Candidate Genes Expression Profile Associated with Antidepressants Response in the GENDEP Study: Differentiating between Baseline ‘Predictors' and Longitudinal ‘Targets'
Annamaria Cattaneo,Massimo Gennarelli,Rudolf Uher,Gerome Breen,Anne Farmer,Katherine J. Aitchison,Katherine J. Aitchison,Ian W. Craig,Christoph Anacker,Patricia A Zunsztain,Peter McGuffin,Carmine M. Pariante +11 more
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In this article, the leukocyte mRNA expression levels of genes belonging to glucocorticoid receptor (GR) function (FKBP-4, FKBP-5, and GR), inflammatory cytokines (interleukin (IL)-1a, IL-1b), IL-6 and IL-7), macrophage inhibiting factor (MIF), and tumor necrosis factor (TNF)-a), were tested before and after 8 weeks of treatment with escitalopram or nortriptyline, as part of the Genome-About:
This article is published in Neuropsychopharmacology.The article was published on 2013-02-01 and is currently open access. It has received 342 citations till now. The article focuses on the topics: Proinflammatory cytokine.read more
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Childhood Trauma and Adulthood Inflammation: A Meta-Analysis of Peripheral C-reactive Protein, interleukin-6 and Tumour Necrosis factor-α
David Baumeister,Reece Akhtar,Simone Ciufolini,Simone Ciufolini,Carmine M. Pariante,Valeria Mondelli,Valeria Mondelli +6 more
TL;DR: It is demonstrated that childhood trauma contributes to a pro-inflammatory state in adulthood, with specific inflammatory profiles depending on the specific type of trauma.
Journal ArticleDOI
Inflammation: Depression Fans the Flames and Feasts on the Heat
TL;DR: When inflammation and depression co-occur, treating them in tandem may enhance recovery and reduce the risk of recurrence, suggesting that effective depression treatments could have a far-reaching impact on mood, inflammation, and health.
Journal ArticleDOI
Evidence-based guidelines for treating depressive disorders with antidepressants: A revision of the 2008 British Association for Psychopharmacology guidelines
Anthony J. Cleare,Carmine M. Pariante,Allan H. Young,Ian M. Anderson,D M B Christmas,Philip J. Cowen,Chris Dickens,I. N. Ferrier,John R. Geddes,Simon Gilbody,Peter M. Haddad,Cornelius Katona,Glyn Lewis,Andrea Malizia,RH McAllister-Williams,Paul Ramchandani,Jan Scott,David Taylor,Rudolf Uher +18 more
TL;DR: These guidelines cover the nature and detection of depressive disorders, acute treatment with antidepressant drugs, choice of drug versus alternative treatment, practical issues in prescribing and management, next-step treatment, relapse prevention, treatment of relapse and stopping treatment.
Journal ArticleDOI
Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression
Jennifer C. Felger,Zhihao Li,Ebrahim Haroon,Bobbi J. Woolwine,Moon Y. Jung,Xiaoping Hu,Andrew H. Miller +6 more
TL;DR: It is suggested that decreased corticostriatal connectivity may serve as a target for anti-inflammatory or pro-dopaminergic treatment strategies to improve motivational and motor deficits in patients with increased inflammation, including depression.
Journal ArticleDOI
Neuroinflammation and depression: A review
Romain Troubat,Pascal Barone,Samuel Leman,Thomas Desmidt,Arnaud Cressant,Boriana Atanasova,Bruno Brizard,Wissam El Hage,Alexandre Surget,Catherine Belzung,Vincent Camus +10 more
TL;DR: The intricated dynamic crosstalk between neuro inflammation and other relevant neurobiological correlates of depression add to evidence that neuroinflammation may be a key therapeutic target for future therapeutic strategies in major depressive disorder.
References
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