Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates.
Tiziana Rubino,Daniela Viganò,Natalia Realini,C. Guidali,Daniela Braida,Valeria Capurro,Chiara Castiglioni,Francesca Cherubino,Patrizia Romualdi,Sanzio Candeletti,Mariaelvina Sala,Daniela Parolaro +11 more
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The results suggest that heavy cannabis consumption in adolescence may induce subtle alterations in the emotional circuit in female rats, ending in depressive-like behavior, whereas male rats show altered sensitivity to rewarding stimuli.About:
This article is published in Neuropsychopharmacology.The article was published on 2008-01-02 and is currently open access. It has received 317 citations till now. The article focuses on the topics: Ventral tegmental area & Nucleus accumbens.read more
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Schizophrenia and Endocannabinoid Signaling in the Prefrontal Cortex
TL;DR: An adolescent cannabis abuse model induced by a specific agonist of the primary cannabinoid receptor (CB1R) in the brain shows permanent reduction in the eCB system signaling including impaired eCB-dependent synaptic plasticity and CB1R function, which suggests that the critical maladaptation underlying the etiology of psychosis may involve signaling mediated by presynaptic metabotropic receptors or downstream processes.
Book ChapterDOI
How adolescent cannabinoid exposure sets the stage for long-term emotional and cognitive dysregulation: Impacts on molecular and neuronal risk pathways
TL;DR: In this paper , the authors highlight several lines of pre-clinical evidence revealing how cannabinoid transmission in the mammalian brain can regulate emotional processing and cognition in specific mesocorticolimbic circuits and consider how these pathophysiological sequelae may set the stage for increased vulnerability to these disorders later in life.
Book ChapterDOI
Preclinical Models of THC and Nicotine Exposure During Adolescent Brain Development: Modeling Neuropsychiatric Phenotypes Related to Dopaminergic Transmission
References
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Journal ArticleDOI
The adolescent brain and age-related behavioral manifestations
TL;DR: Developmental changes in prefrontal cortex and limbic brain regions of adolescents across a variety of species, alterations that include an apparent shift in the balance between mesocortical and mesolimbic dopamine systems likely contribute to the unique characteristics of adolescence.
Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
TL;DR: Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.
Journal ArticleDOI
Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.
Deborah C. Rice,Stan Barone +1 more
TL;DR: Of critical concern is the possibility that developmental exposure to neurotoxicants may result in an acceleration of age-related decline in function, and the fact that developmental neurotoxicity that results in small effects can have a profound societal impact when amortized across the entire population and across the life span of humans.
Journal ArticleDOI
The use of a plus-maze to measure anxiety in the mouse
TL;DR: The plus-maze appears to be a useful test with which to investigate both anxiolytic and anxiogenic agents.
Journal ArticleDOI
The Mesolimbic Dopamine Reward Circuit in Depression
TL;DR: It is proposed that the NAc and VTA contribute importantly to the pathophysiology and symptomatology of depression and may even be involved in its etiology.
Related Papers (5)
Chronic pubertal, but not adult chronic cannabinoid treatment impairs sensorimotor gating, recognition memory, and the performance in a progressive ratio task in adult rats.
Miriam Schneider,Michael Koch +1 more