Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates.
Tiziana Rubino,Daniela Viganò,Natalia Realini,C. Guidali,Daniela Braida,Valeria Capurro,Chiara Castiglioni,Francesca Cherubino,Patrizia Romualdi,Sanzio Candeletti,Mariaelvina Sala,Daniela Parolaro +11 more
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TLDR
The results suggest that heavy cannabis consumption in adolescence may induce subtle alterations in the emotional circuit in female rats, ending in depressive-like behavior, whereas male rats show altered sensitivity to rewarding stimuli.About:
This article is published in Neuropsychopharmacology.The article was published on 2008-01-02 and is currently open access. It has received 317 citations till now. The article focuses on the topics: Ventral tegmental area & Nucleus accumbens.read more
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Long-term behavioral and pharmacodynamic effects of delta-9- tetrahydrocannabinol in female rats depend on ovarian hormone status
Peter J. Winsauer,Jill M. Daniel,Jill M. Daniel,Catalin M. Filipeanu,Stuart T. Leonard,Jerielle L. Hulst,Shaefali P. Rodgers,Caroline L. Lassen-Greene,Jessie L Sutton +8 more
TL;DR: Chronic administration of Δ9‐THC during adolescence in female rats produced long‐term effects on operant learning and performance tasks and on the cannabinoid system that were mediated by the presence of ovarian hormones, and that altered their sensitivity to Δ9-THC as adults.
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Cannabinoid effects on CB1 receptor density in the adolescent brain: An autoradiographic study using the synthetic cannabinoid HU210
TL;DR: The pattern of CB1 receptor downregulation was similar to that observed in adults treated with cannabinoids in previous studies; however, its magnitude was smaller in adolescents, which may contribute to some acute behavioral effects, the pharmacological cross‐tolerance and the long‐lasting, adverse psychological consequences of cannabinoid exposure during adolescence.
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Adolescent THC exposure in female rats leads to cognitive deficits through a mechanism involving chromatin modifications in the prefrontal cortex.
Pamela Prini,Franceso Rusconi,Erica Zamberletti,Marina Gabaglio,Federica Penna,Mauro Fasano,Elena Battaglioli,Daniela Parolaro,Tiziana Rubino +8 more
TL;DR: Through a mechanism involving SUV39H1, THC modifies histone modifications and, thereby, expression of plasticity genes, this pathway appears to be relevant for the development of cognitive deficits.
Journal ArticleDOI
Effects in rats of adolescent exposure to cannabis smoke or THC on emotional behavior and cognitive function in adulthood
Adriaan W. Bruijnzeel,Parker Knight,Stefany Panunzio,Song Xue,Matthew M. Bruner,Shannon C. Wall,Marjory Pompilus,Marcelo Febo,Barry Setlow +8 more
TL;DR: Neither cannabis smoke nor THC exposure during adolescence produced robust alterations in adult behavior after a period of abstinence, suggesting that adverse effects associated with adolescent cannabis use might be due to non-cannabinoid concomitants of cannabis use.
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Sex-specific tonic 2-arachidonoylglycerol signaling at inhibitory inputs onto dopamine neurons of Lister Hooded rats.
TL;DR: It is suggested that sex specific tonic 2-AG signaling might contribute to regulate responses to aversive intrinsic properties to cannabinoids, thus resulting in faster acquisition/initiation of cannabinoid taking and, eventually, in progression to addiction.
References
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The adolescent brain and age-related behavioral manifestations
TL;DR: Developmental changes in prefrontal cortex and limbic brain regions of adolescents across a variety of species, alterations that include an apparent shift in the balance between mesocortical and mesolimbic dopamine systems likely contribute to the unique characteristics of adolescence.
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Behavioural despair in rats: a new model sensitive to antidepressant treatments.
TL;DR: Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.
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Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.
Deborah C. Rice,Stan Barone +1 more
TL;DR: Of critical concern is the possibility that developmental exposure to neurotoxicants may result in an acceleration of age-related decline in function, and the fact that developmental neurotoxicity that results in small effects can have a profound societal impact when amortized across the entire population and across the life span of humans.
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The use of a plus-maze to measure anxiety in the mouse
TL;DR: The plus-maze appears to be a useful test with which to investigate both anxiolytic and anxiogenic agents.
Journal ArticleDOI
The Mesolimbic Dopamine Reward Circuit in Depression
TL;DR: It is proposed that the NAc and VTA contribute importantly to the pathophysiology and symptomatology of depression and may even be involved in its etiology.
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