Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates.
Tiziana Rubino,Daniela Viganò,Natalia Realini,C. Guidali,Daniela Braida,Valeria Capurro,Chiara Castiglioni,Francesca Cherubino,Patrizia Romualdi,Sanzio Candeletti,Mariaelvina Sala,Daniela Parolaro +11 more
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TLDR
The results suggest that heavy cannabis consumption in adolescence may induce subtle alterations in the emotional circuit in female rats, ending in depressive-like behavior, whereas male rats show altered sensitivity to rewarding stimuli.About:
This article is published in Neuropsychopharmacology.The article was published on 2008-01-02 and is currently open access. It has received 317 citations till now. The article focuses on the topics: Ventral tegmental area & Nucleus accumbens.read more
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LACK OF INTERACTIONS BETWEEN PRENATAL IMMUNE ACTIVATION AND Δ<sup>9</sup>-TETRAHYDROCANNABINOL EXPOSURE DURING ADOLESCENCE IN BEHAVIOURS RELEVANT TO SYMPTOM DIMENSIONS OF SCHIZOPHRENIA IN RATS
TL;DR: In this paper , the authors used the maternal immune activation (MIA) model combined with THC exposure during adolescence to examine several behaviours in rats (working memory in the Y maze, sociability in the three-chamber test, sucrose preference as a measure, prepulse inhibition and formation of incidental associations) that are similar to the different symptom clusters of the disease.
Journal ArticleDOI
Experience with dronabinol consumption facilitated a stimulant effect of alcohol and affected alcohol-related changes in frontal cortical endocannabinoid levels in male rats
Cannabis Use and the Adolescent Brain
Lucy Albertella,Jan Copeland +1 more
TL;DR: This paper reviewed the current research in this area, including endocannabinoid influences on adolescent brain maturation and the types of impairments that have most been associated with adolescent cannabis use.
Journal ArticleDOI
Lasting effects of prenatal exposure to Cannabis in the retina of the offspring: an experimental study in mice.
Paulo Roberto Arruda Zantut,Mariana Matera Veras,Sarah Gomes Menezes Benevenutto,Angélica de Mendonça Vaz Safatle,Ricardo Augusto Pecora,Victor Yuji Yariwake,Janaína Iannicelli Torres,Gustavo Sakuno,Marco Martins,Aline Adriana Bolzan,Walter Yukihiko Takahashi,Paulo Hilário Nascimento Saldiva,Francisco Max Damico +12 more
TL;DR: In this paper, the impact of maternal Cannabis use on the retinal development and its postnatal consequences remains unknown, however, it is known that recreational use of Cannabis during pregnancy may alter retina structure in the offspring.
Posted ContentDOI
Testing The Role Of Δ9-Tetrahydrocannabinol During Adolescence As A Gateway Drug: Behavioural, Brain Imaging And Transcriptomic Studies
Javier Orihuel,Roberto Capellán,David Roura-Martínez,Marcos Ucha,L. Gomez-Rubio,C. Valverde,M. Casquero-Veiga,María Luisa Soto-Montenegro,Manuel Desco,Marta Oteo-Vives,M. Ibanez Moragues,N. Magro-Calvo,Miguel Ángel Morcillo,Emilio Ambrosio,Alejandro Higuera-Matas +14 more
TL;DR: The results suggest that adolescent THC exposure alters psychological and brain development and that the Gateway Hypothesis does not entirely pass the test of preclinical enquiry.
References
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The adolescent brain and age-related behavioral manifestations
TL;DR: Developmental changes in prefrontal cortex and limbic brain regions of adolescents across a variety of species, alterations that include an apparent shift in the balance between mesocortical and mesolimbic dopamine systems likely contribute to the unique characteristics of adolescence.
Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
TL;DR: Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.
Journal ArticleDOI
Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.
Deborah C. Rice,Stan Barone +1 more
TL;DR: Of critical concern is the possibility that developmental exposure to neurotoxicants may result in an acceleration of age-related decline in function, and the fact that developmental neurotoxicity that results in small effects can have a profound societal impact when amortized across the entire population and across the life span of humans.
Journal ArticleDOI
The use of a plus-maze to measure anxiety in the mouse
TL;DR: The plus-maze appears to be a useful test with which to investigate both anxiolytic and anxiogenic agents.
Journal ArticleDOI
The Mesolimbic Dopamine Reward Circuit in Depression
TL;DR: It is proposed that the NAc and VTA contribute importantly to the pathophysiology and symptomatology of depression and may even be involved in its etiology.
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