Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates.
Tiziana Rubino,Daniela Viganò,Natalia Realini,C. Guidali,Daniela Braida,Valeria Capurro,Chiara Castiglioni,Francesca Cherubino,Patrizia Romualdi,Sanzio Candeletti,Mariaelvina Sala,Daniela Parolaro +11 more
TLDR
The results suggest that heavy cannabis consumption in adolescence may induce subtle alterations in the emotional circuit in female rats, ending in depressive-like behavior, whereas male rats show altered sensitivity to rewarding stimuli.About:
This article is published in Neuropsychopharmacology.The article was published on 2008-01-02 and is currently open access. It has received 317 citations till now. The article focuses on the topics: Ventral tegmental area & Nucleus accumbens.read more
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Journal ArticleDOI
Sex-dependent effects of maternal deprivation and adolescent cannabinoid treatment on adult rat behaviour
Alvaro Llorente-Berzal,Silvia Fuentes,Humberto Gagliano,Meritxell López-Gallardo,Antonio Armario,Maria-Paz Viveros,Roser Nadal +6 more
TL;DR: The present results indicate that early MD and adolescent cannabinoid exposure exerted distinct sex‐dependent long‐term behavioural and physiological modifications that could predispose to the development of certain neuropsychiatric disorders, though no synergistic effects were found.
Journal ArticleDOI
Effects of Δ9-THC and cannabidiol vapor inhalation in male and female rats
Mehrak Javadi-Paydar,Jacques D. Nguyen,Tony M. Kerr,Yanabel Grant,Sophia A. Vandewater,Maury Cole,Michael A. Taffe +6 more
TL;DR: The inhalation of THC or CBD, alone and in combination, produces approximately equivalent effects in male and female rats, confirming the efficacy of the e-cigarette-based method of THC delivery in female rats.
Journal ArticleDOI
Behavioral disinhibition and reduced anxiety-like behaviors in monoamine oxidase B deficient mice
TL;DR: Results suggest that MAO B deficiency may lead to behavioral disinhibition and decreased anxiety-like responses partially through regional increases of PEA levels.
Book ChapterDOI
Endocannabinoid System Components: Overview and Tissue Distribution.
Neal Joshi,Emmanuel S. Onaivi +1 more
TL;DR: The components and tissue distribution of this previously unknown but ubiquitous and complex ECS that is involved in almost all aspects of mammalian physiology and pathology are reviewed.
Journal ArticleDOI
HMGB1 mediates depressive behavior induced by chronic stress through activating the kynurenine pathway
Bo Wang,Yong-Jie Lian,Wen-Jun Su,Wei Peng,Xin Dong,Lin-Lin Liu,Hong Gong,Ting Zhang,Chun-Lei Jiang,Yun-Xia Wang +9 more
TL;DR: The role of HMGB1 on the induction of depressive behavior is mediated by KP activation, and the gene transcription of kynurenine monooxygenase (KMO) andKynureninase (KYNU) in the downstream of KP also increased both in vivo and in vitro.
References
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Journal ArticleDOI
The adolescent brain and age-related behavioral manifestations
TL;DR: Developmental changes in prefrontal cortex and limbic brain regions of adolescents across a variety of species, alterations that include an apparent shift in the balance between mesocortical and mesolimbic dopamine systems likely contribute to the unique characteristics of adolescence.
Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
TL;DR: Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.
Journal ArticleDOI
Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.
Deborah C. Rice,Stan Barone +1 more
TL;DR: Of critical concern is the possibility that developmental exposure to neurotoxicants may result in an acceleration of age-related decline in function, and the fact that developmental neurotoxicity that results in small effects can have a profound societal impact when amortized across the entire population and across the life span of humans.
Journal ArticleDOI
The use of a plus-maze to measure anxiety in the mouse
TL;DR: The plus-maze appears to be a useful test with which to investigate both anxiolytic and anxiogenic agents.
Journal ArticleDOI
The Mesolimbic Dopamine Reward Circuit in Depression
TL;DR: It is proposed that the NAc and VTA contribute importantly to the pathophysiology and symptomatology of depression and may even be involved in its etiology.
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Chronic pubertal, but not adult chronic cannabinoid treatment impairs sensorimotor gating, recognition memory, and the performance in a progressive ratio task in adult rats.
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