Circular RNAs function as ceRNAs to regulate and control human cancer progression.
Yaxian Zhong,Yaxian Zhong,Yajun Du,Yajun Du,Xue Yang,Xue Yang,Yongzhen Mo,Yongzhen Mo,Chunmei Fan,Fang Xiong,Daixi Ren,Daixi Ren,Xin Ye,Xin Ye,Chunwei Li,Chunwei Li,Yumin Wang,Yumin Wang,Fang Wei,Can Guo,Xu Wu,Xiaoling Li,Xiaoling Li,Yong Li,Yong Li,Guiyuan Li,Guiyuan Li,Zhaoyang Zeng,Zhaoyang Zeng,Wei Xiong,Wei Xiong +30 more
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TLDR
The progress in studying the role of circRNAs as ceRNAs in tumors is reviewed and the participation of circ RNAs in signal transduction pathways to regulate cellular functions is highlighted.Abstract:
Circular RNAs (circRNAs) are connected at the 3′ and 5′ ends by exon or intron cyclization, forming a complete ring structure. circRNA is more stable and conservative than linear RNA and abounds in various organisms. In recent years, increasing numbers of reports have found that circRNA plays a major role in the biological functions of a network of competing endogenous RNA (ceRNA). circRNAs can compete together with microRNAs (miRNAs) to influence the stability of target RNAs or their translation, thus, regulating gene expression at the transcriptional level. circRNAs are involved in biological processes such as tumor cell proliferation, apoptosis, invasion, and migration as ceRNAs. circRNAs, therefore, represent promising candidates for clinical diagnosis and treatment. Here, we review the progress in studying the role of circRNAs as ceRNAs in tumors and highlight the participation of circRNAs in signal transduction pathways to regulate cellular functions.read more
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Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape.
Xianjie Jiang,Xianjie Jiang,Jie Wang,Xiangying Deng,Fang Xiong,Junshang Ge,Junshang Ge,Bo Xiang,Bo Xiang,Xu Wu,Xu Wu,Jian Ma,Jian Ma,Ming Zhou,Ming Zhou,Xiaoling Li,Xiaoling Li,Yong Li,Yong Li,Guiyuan Li,Guiyuan Li,Wei Xiong,Wei Xiong,Can Guo,Can Guo,Zhaoyang Zeng,Zhaoyang Zeng +26 more
TL;DR: Overall, the evidence accumulated to date suggests that induction of PD-L1 by inflammatory factors in the tumor microenvironment may be one of the most important factors affecting the therapeutic efficiency of PD -L1/PD-1 blocking.
Journal ArticleDOI
Functions of N6-methyladenosine and its role in cancer.
TL;DR: Al Alteration of m6A levels participates in cancer pathogenesis and development via regulating expression of tumor-related genes like BRD4, MYC, SOCS2 and EGFR and corresponding potential targets in cancer therapy are reviewed.
Journal ArticleDOI
Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway
Xing Zhang,Sen Wang,Haixiao Wang,Jiacheng Cao,Xiaoxu Huang,Zheng Chen,Penghui Xu,Guangli Sun,Jianghao Xu,Jialun Lv,Zekuan Xu +10 more
TL;DR: It is proved that circNRIP1 sponges miR-149-5p to affect the expression level of AKT1 and eventually acts as a tumour promotor in GC and demonstrated that quaking can promote circ NRIP1 transcription.
Journal ArticleDOI
Circular RNAs: Promising Biomarkers for Human Diseases.
TL;DR: The current understanding of biogenesis and gene regulatory mechanisms of circRNAs is provided, the recent studies oncircRNAs as potential diagnostic and prognostic biomarkers are summarized, and the major advantages and limitations of circ RNAs as novel biomarkers based on existing knowledge are highlighted.
Journal ArticleDOI
Circular RNA-protein interactions: functions, mechanisms, and identification.
TL;DR: The current knowledge regarding circRNA-protein interactions and the methods used to identify and characterize these interactions are reviewed and new insights are summarized into the potential mechanisms underlying these interactions.
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Journal ArticleDOI
A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
TL;DR: It is proposed that this "competing endogenous RNA" (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer.