Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates.
Tiziana Rubino,Daniela Viganò,Natalia Realini,C. Guidali,Daniela Braida,Valeria Capurro,Chiara Castiglioni,Francesca Cherubino,Patrizia Romualdi,Sanzio Candeletti,Mariaelvina Sala,Daniela Parolaro +11 more
TLDR
The results suggest that heavy cannabis consumption in adolescence may induce subtle alterations in the emotional circuit in female rats, ending in depressive-like behavior, whereas male rats show altered sensitivity to rewarding stimuli.About:
This article is published in Neuropsychopharmacology.The article was published on 2008-01-02 and is currently open access. It has received 317 citations till now. The article focuses on the topics: Ventral tegmental area & Nucleus accumbens.read more
Citations
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Estradiol signaling in the regulation of reproduction and energy balance
Kevin Sinchak,Edward J. Wagner +1 more
TL;DR: This review focuses on the current understanding of estrogenic signaling mechanisms to promote: (1) sexual receptivity within the arcuate nucleus of the hypothalamus, (2) estrogen positive feedback that stimulates de novo neuroprogesterone synthesis to trigger the luteinizing hormone surge important for ovulation and estrous cyclicity, and (3) alterations in energy balance.
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Sex differences in Δ9-tetrahydrocannabinol metabolism and in vivo pharmacology following acute and repeated dosing in adolescent rats
Jenny L. Wiley,James J. Burston +1 more
TL;DR: The present results suggest that sex differences in pharmacokinetics cannot fully explain the patterns of sex Differences in cannabinoid effects across behaviors, and Hormonal and/or pharmacodynamic factors are also likely to play a role.
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AKT1 genotype moderates the acute psychotomimetic effects of naturalistically smoked cannabis in young cannabis smokers
TL;DR: These findings are the first to demonstrate that AKT1 mediates the acute response to cannabis in otherwise healthy individuals and implicate theAKT1 pathway as a possible target for prevention and treatment of cannabis psychosis.
Journal ArticleDOI
Longitudinal influence of alcohol and marijuana use on academic performance in college students.
Shashwath A. Meda,Ralitza Gueorguieva,Brian Pittman,Rivkah I. Rosen,Farah Aslanzadeh,Howard Tennen,Samantha Leen,Keith A. Hawkins,Sarah A. Raskin,Rebecca M. Wood,Carol Shaw Austad,Alecia D. Dager,Carolyn R. Fallahi,Godfrey D. Pearlson +13 more
TL;DR: This study validates and extends the current literature by providing important implications of concurrent alcohol and marijuana use on academic achievement in college by predicting grade point average (GPA) in three data-driven clusters.
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Cortical neuroinflammation contributes to long-term cognitive dysfunctions following adolescent delta-9-tetrahydrocannabinol treatment in female rats.
TL;DR: It is demonstrated that adolescent THC administration is associated with persistent neuroinflammation within the PFC and evidence is provided for a causal association between microglial activation and the development long-term cognitive deficits induced by adolescent THC treatment.
References
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The adolescent brain and age-related behavioral manifestations
TL;DR: Developmental changes in prefrontal cortex and limbic brain regions of adolescents across a variety of species, alterations that include an apparent shift in the balance between mesocortical and mesolimbic dopamine systems likely contribute to the unique characteristics of adolescence.
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Behavioural despair in rats: a new model sensitive to antidepressant treatments.
TL;DR: Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.
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Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.
Deborah C. Rice,Stan Barone +1 more
TL;DR: Of critical concern is the possibility that developmental exposure to neurotoxicants may result in an acceleration of age-related decline in function, and the fact that developmental neurotoxicity that results in small effects can have a profound societal impact when amortized across the entire population and across the life span of humans.
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The use of a plus-maze to measure anxiety in the mouse
TL;DR: The plus-maze appears to be a useful test with which to investigate both anxiolytic and anxiogenic agents.
Journal ArticleDOI
The Mesolimbic Dopamine Reward Circuit in Depression
TL;DR: It is proposed that the NAc and VTA contribute importantly to the pathophysiology and symptomatology of depression and may even be involved in its etiology.
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