Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates.
Tiziana Rubino,Daniela Viganò,Natalia Realini,C. Guidali,Daniela Braida,Valeria Capurro,Chiara Castiglioni,Francesca Cherubino,Patrizia Romualdi,Sanzio Candeletti,Mariaelvina Sala,Daniela Parolaro +11 more
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TLDR
The results suggest that heavy cannabis consumption in adolescence may induce subtle alterations in the emotional circuit in female rats, ending in depressive-like behavior, whereas male rats show altered sensitivity to rewarding stimuli.About:
This article is published in Neuropsychopharmacology.The article was published on 2008-01-02 and is currently open access. It has received 317 citations till now. The article focuses on the topics: Ventral tegmental area & Nucleus accumbens.read more
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Age of onset of heaviest use of cannabis or alcohol in persons with severe opioid or cocaine use disorders
TL;DR: This observational study examined the ages of onset of heaviest use of cannabis and alcohol in persons diagnosed by DSM-IV criteria with opioid dependence, both opioid and cocaine dependence (OD + CD) and drug dependence (CD).
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Long-term effects of THC exposure on reward learning and motivated behavior in adolescent and adult male rats
TL;DR: This paper found that repeated THC exposure (5 mg/kg/day for 14 days) during adolescence or adulthood led to long-term changes in rats' capacity to flexibly encode and use action-outcome associations for goal-directed decision making.
Research Article A study of the neurotoxic effects of tramadol and cannabis in adolescent male albino rats
TL;DR: abuse of tramadol or cannabis, alone and in combination, caused antidepressant effect, impaired spatial memory, elevated serotonin levels in the cerebral cortex and hippocampus, induced oxidative stress, and deleteriously altered brain histopathology in adolescent male albino rats.
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Sex differences in the behavioral and synaptic consequences of a single exposure to cannabinoid at puberty and adulthood
Milene Borsoi,Antonia Manduca,Anissa Bara,Olivier Lassalle,Anne-Laure Pelissier-Alicot,Olivier J. Manzoni +5 more
TL;DR: Assessing social behavior and PFC neuronal and synaptic functions in rats during pubertal or adulthood periods, 24h after a single in-vivo cannabinoid exposure (SCE) indicates behavioral and synaptic sex differences in response to asingle in- vivo exposure to cannabinoid at puberty and adulthood.
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Alterações na percepção emocional em usuários de cannabis
TL;DR: Evidence suggest that it occurs desensibilization of perception related to potentially stressing stimuli that may be relevant for psychopathology development and for addiction to this substance.
References
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The adolescent brain and age-related behavioral manifestations
TL;DR: Developmental changes in prefrontal cortex and limbic brain regions of adolescents across a variety of species, alterations that include an apparent shift in the balance between mesocortical and mesolimbic dopamine systems likely contribute to the unique characteristics of adolescence.
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Behavioural despair in rats: a new model sensitive to antidepressant treatments.
TL;DR: Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.
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Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.
Deborah C. Rice,Stan Barone +1 more
TL;DR: Of critical concern is the possibility that developmental exposure to neurotoxicants may result in an acceleration of age-related decline in function, and the fact that developmental neurotoxicity that results in small effects can have a profound societal impact when amortized across the entire population and across the life span of humans.
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The use of a plus-maze to measure anxiety in the mouse
TL;DR: The plus-maze appears to be a useful test with which to investigate both anxiolytic and anxiogenic agents.
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The Mesolimbic Dopamine Reward Circuit in Depression
TL;DR: It is proposed that the NAc and VTA contribute importantly to the pathophysiology and symptomatology of depression and may even be involved in its etiology.
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Chronic pubertal, but not adult chronic cannabinoid treatment impairs sensorimotor gating, recognition memory, and the performance in a progressive ratio task in adult rats.
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