Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates.
Tiziana Rubino,Daniela Viganò,Natalia Realini,C. Guidali,Daniela Braida,Valeria Capurro,Chiara Castiglioni,Francesca Cherubino,Patrizia Romualdi,Sanzio Candeletti,Mariaelvina Sala,Daniela Parolaro +11 more
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TLDR
The results suggest that heavy cannabis consumption in adolescence may induce subtle alterations in the emotional circuit in female rats, ending in depressive-like behavior, whereas male rats show altered sensitivity to rewarding stimuli.About:
This article is published in Neuropsychopharmacology.The article was published on 2008-01-02 and is currently open access. It has received 317 citations till now. The article focuses on the topics: Ventral tegmental area & Nucleus accumbens.read more
Citations
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Antidepressant-Like Activity and Modulation of Brain Monoaminergic Transmission by Blockade of Anandamide Hydrolysis
Gabriella Gobbi,Francis Rodriguez Bambico,Regina A. Mangieri,Marco Bortolato,Patrizia Campolongo,Tommaso Cassano,Maria Grazia Morgese,Guy Debonnel,Andrea Duranti,A. Tontini,Giorgio Tarzia,Marco Mor,Viviana Trezza,Steven R. Goldberg,Vincenzo Cuomo,Daniele Piomelli +15 more
TL;DR: Gobi et al. as discussed by the authors showed that URB597, a selective inhibitor of the enzyme fatty acid amide hydrolase, which catalyzes the intracellular hydrolysis of the endocannabinoid anandamide, exerts potent antidepressant-like effects in the mouse tail-suspension test and the rat forced-swim test.
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From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology
TL;DR: This review article aims to describe and critically discuss the pharmacology and potential impact on mammalian physiology of all major phytocannabinoids, and not only of the most famous one Δ(9)-tetrahydrocannabinol, and the adaptive pro-homeostatic physiological, or maladaptive pathological, roles of the ECS in mammalian cells, tissues, and organs.
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Keep off the grass? Cannabis, cognition and addiction
H. Valerie Curran,Tom P. Freeman,Claire Mokrysz,David A. Lewis,Celia J. A. Morgan,Celia J. A. Morgan,Loren H. Parsons +6 more
TL;DR: The current state of knowledge about vulnerability factors, the variations in types of cannabis, and the relationship between these and cognition and addiction are reviewed.
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Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study.
Alexander Neumeister,Marc D. Normandin,Marc D. Normandin,Robert H. Pietrzak,Robert H. Pietrzak,Daniele Piomelli,Ming-Qiang Zheng,Ana Gujarro-Anton,Marc N. Potenza,Christopher R. Bailey,Shu-fei Lin,Soheila Najafzadeh,Jim Ropchan,Shannan Henry,Stefani Corsi-Travali,Richard E. Carson,Yiyun Huang +16 more
TL;DR: It is suggested that abnormal CB1 receptor-mediated anandamide signaling is implicated in the etiology of PTSD, and provide a promising neurobiological model to develop novel, evidence-based pharmacotherapies for this disorder.
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Effects of Cannabis on Neurocognitive Functioning: Recent Advances, Neurodevelopmental Influences, and Sex Differences
TL;DR: The purpose of this review was to provide an update on research of cannabis’ acute and non-acute effects on neurocognition, with a focus on findings since 2007, and suggest and discuss how neurodevelopmental issues and sex differences may influence cannabis effects on neuroscience.
References
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Journal ArticleDOI
Endocannabinoids and the control of energy balance
Isabel Matias,Vincenzo Di Marzo +1 more
TL;DR: Two receptors have been cloned to date for the psychotropic compound Delta(9)-tetrahydrocannabinol, and termed cannabinoid CB(1) and CB(2) receptors, and their endogenous ligands, the endocannabinoids, have been identified.
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Inhibition of cAMP Response Element-Binding Protein or Dynorphin in the Nucleus Accumbens Produces an Antidepressant-Like Effect
Samuel S. Newton,Johannes Thome,Tanya L. Wallace,Yukihikko Shirayama,Lee Schlesinger,Norio Sakai,Jingshan Chen,Rachael L. Neve,Eric J. Nestler,Ronald S. Duman +9 more
TL;DR: The results demonstrate that nucleus accumbens CREB–dynorphin influence behavior in the learned helplessness model and suggest that this signaling cascade may contribute to symptoms of depression.
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Effects of Chronic Treatment with Δ9-Tetrahydrocannabinol on Cannabinoid-Stimulated [35S]GTPγS Autoradiography in Rat Brain
TL;DR: In vitro autoradiography of agonist-stimulated [35S]GTPγS binding is used to localize cannabinoid receptor-activated G-proteins after chronic Δ9-THC treatment to suggest that profound desensitization of cannabinoid-activated signal transduction mechanisms occurs after chronic cannabinoids treatment.
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Adolescent rats find repeated Delta(9)-THC less aversive than adult rats but display greater residual cognitive deficits and changes in hippocampal protein expression following exposure.
Heidi R Quinn,Izuru Matsumoto,Paul D. Callaghan,Leonora E. Long,Jonathon C. Arnold,Nathan Gunasekaran,Murray R. Thompson,Bronwyn Dawson,Paul E. Mallet,Mohammed Abul Kashem,Haruka Matsuda-Matsumoto,Takeshi Iwazaki,Iain S. McGregor +12 more
TL;DR: It is suggested that adolescent rats find repeated Δ9-THC exposure less aversive than adults, but that cannabinoid exposure causes greater lasting memory deficits and hippocampal alterations in adolescent than adult rats.
Journal ArticleDOI
Inhibition of restraint stress-induced neural and behavioural activation by endogenous cannabinoid signalling.
TL;DR: The data suggest that eCB activation of CB1 receptors opposes the behavioural and neuronal responses to aversive stimuli and hypothesize that increased CB1 receptor activity contributes to the expression of habituation to homotypic stress.
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