Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates.
Tiziana Rubino,Daniela Viganò,Natalia Realini,C. Guidali,Daniela Braida,Valeria Capurro,Chiara Castiglioni,Francesca Cherubino,Patrizia Romualdi,Sanzio Candeletti,Mariaelvina Sala,Daniela Parolaro +11 more
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TLDR
The results suggest that heavy cannabis consumption in adolescence may induce subtle alterations in the emotional circuit in female rats, ending in depressive-like behavior, whereas male rats show altered sensitivity to rewarding stimuli.About:
This article is published in Neuropsychopharmacology.The article was published on 2008-01-02 and is currently open access. It has received 317 citations till now. The article focuses on the topics: Ventral tegmental area & Nucleus accumbens.read more
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Journal ArticleDOI
Long-term hippocampal glutamate synapse and astrocyte dysfunctions underlying the altered phenotype induced by adolescent THC treatment in male rats.
Erica Zamberletti,Marina Gabaglio,Massimo Grilli,Pamela Prini,Alberto Catanese,Anna Pittaluga,Mario Marchi,Tiziana Rubino,Daniela Parolaro +8 more
TL;DR: The data suggest that the sex-dependent detrimental effects induced by adolescent THC exposure on adult behavior may rely on its ability to trigger different region-dependent changes in glutamate synapse and glial cells.
Journal ArticleDOI
Sex-specific disturbances of the glutamate/GABA balance in the hippocampus of adult rats subjected to adolescent cannabinoid exposure.
Alejandro Higuera-Matas,Miguel Miguéns,Santiago M. Coria,María Amparo Assis,Erika Borcel,Nuria Del Olmo,Emilio Ambrosio +6 more
TL;DR: It is shown that K(+)-induced γ-amino butyric acid (GABA) release increases in the CA1 hippocampal field of Wistar rats of both sexes that were treated chronically with the cannabinoid agonist CP 55,940 (CP55940) during adolescence, which disturbs the normal balance between glutamate and GABA transmission.
Journal ArticleDOI
Deconstructing the neurobiology of cannabis use disorder.
TL;DR: In this article, the authors discuss the neurobiological systems associated with cannabis use disorder, which often share common neural characteristics with other substance use disorders, that could inform prevention and treatment strategies.
Journal ArticleDOI
Sex-dependent long-term effects of adolescent exposure to THC and/or MDMA on neuroinflammation and serotoninergic and cannabinoid systems in rats.
Ana Belen Lopez-Rodriguez,Ana Belen Lopez-Rodriguez,Alvaro Llorente-Berzal,Luis M. Garcia-Segura,Maria-Paz Viveros +4 more
TL;DR: This study aimed to mimic human consumption patterns and investigated, in male and female animals, the long‐term effects of Δ9‐tetrahydrocannabinol (THC) and 3,4‐methylenedioxymethamphetamine (MDMA) on diverse neuro inflammation and neurotoxic markers.
Journal ArticleDOI
Pharmacokinetic, behavioral, and brain activity effects of Δ9-tetrahydrocannabinol in adolescent male and female rats.
Christina M. Ruiz,Alexa Torrens,Erik Castillo,Christina R Perrone,Jenny Cevallos,Victoria C. Inshishian,Eden V Harder,Drew N Justeson,Marilyn A. Huestis,Vivek Swarup,Daniele Piomelli,Stephen V. Mahler +11 more
TL;DR: A systematic investigation of THC pharmacokinetics, metabolism and distribution in blood and brain, and of THC effects upon behavior and neural activity in adolescent Long Evans rats of both sexes finds dose-dependent and sex-dependent effects on behavior, neural activity, and functional connectivity across multiple nodes of brain stress and reward networks.
References
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The adolescent brain and age-related behavioral manifestations
TL;DR: Developmental changes in prefrontal cortex and limbic brain regions of adolescents across a variety of species, alterations that include an apparent shift in the balance between mesocortical and mesolimbic dopamine systems likely contribute to the unique characteristics of adolescence.
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Behavioural despair in rats: a new model sensitive to antidepressant treatments.
TL;DR: Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.
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Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.
Deborah C. Rice,Stan Barone +1 more
TL;DR: Of critical concern is the possibility that developmental exposure to neurotoxicants may result in an acceleration of age-related decline in function, and the fact that developmental neurotoxicity that results in small effects can have a profound societal impact when amortized across the entire population and across the life span of humans.
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The use of a plus-maze to measure anxiety in the mouse
TL;DR: The plus-maze appears to be a useful test with which to investigate both anxiolytic and anxiogenic agents.
Journal ArticleDOI
The Mesolimbic Dopamine Reward Circuit in Depression
TL;DR: It is proposed that the NAc and VTA contribute importantly to the pathophysiology and symptomatology of depression and may even be involved in its etiology.
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