Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates.
Tiziana Rubino,Daniela Viganò,Natalia Realini,C. Guidali,Daniela Braida,Valeria Capurro,Chiara Castiglioni,Francesca Cherubino,Patrizia Romualdi,Sanzio Candeletti,Mariaelvina Sala,Daniela Parolaro +11 more
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TLDR
The results suggest that heavy cannabis consumption in adolescence may induce subtle alterations in the emotional circuit in female rats, ending in depressive-like behavior, whereas male rats show altered sensitivity to rewarding stimuli.About:
This article is published in Neuropsychopharmacology.The article was published on 2008-01-02 and is currently open access. It has received 317 citations till now. The article focuses on the topics: Ventral tegmental area & Nucleus accumbens.read more
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Maternal deprivation and adolescent cannabinoid exposure impact hippocampal astrocytes, CB1 receptors and brain-derived neurotrophic factor in a sexually dimorphic fashion.
Meritxell López-Gallardo,Ana Belen Lopez-Rodriguez,Ana Belen Lopez-Rodriguez,Alvaro Llorente-Berzal,Alvaro Llorente-Berzal,David Rotllant,Ken Mackie,Antonio Armario,Roser Nadal,Maria-Paz Viveros,Maria-Paz Viveros +10 more
TL;DR: The present results show sex-dependent long-term effects of both MD and juvenile cannabinoid exposure as well as functional interactions between the two treatments.
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Associations between anhedonia and marijuana use escalation across mid-adolescence.
Adam M. Leventhal,Junhan Cho,Matthew D. Stone,Jessica L. Barrington-Trimis,Chih-Ping Chou,Steven Sussman,Nathaniel R. Riggs,Jennifer B. Unger,Janet Audrain-McGovern,David R. Strong +9 more
TL;DR: In mid-adolescence, anhedonia is associated with subsequentarijuana use escalation, but marijuana use escalation does not appear to be associated withsequent anhedonian.
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Altering endocannabinoid neurotransmission at critical developmental ages: impact on rodent emotionality and cognitive performance.
Viviana Trezza,Patrizia Campolongo,Antonia Manduca,Maria Morena,Maura Palmery,Louk J. M. J. Vanderschuren,Vincenzo Cuomo +6 more
TL;DR: This work addresses the issue of developmental exposure to cannabinoid compounds induces enduring changes in behaviors and neural processes belonging to the cognitive and emotional domains in adolescent cannabis users by focusing on rodent studies, in order to provide a framework for understanding the impact of cannabinoid exposure on the developing brain.
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Cannabis and development of dual diagnoses: A literature review.
TL;DR: There is substantial evidence of cannabis use leading to other illicit drug use and of an association between cannabis use and psychosis and a few reports suggest an association with bipolar disorder while the association with depression and anxiety disorders is mixed.
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Mechanisms Underlying Sex Differences in Cannabis Use.
TL;DR: Understanding the neurobiological mechanisms of cannabis exposure in females and males is key to help inform future research on sex-specific pharmacological and behavioral interventions for women and men with high-risk cannabis use, comorbid psychiatric disease, and CUD.
References
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The adolescent brain and age-related behavioral manifestations
TL;DR: Developmental changes in prefrontal cortex and limbic brain regions of adolescents across a variety of species, alterations that include an apparent shift in the balance between mesocortical and mesolimbic dopamine systems likely contribute to the unique characteristics of adolescence.
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Behavioural despair in rats: a new model sensitive to antidepressant treatments.
TL;DR: Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.
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Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.
Deborah C. Rice,Stan Barone +1 more
TL;DR: Of critical concern is the possibility that developmental exposure to neurotoxicants may result in an acceleration of age-related decline in function, and the fact that developmental neurotoxicity that results in small effects can have a profound societal impact when amortized across the entire population and across the life span of humans.
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The use of a plus-maze to measure anxiety in the mouse
TL;DR: The plus-maze appears to be a useful test with which to investigate both anxiolytic and anxiogenic agents.
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The Mesolimbic Dopamine Reward Circuit in Depression
TL;DR: It is proposed that the NAc and VTA contribute importantly to the pathophysiology and symptomatology of depression and may even be involved in its etiology.
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