Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates.
Tiziana Rubino,Daniela Viganò,Natalia Realini,C. Guidali,Daniela Braida,Valeria Capurro,Chiara Castiglioni,Francesca Cherubino,Patrizia Romualdi,Sanzio Candeletti,Mariaelvina Sala,Daniela Parolaro +11 more
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TLDR
The results suggest that heavy cannabis consumption in adolescence may induce subtle alterations in the emotional circuit in female rats, ending in depressive-like behavior, whereas male rats show altered sensitivity to rewarding stimuli.About:
This article is published in Neuropsychopharmacology.The article was published on 2008-01-02 and is currently open access. It has received 317 citations till now. The article focuses on the topics: Ventral tegmental area & Nucleus accumbens.read more
Citations
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Antidepressant-Like Activity and Modulation of Brain Monoaminergic Transmission by Blockade of Anandamide Hydrolysis
Gabriella Gobbi,Francis Rodriguez Bambico,Regina A. Mangieri,Marco Bortolato,Patrizia Campolongo,Tommaso Cassano,Maria Grazia Morgese,Guy Debonnel,Andrea Duranti,A. Tontini,Giorgio Tarzia,Marco Mor,Viviana Trezza,Steven R. Goldberg,Vincenzo Cuomo,Daniele Piomelli +15 more
TL;DR: Gobi et al. as discussed by the authors showed that URB597, a selective inhibitor of the enzyme fatty acid amide hydrolase, which catalyzes the intracellular hydrolysis of the endocannabinoid anandamide, exerts potent antidepressant-like effects in the mouse tail-suspension test and the rat forced-swim test.
Journal ArticleDOI
From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology
TL;DR: This review article aims to describe and critically discuss the pharmacology and potential impact on mammalian physiology of all major phytocannabinoids, and not only of the most famous one Δ(9)-tetrahydrocannabinol, and the adaptive pro-homeostatic physiological, or maladaptive pathological, roles of the ECS in mammalian cells, tissues, and organs.
Journal ArticleDOI
Keep off the grass? Cannabis, cognition and addiction
H. Valerie Curran,Tom P. Freeman,Claire Mokrysz,David A. Lewis,Celia J. A. Morgan,Celia J. A. Morgan,Loren H. Parsons +6 more
TL;DR: The current state of knowledge about vulnerability factors, the variations in types of cannabis, and the relationship between these and cognition and addiction are reviewed.
Journal ArticleDOI
Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study.
Alexander Neumeister,Marc D. Normandin,Marc D. Normandin,Robert H. Pietrzak,Robert H. Pietrzak,Daniele Piomelli,Ming-Qiang Zheng,Ana Gujarro-Anton,Marc N. Potenza,Christopher R. Bailey,Shu-fei Lin,Soheila Najafzadeh,Jim Ropchan,Shannan Henry,Stefani Corsi-Travali,Richard E. Carson,Yiyun Huang +16 more
TL;DR: It is suggested that abnormal CB1 receptor-mediated anandamide signaling is implicated in the etiology of PTSD, and provide a promising neurobiological model to develop novel, evidence-based pharmacotherapies for this disorder.
Journal ArticleDOI
Effects of Cannabis on Neurocognitive Functioning: Recent Advances, Neurodevelopmental Influences, and Sex Differences
TL;DR: The purpose of this review was to provide an update on research of cannabis’ acute and non-acute effects on neurocognition, with a focus on findings since 2007, and suggest and discuss how neurodevelopmental issues and sex differences may influence cannabis effects on neuroscience.
References
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Trajectories of brain development: point of vulnerability or window of opportunity?
TL;DR: This review endeavors to provide an overview of key components of mammalian brain development while simultaneously providing a framework for how perturbations during these changes uniquely impinge on the final outcome.
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Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study
Louise Arseneault,Mary Cannon,Richie Poulton,Robin M. Murray,Avshalom Caspi,Terrie E. Moffitt +5 more
TL;DR: This is the first prospective longitudinal study of adolescent cannabis use as a risk factor for adult schizophreniform disorder, taking into account childhood psychotic symptoms, and the Dunedin multidisciplinary health and development study has a 96% follow up rate at age 26.
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The many faces of CREB
TL;DR: Emerging evidence suggests that strategies that exploit regional differences in upstream factors or that target specific CREB-regulated genes, rather than CREB itself, could make a promising contribution to the treatment of neuropsychiatric conditions.
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Chronic antidepressant administration increases the expression of camp response element binding protein (creb) in rat hippocampus
TL;DR: Findings indicate that upregulation of CREB is a common action of chronic antidepressant treatments that may lead to regulation of specific target genes, such as BDNF and trkB, and to the long-term effects of these treatments on brain function.
Journal ArticleDOI
Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis
Gabriella Gobbi,Francis Rodriguez Bambico,Regina A. Mangieri,Marco Bortolato,Patrizia Campolongo,Marcello Solinas,Tommaso Cassano,Maria Grazia Morgese,Guy Debonnel,Andrea Duranti,Andrea Tontini,Giorgio Tarzia,Marco Mor,Viviana Trezza,Steven R. Goldberg,Vincenzo Cuomo,Daniele Piomelli +16 more
TL;DR: It is shown that URB597, a selective inhibitor of the enzyme fatty-acid amide hydrolase, which catalyzes the intracellular hydrolysis of the endocannabinoid anandamide, exerts potent antidepressant-like effects in the mouse tail-suspension test and the rat forced-swim test.
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