Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates.
Tiziana Rubino,Daniela Viganò,Natalia Realini,C. Guidali,Daniela Braida,Valeria Capurro,Chiara Castiglioni,Francesca Cherubino,Patrizia Romualdi,Sanzio Candeletti,Mariaelvina Sala,Daniela Parolaro +11 more
TLDR
The results suggest that heavy cannabis consumption in adolescence may induce subtle alterations in the emotional circuit in female rats, ending in depressive-like behavior, whereas male rats show altered sensitivity to rewarding stimuli.About:
This article is published in Neuropsychopharmacology.The article was published on 2008-01-02 and is currently open access. It has received 317 citations till now. The article focuses on the topics: Ventral tegmental area & Nucleus accumbens.read more
Citations
More filters
Journal ArticleDOI
Long-term consequences of URB597 administration during adolescence on cannabinoid CB1 receptor binding in brain areas.
Eva M. Marco,Eva M. Marco,Tiziana Rubino,Walter Adriani,Maria-Paz Viveros,Daniela Parolaro,Giovanni Laviola +6 more
TL;DR: Present results provide evidence for long-lasting effects of adolescent URB597 administration, which may have implications for the maturational end-point of the endocannabinoid system itself, which could lead to permanent alterations in neuronal brain circuits and behavioural responses.
Journal ArticleDOI
Cannabinoid exposure in rat adolescence reprograms the initial behavioral, molecular, and epigenetic response to cocaine.
Maria Scherma,Johanna S. Qvist,Arun Asok,Shao-shan Carol Huang,Paolo Masia,Matteo Deidda,Ya B. Wei,Ya B. Wei,Rajesh Kumar Soni,Walter Fratta,Paola Fadda,Paola Fadda,Eric R. Kandel,Denise B. Kandel,Denise B. Kandel,Philippe A. Melas +15 more
TL;DR: It is demonstrated that a history of synthetic cannabinoid exposure in adolescent animals results in distinct molecular and epigenetic changes following initial exposure to cocaine, which are pronounced in the prefrontal cortex and associated with an enhanced response to cocaine’s stimulatory effects.
Journal ArticleDOI
Mifepristone attenuates depression-like changes induced by chronic central administration of interleukin-1β in rats.
Yongping Zhang,Hao-Yin Wang,Zhang Cai,Bai-Ping Liu,Zhilan Peng,Yu-Yu Li,Feng-Ming Liu,Cai Song +7 more
TL;DR: Test the hypothesis that glucocorticoid receptor (GR) antagonist mifepristone (RU486) may attenuate IL‐1&bgr;‐induced depression‐like behavior by regulating the neuroinflammation and neurotrophin functions of microglia and astrocytes and concludes that RU486 may improve depression-like changes by suppressing microgla and inflammation and promoting astroCytes to restore neurotrophic function.
Journal ArticleDOI
An animal model of female adolescent cannabinoid exposure elicits a long-lasting deficit in presynaptic long-term plasticity
TL;DR: It is suggested that adolescent cannabinoid exposure may permanently impair brain functions, including the brain's intrinsic ability to appropriately adapt to external influences.
Journal ArticleDOI
Preclinical Studies of Cannabinoid Reward, Treatments for Cannabis Use Disorder, and Addiction-Related Effects of Cannabinoid Exposure
TL;DR: Animal research provides an objective and controlled means of obtaining information about how cannabis affects the brain and behavior, whether medications can be developed to treat cannabis use disorder, and whether cannabis might produce lasting changes in the brain that increase the likelihood of becoming addicted to other drugs.
References
More filters
Journal ArticleDOI
The adolescent brain and age-related behavioral manifestations
TL;DR: Developmental changes in prefrontal cortex and limbic brain regions of adolescents across a variety of species, alterations that include an apparent shift in the balance between mesocortical and mesolimbic dopamine systems likely contribute to the unique characteristics of adolescence.
Journal ArticleDOI
Behavioural despair in rats: a new model sensitive to antidepressant treatments.
TL;DR: Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.
Journal ArticleDOI
Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.
Deborah C. Rice,Stan Barone +1 more
TL;DR: Of critical concern is the possibility that developmental exposure to neurotoxicants may result in an acceleration of age-related decline in function, and the fact that developmental neurotoxicity that results in small effects can have a profound societal impact when amortized across the entire population and across the life span of humans.
Journal ArticleDOI
The use of a plus-maze to measure anxiety in the mouse
TL;DR: The plus-maze appears to be a useful test with which to investigate both anxiolytic and anxiogenic agents.
Journal ArticleDOI
The Mesolimbic Dopamine Reward Circuit in Depression
TL;DR: It is proposed that the NAc and VTA contribute importantly to the pathophysiology and symptomatology of depression and may even be involved in its etiology.
Related Papers (5)
Chronic pubertal, but not adult chronic cannabinoid treatment impairs sensorimotor gating, recognition memory, and the performance in a progressive ratio task in adult rats.
Miriam Schneider,Michael Koch +1 more