Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates.
Tiziana Rubino,Daniela Viganò,Natalia Realini,C. Guidali,Daniela Braida,Valeria Capurro,Chiara Castiglioni,Francesca Cherubino,Patrizia Romualdi,Sanzio Candeletti,Mariaelvina Sala,Daniela Parolaro +11 more
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TLDR
The results suggest that heavy cannabis consumption in adolescence may induce subtle alterations in the emotional circuit in female rats, ending in depressive-like behavior, whereas male rats show altered sensitivity to rewarding stimuli.About:
This article is published in Neuropsychopharmacology.The article was published on 2008-01-02 and is currently open access. It has received 317 citations till now. The article focuses on the topics: Ventral tegmental area & Nucleus accumbens.read more
Citations
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Adolescent cannabinoid exposure induces irritability-like behavior and cocaine cross-sensitization without affecting the escalation of cocaine self-administration in adulthood.
Jenni Kononoff,Philippe A. Melas,Philippe A. Melas,Marsida Kallupi,Giordano de Guglielmo,Adam Kimbrough,Maria Scherma,Paola Fadda,Denise B. Kandel,Eric R. Kandel,Eric R. Kandel,Olivier George +11 more
TL;DR: The results suggest that psychoactive cannabinoid exposure during adolescence is unlikely to have a major effect on the escalation of cocaine intake or the development of compulsive-like responding per se in adulthood in a rat model of cocaine self-administration, however, whether the persisting irritability-like behavior may predispose an individual to mood-related impairments in adulthood or predict such impairments warrants further investigation.
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A Systematic Review of Human Neuroimaging Evidence of Memory-Related Functional Alterations Associated With Cannabis Use Complemented With Preclinical and Human Evidence of Memory Performance Alterations
TL;DR: A systematic review of functional magnetic resonance imaging studies investigating brain functional alterations in cannabis users (CU) compared to nonusing controls while performing memory tasks, complemented with focused narrative reviews of relevant preclinical and human studies.
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Advancing the science on cannabis concentrates and behavioural health.
TL;DR: A review of the state of the research on concentrated cannabis concentrates and behavioural health-related outcomes is presented in this paper, where the authors make recommendations for advancing the science with studies focused on accurately testing the risks in relation to critical public and behavioral health questions.
Journal ArticleDOI
Modulatory influences of estradiol and other anorexigenic hormones on metabotropic, Gi/o-coupled receptor function in the hypothalamic control of energy homeostasis.
TL;DR: It is demonstrated that the fasting-induced hyperphagia observed in ORL1-null mice is blunted compared to wild type controls, and leptin robustly suppresses the OFQ/N-induced activation of GIRK channels in POMC neurons.
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Combined ∆9-tetrahydrocannabinol and moderate alcohol administration: effects on ingestive behaviors in adolescent male rats.
Nnamdi G. Nelson,Wen Xuan Law,Michael J. Weingarten,Lauren N. Carnevale,Aditi Das,Nu Chu Liang +5 more
TL;DR: A novel model of voluntary alcohol and THC consumption is established for studying mechanisms underlying the consequences of adolescent onset co-use of the two drugs.
References
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The adolescent brain and age-related behavioral manifestations
TL;DR: Developmental changes in prefrontal cortex and limbic brain regions of adolescents across a variety of species, alterations that include an apparent shift in the balance between mesocortical and mesolimbic dopamine systems likely contribute to the unique characteristics of adolescence.
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Behavioural despair in rats: a new model sensitive to antidepressant treatments.
TL;DR: Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.
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Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.
Deborah C. Rice,Stan Barone +1 more
TL;DR: Of critical concern is the possibility that developmental exposure to neurotoxicants may result in an acceleration of age-related decline in function, and the fact that developmental neurotoxicity that results in small effects can have a profound societal impact when amortized across the entire population and across the life span of humans.
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The use of a plus-maze to measure anxiety in the mouse
TL;DR: The plus-maze appears to be a useful test with which to investigate both anxiolytic and anxiogenic agents.
Journal ArticleDOI
The Mesolimbic Dopamine Reward Circuit in Depression
TL;DR: It is proposed that the NAc and VTA contribute importantly to the pathophysiology and symptomatology of depression and may even be involved in its etiology.
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