Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates.
Tiziana Rubino,Daniela Viganò,Natalia Realini,C. Guidali,Daniela Braida,Valeria Capurro,Chiara Castiglioni,Francesca Cherubino,Patrizia Romualdi,Sanzio Candeletti,Mariaelvina Sala,Daniela Parolaro +11 more
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TLDR
The results suggest that heavy cannabis consumption in adolescence may induce subtle alterations in the emotional circuit in female rats, ending in depressive-like behavior, whereas male rats show altered sensitivity to rewarding stimuli.About:
This article is published in Neuropsychopharmacology.The article was published on 2008-01-02 and is currently open access. It has received 317 citations till now. The article focuses on the topics: Ventral tegmental area & Nucleus accumbens.read more
Citations
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Journal ArticleDOI
Dose mediates the protracted effects of adolescent THC exposure on reward and stress reactivity in males relevant to perturbation of the basolateral amygdala transcriptome
Jacqueline-Marie N. Ferland,Randall J. Ellis,Gregory R. Rompala,Joseph A. Landry,James E. Callens,Annie Ly,Micah D. Frier,Teddy O. Uzamere,Yasmin L. Hurd +8 more
TL;DR: The findings emphasize the importance of dose and behavioral state on the presentation of THC-related behavioral phenotypes in adulthood and dysregulation of astrocytes as an interface for the protracted effects of high dose THC and subsequent stress sensitivity.
Journal ArticleDOI
Changes in brain structure and function following chronic exposure to inhaled vaporised cannabis during periadolescence in female and male mice: A multimodal MRI study
James R. Coleman,Dan Madularu,Richard J. Ortiz,Maria Athanassiou,Alexa Knudsen,Ilayda Alkislar,Xuezhu Cai,Praveen Kulkarni,Bruce S. Cushing,Craig F. Ferris +9 more
TL;DR: The aim of this study was to assess any sex‐based neurobiological effects of chronically inhaled, vaporised cannabis on adolescent female and male mice.
Journal ArticleDOI
Long-Term Outcomes of Adolescent THC Exposure on Translational Cognitive Measures in Adulthood in an Animal Model and Computational Assessment of Human Data.
Jacqueline-Marie N. Ferland,Randall J. Ellis,Graeme D Betts,Mason M. Silveira,Joao Bronze de Firmino,Catharine A. Winstanley,Yasmin L. Hurd +6 more
TL;DR: In this paper , a translational rat study was conducted to evaluate the long-term outcomes of adolescent THC exposure on adult decision-making and impulse control in a rat model and found that high-dose adolescent exposure was associated with cognitive vulnerability in adulthood, especially with THC re-exposure.
Journal ArticleDOI
Adolescent cannabinoid exposure modulates the vulnerability to cocaine-induced conditioned place preference and DNMT3a expression in the prefrontal cortex in Swiss mice
P H Gobira,A L Roncalho,Nicole Rodrigues da Silva,Gabriela Pandini Silote,Amanda J. Sales,Samia R. L. Joca,Samia R. L. Joca +6 more
TL;DR: Findings suggest that exposure to WIN55,212-2 during adolescence leads to changes in DNMT3a expression, and this pathway appears to be relevant to modulating the rewarding effects of cocaine.
Book ChapterDOI
Age-dependent effects of cannabinoids on neurophysiological, emotional, and motivational states
Maria-Paz Viveros,Eva M. Marco +1 more
TL;DR: Interference of endocannabinoid signalling by cannabis exposure may contribute to explain the enduring negative impact of cannabis on neurodevelopmental processes and the resulting psycho-physio-pathological consequences.
References
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Journal ArticleDOI
The adolescent brain and age-related behavioral manifestations
TL;DR: Developmental changes in prefrontal cortex and limbic brain regions of adolescents across a variety of species, alterations that include an apparent shift in the balance between mesocortical and mesolimbic dopamine systems likely contribute to the unique characteristics of adolescence.
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Behavioural despair in rats: a new model sensitive to antidepressant treatments.
TL;DR: Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.
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Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.
Deborah C. Rice,Stan Barone +1 more
TL;DR: Of critical concern is the possibility that developmental exposure to neurotoxicants may result in an acceleration of age-related decline in function, and the fact that developmental neurotoxicity that results in small effects can have a profound societal impact when amortized across the entire population and across the life span of humans.
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The use of a plus-maze to measure anxiety in the mouse
TL;DR: The plus-maze appears to be a useful test with which to investigate both anxiolytic and anxiogenic agents.
Journal ArticleDOI
The Mesolimbic Dopamine Reward Circuit in Depression
TL;DR: It is proposed that the NAc and VTA contribute importantly to the pathophysiology and symptomatology of depression and may even be involved in its etiology.
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