Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates.
Tiziana Rubino,Daniela Viganò,Natalia Realini,C. Guidali,Daniela Braida,Valeria Capurro,Chiara Castiglioni,Francesca Cherubino,Patrizia Romualdi,Sanzio Candeletti,Mariaelvina Sala,Daniela Parolaro +11 more
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TLDR
The results suggest that heavy cannabis consumption in adolescence may induce subtle alterations in the emotional circuit in female rats, ending in depressive-like behavior, whereas male rats show altered sensitivity to rewarding stimuli.About:
This article is published in Neuropsychopharmacology.The article was published on 2008-01-02 and is currently open access. It has received 317 citations till now. The article focuses on the topics: Ventral tegmental area & Nucleus accumbens.read more
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Chronic nandrolone decanoate exposure during adolescence affects emotional behavior and monoaminergic neurotransmission in adulthood.
Quentin Rainer,Simona Speziali,Tiziana Rubino,Sergio Dominguez-Lopez,Francis Rodriguez Bambico,Gabriella Gobbi,Daniela Parolaro +6 more
TL;DR: Evidence is provided that nandrolone decanoate exposure during adolescence alters the emotional profile of animals in adulthood and significantly modifies both serotonergic and noradrenergic neurotransmission.
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Role of Cannabinoid Receptor Type 1 Desensitization in Greater Tetrahydrocannabinol Impairment of Memory in Adolescent Rats
Nicole L.T. Moore,Ashley L. R. Greenleaf,Shawn K. Acheson,Wilkie A. Wilson,H. Scott Swartzwelder,Cynthia M. Kuhn +5 more
TL;DR: The results indicate that adults, but not adolescents, become tolerant to the effects of THC during water maze training after 5 days of pretreatment, and CB1s in adolescent hippocampus are less functionally coupled to G proteins and desensitize more slowly in response to THC treatment than those of adults.
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Ginsenoside Rg1-induced antidepressant effects involve the protection of astrocyte gap junctions within the prefrontal cortex
Can Jin,Zhen-Zhen Wang,Heng Zhou,Yu Xia Lou,Jiao Chen,Wei Zuo,Man Tong Tian,Zhi Qi Wang,Guo Hua Du,Ichiro Kawahata,Tohru Yamakuni,Yi Zhang,Nai Hong Chen,Nai Hong Chen,Dan Shen Zhang,Dan Shen Zhang +15 more
TL;DR: The results demonstrate that Rg1‐induced antidepressant effects are might be mediated, in part, by protecting astrocyte gap junctions within the prefrontal cortex, indicating beneficial effects on the functional activity of gap junction channels in the brain.
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Adolescent cannabinoid exposure effects on natural reward seeking and learning in rats
Hannah Schoch,M. Y. Huerta,Christina M. Ruiz,Mitchell R. Farrell,Kwang-Mook Jung,J. J. Huang,R. R. Campbell,Daniele Piomelli,Stephen V. Mahler +8 more
TL;DR: These results demonstrate that ACRS causes long-term increases in natural reward-seeking behaviors and ECB system function that persist into adulthood, potentially increasing liability to excessive natural reward seeking later in life.
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A Comparative, Developmental, and Clinical Perspective of Neurobehavioral Sexual Dimorphisms
Maria-Paz Viveros,Adriana Mendrek,Tomáš Paus,Tomáš Paus,Ana Belen Lopez-Rodriguez,Eva M. Marco,Rachel Yehuda,Rachel Yehuda,Hagit Cohen,Amy Lehrner,Edward J. Wagner +10 more
TL;DR: In this paper, a comparative view of the central nervous system of vertebrates with respect to sexual differences in brain structure from birth, through adolescence, to adulthood has been presented with a brief overview of sex-chromosome pathways underlying sexual dimorphisms.
References
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The adolescent brain and age-related behavioral manifestations
TL;DR: Developmental changes in prefrontal cortex and limbic brain regions of adolescents across a variety of species, alterations that include an apparent shift in the balance between mesocortical and mesolimbic dopamine systems likely contribute to the unique characteristics of adolescence.
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Behavioural despair in rats: a new model sensitive to antidepressant treatments.
TL;DR: Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.
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Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.
Deborah C. Rice,Stan Barone +1 more
TL;DR: Of critical concern is the possibility that developmental exposure to neurotoxicants may result in an acceleration of age-related decline in function, and the fact that developmental neurotoxicity that results in small effects can have a profound societal impact when amortized across the entire population and across the life span of humans.
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The use of a plus-maze to measure anxiety in the mouse
TL;DR: The plus-maze appears to be a useful test with which to investigate both anxiolytic and anxiogenic agents.
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The Mesolimbic Dopamine Reward Circuit in Depression
TL;DR: It is proposed that the NAc and VTA contribute importantly to the pathophysiology and symptomatology of depression and may even be involved in its etiology.
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