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Open AccessJournal ArticleDOI

Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates.

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TLDR
The results suggest that heavy cannabis consumption in adolescence may induce subtle alterations in the emotional circuit in female rats, ending in depressive-like behavior, whereas male rats show altered sensitivity to rewarding stimuli.
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This article is published in Neuropsychopharmacology.The article was published on 2008-01-02 and is currently open access. It has received 317 citations till now. The article focuses on the topics: Ventral tegmental area & Nucleus accumbens.

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Book ChapterDOI

Novel insights into depression and antidepressants: a synergy between synaptogenesis and neurogenesis?

TL;DR: The ways by which improving both neurogenesis and synaptogenesis may enable effective recovery by acting on a larger neuronal network are described.
Journal ArticleDOI

Glycyrrhizic acid ameliorates the kynurenine pathway in association with its antidepressant effect.

TL;DR: It is demonstrated that GZA may restrain HMGB1 thus improving chronic stress‐induced depressive behavior through regulating KP, and the potential mechanism underlying GZA ameliorating chronic Stress‐induced depression both in vivo and in vitro.
Journal ArticleDOI

Sex-dependent psychoneuroendocrine effects of THC and MDMA in an animal model of adolescent drug consumption.

TL;DR: The results presented indicate that adolescent exposure to THC and/or MDMA induces long-term, sex-dependent psychophysiological alterations and they reveal functional interactions between the two drugs.
Journal ArticleDOI

Sex, THC, and hormones: Effects on density and sensitivity of CB1 cannabinoid receptors in rats.

TL;DR: Sex differences in the density and G-protein coupling of brain CB1 receptors may play a limited role in sex differences in acute THC effects not mediated by the hippocampus, consistent with a finding that women tend to progress to tolerance and dependence quicker than men after initiation of cannabis use.
Journal ArticleDOI

Brain activation to negative stimuli mediates a relationship between adolescent marijuana use and later emotional functioning.

TL;DR: Brain activity mediated the effect of marijuana use on later emotional functioning and resilience increased in controls but not heavy marijuana users across time points.
References
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Journal ArticleDOI

The adolescent brain and age-related behavioral manifestations

TL;DR: Developmental changes in prefrontal cortex and limbic brain regions of adolescents across a variety of species, alterations that include an apparent shift in the balance between mesocortical and mesolimbic dopamine systems likely contribute to the unique characteristics of adolescence.
Journal ArticleDOI

Behavioural despair in rats: a new model sensitive to antidepressant treatments.

TL;DR: Positive findings with atypical antidepressant drugs such as iprindole and mianserin suggest that the method may be capable of discovering new antidepressants hitherto undetectable with classical pharmacological tests.
Journal ArticleDOI

Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.

TL;DR: Of critical concern is the possibility that developmental exposure to neurotoxicants may result in an acceleration of age-related decline in function, and the fact that developmental neurotoxicity that results in small effects can have a profound societal impact when amortized across the entire population and across the life span of humans.
Journal ArticleDOI

The use of a plus-maze to measure anxiety in the mouse

TL;DR: The plus-maze appears to be a useful test with which to investigate both anxiolytic and anxiogenic agents.
Journal ArticleDOI

The Mesolimbic Dopamine Reward Circuit in Depression

TL;DR: It is proposed that the NAc and VTA contribute importantly to the pathophysiology and symptomatology of depression and may even be involved in its etiology.
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