Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates.
Tiziana Rubino,Daniela Viganò,Natalia Realini,C. Guidali,Daniela Braida,Valeria Capurro,Chiara Castiglioni,Francesca Cherubino,Patrizia Romualdi,Sanzio Candeletti,Mariaelvina Sala,Daniela Parolaro +11 more
TLDR
The results suggest that heavy cannabis consumption in adolescence may induce subtle alterations in the emotional circuit in female rats, ending in depressive-like behavior, whereas male rats show altered sensitivity to rewarding stimuli.About:
This article is published in Neuropsychopharmacology.The article was published on 2008-01-02 and is currently open access. It has received 317 citations till now. The article focuses on the topics: Ventral tegmental area & Nucleus accumbens.read more
Citations
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Book ChapterDOI
How CB1 Receptor Activity and Distribution Contribute to Make the Male and Female Brain Different Toward Cannabinoid-Induced Effects
Silvia Antinori,Liana Fattore +1 more
TL;DR: This chapter provides an overview on the brain sexual dimorphism and the sex-dependent effects of cannabinoids, and reviews both clinical and laboratory-based research evidence revealing important sex-related differences in CB1 receptor level and function in different brain areas.
Journal ArticleDOI
Investigating the “two-hit hypothesis”: Effects of prenatal maternal immune activation and adolescent cannabis use on neurodevelopment in mice
Elisa Guma,Morton E. Tavel +1 more
TL;DR: In this paper , the authors examined whether combined exposure to prenatal MIA and adolescent delta-9-tetrahydrocannabinol (THC), the main psychoactive component of cannabis, lead to enduring neuroanatomical and behavioural changes in adulthood.
Journal ArticleDOI
Impact of Acute and Chronic Cannabis Use on Stress Response Regulation: Challenging the Belief That Cannabis Is an Effective Method for Coping.
Mustafa al'Absi,Alicia M. Allen +1 more
TL;DR: In this paper, the influence of acute and chronic exposure to cannabis on patterns and regulation of the stress response is examined. But, the authors highlight the role of stress as a risk factor for initiation and maintenance of cannabis use.
Journal ArticleDOI
Development of anxiety‐like behaviors during adolescence: Persistent effects of adolescent morphine exposure in male rats
TL;DR: In this paper , the effects of sustained opioid exposure during adolescence on anxiety-like behaviors were investigated in Wistar male rats, and they found that chronic adolescent morphine exposure reduced the weight gain during the period of morphine treatment and 4 weeks after that.
Journal ArticleDOI
Cocaine-induced Fos expression in the rat brain: Modulation by prior Δ9-tetrahydrocannabinol exposure during adolescence and sex-specific effects
Javier Orihuel,Laura Gómez-Rubio,Claudia Valverde,Roberto Capellán,David Roura-Martínez,Marcos Ucha,Emilio Ambrosio,Alejandro Higuera-Matas +7 more
TL;DR: For instance, this paper found that adolescent exposure to cannabinoids (both natural and synthetic) potentiates cocaine self-administration in rats, and that the motor cortex activation was stronger in THC-exposed rats.
References
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Journal ArticleDOI
The adolescent brain and age-related behavioral manifestations
TL;DR: Developmental changes in prefrontal cortex and limbic brain regions of adolescents across a variety of species, alterations that include an apparent shift in the balance between mesocortical and mesolimbic dopamine systems likely contribute to the unique characteristics of adolescence.
Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
TL;DR: Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.
Journal ArticleDOI
Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.
Deborah C. Rice,Stan Barone +1 more
TL;DR: Of critical concern is the possibility that developmental exposure to neurotoxicants may result in an acceleration of age-related decline in function, and the fact that developmental neurotoxicity that results in small effects can have a profound societal impact when amortized across the entire population and across the life span of humans.
Journal ArticleDOI
The use of a plus-maze to measure anxiety in the mouse
TL;DR: The plus-maze appears to be a useful test with which to investigate both anxiolytic and anxiogenic agents.
Journal ArticleDOI
The Mesolimbic Dopamine Reward Circuit in Depression
TL;DR: It is proposed that the NAc and VTA contribute importantly to the pathophysiology and symptomatology of depression and may even be involved in its etiology.
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Chronic pubertal, but not adult chronic cannabinoid treatment impairs sensorimotor gating, recognition memory, and the performance in a progressive ratio task in adult rats.
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