Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates.
Tiziana Rubino,Daniela Viganò,Natalia Realini,C. Guidali,Daniela Braida,Valeria Capurro,Chiara Castiglioni,Francesca Cherubino,Patrizia Romualdi,Sanzio Candeletti,Mariaelvina Sala,Daniela Parolaro +11 more
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The results suggest that heavy cannabis consumption in adolescence may induce subtle alterations in the emotional circuit in female rats, ending in depressive-like behavior, whereas male rats show altered sensitivity to rewarding stimuli.About:
This article is published in Neuropsychopharmacology.The article was published on 2008-01-02 and is currently open access. It has received 317 citations till now. The article focuses on the topics: Ventral tegmental area & Nucleus accumbens.read more
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Assessing the Role of Cannabis Use on Cortical Surface Structure in Adolescents and Young Adults: Exploring Gender and Aerobic Fitness as Potential Moderators
TL;DR: It is demonstrated that aerobic fitness moderates the impact of cannabis on cortical surface structure, and gender differences are evident; these moderating factors may help explain inconsistencies in the literature and warrant further investigation.
Journal ArticleDOI
Endocannabinoid-Epigenetic Cross-Talk: A Bridge toward Stress Coping
TL;DR: This review highlights the protective role of 2-AG in stress-response termination and stress resiliency, and discusses ECS regulation with a further nuclear homeostatic system whose nature is exquisitely epigenetic, orchestrated by Lysine Specific Demethylase 1.
Journal ArticleDOI
Part III: Principal component analysis: bridging the gap between strain, sex and drug effects
TL;DR: It is demonstrated here that using PCA was able to describe the main variables of interest and demonstrate that THC exposure had a negligible effect on the variance in the data set, and that early life experience accounted for a large proportion of variance across data sets, although its relative contribution varied across tasks.
Book ChapterDOI
Endocannabinoid-serotonin systems interaction in health and disease.
TL;DR: In this article, the eCB/5-HT crosstalk at the neuronal and synaptic levels is explored for psychiatric and neurological disorders. But, the potential effect of 5-HT/eCB interaction at the behavioral level is not explored.
Book ChapterDOI
Gender Differences in Cannabis Addiction and Dependence
TL;DR: Clinical and laboratory-based research evidence revealing important sex-related differences in cannabinoid-induced effects on reward and motivation in males and females is reviewed.
References
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Journal ArticleDOI
The adolescent brain and age-related behavioral manifestations
TL;DR: Developmental changes in prefrontal cortex and limbic brain regions of adolescents across a variety of species, alterations that include an apparent shift in the balance between mesocortical and mesolimbic dopamine systems likely contribute to the unique characteristics of adolescence.
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Behavioural despair in rats: a new model sensitive to antidepressant treatments.
TL;DR: Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.
Journal ArticleDOI
Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.
Deborah C. Rice,Stan Barone +1 more
TL;DR: Of critical concern is the possibility that developmental exposure to neurotoxicants may result in an acceleration of age-related decline in function, and the fact that developmental neurotoxicity that results in small effects can have a profound societal impact when amortized across the entire population and across the life span of humans.
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The use of a plus-maze to measure anxiety in the mouse
TL;DR: The plus-maze appears to be a useful test with which to investigate both anxiolytic and anxiogenic agents.
Journal ArticleDOI
The Mesolimbic Dopamine Reward Circuit in Depression
TL;DR: It is proposed that the NAc and VTA contribute importantly to the pathophysiology and symptomatology of depression and may even be involved in its etiology.
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Chronic pubertal, but not adult chronic cannabinoid treatment impairs sensorimotor gating, recognition memory, and the performance in a progressive ratio task in adult rats.
Miriam Schneider,Michael Koch +1 more