation, may represent potential biomarkers that could be used by clinicians to identify high-risk patients.
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Aiding and Abetting Anhedonia: Impact of Inflammation on the Brain and Pharmacological Implications.
Michael J. Lucido,Mandy Bekhbat,David R. Goldsmith,Michael T. Treadway,Ebrahim Haroon,Jennifer C. Felger,Andrew H. Miller +6 more
TL;DR: In this paper, the effects of inflammatory stimuli to humans and laboratory animals and chronic endogenous inflammatory states lead to motivational deficits and ultimately anhedonia, a core and disabling symptom of depression present in multiple other psychiatric disorders.
References
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