Endocytosis of gene delivery vectors: from clathrin-dependent to lipid raft-mediated endocytosis.
TLDR
This review covers the well-recognized clathrin-mediated endocytosis (CME), phagocytotic, and macropinocyTosis in addition to the less addressed pathways that take place in lipid rafts, and summarizes the regulators associated with each uptake pathway.About:
This article is published in Molecular Therapy.The article was published on 2013-06-01 and is currently open access. It has received 247 citations till now. The article focuses on the topics: Endocytic vesicle & Endocytic cycle.read more
Citations
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Journal ArticleDOI
Internalized Amyloid-β (1-42) Peptide Inhibits the Store-Operated Calcium Entry in HT-22 Cells
Joana Poejo,Yolanda Orantos-Aguilera,Francisco Javier Martin-Romero,Ana M. Mata,Carlos Gutiérrez-Merino +4 more
TL;DR: It is concluded that Aβ(1-42)-induced SOCE dysregulation in HT-22 cells is caused by the inhibitory modulation of STIM1, and the partial activation of ER Ca2+-leak channels.
Cellular Dyes and Bioactive Peptides - Cell Membrane Interactions and Cellular Uptake
TL;DR: In this thesis, the cellular uptake of cell-penetrating peptides, interesting as drug delivery systems and of the antisecretory peptide, AF-16, is examined and ruthenium dipyridophenazine complexes have tunable affinity for biomembranes and nucleic acids upon slight changes of their lipophilicity and stereochemistry.
Journal ArticleDOI
Biotherapeutic effect of cell-penetrating peptides against microbial agents: a review.
TL;DR: In this article, a review of cell-penetrating peptides (CPPs) used to treat microbial infections is presented, showing that although these peptides are biologically active for infections, effective transduction into membranes and cargo transport, serum stability, and half-life must be improved for optimum functions and development of next generation antimicrobial agents.
Dissertation
Equine CD172a+ monocytic cells, the 'Trojan horse' for equine herpesvirus type 1 (EHV-1) dissemination in the horse
TL;DR: It is hypothesized that EHV-1 delays its replication in monocytic cells in order to avoid recognition by the immune system and is part of an immune evasive strategy and involves silencing of EHv-1 gene expression associated with histone deacetylases.
Journal ArticleDOI
The J-domain of heat shock protein 40 can enhance the transduction efficiency of arginine-rich cell-penetrating peptides.
TL;DR: The route of the cellular membrane translocation of these recombinant proteins is suggested via macropinocytosis followed by an endosomal escape pathway.
References
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Journal ArticleDOI
Functional rafts in cell membranes
Kai Simons,Elina Ikonen +1 more
TL;DR: A new aspect of cell membrane structure is presented, based on the dynamic clustering of sphingolipids and cholesterol to form rafts that move within the fluid bilayer that function as platforms for the attachment of proteins when membranes are moved around inside the cell and during signal transduction.
Journal ArticleDOI
The fluid mosaic model of the structure of cell membranes.
S. J. Singer,Garth L. Nicolson +1 more
TL;DR: Results strongly indicate that the bivalent antibodies produce an aggregation of the surface immunoglobulin molecules in the plane of the membrane, which can occur only if the immunoglOBulin molecules are free to diffuse in the membrane.
Journal ArticleDOI
Regulated portals of entry into the cell
Sean D. Conner,Sandra L. Schmid +1 more
TL;DR: ‘Endocytosis’ encompasses several diverse mechanisms by which cells internalize macromolecules and particles into transport vesicles derived from the plasma membrane and must be viewed in a broader context than simple vesicular trafficking.
Journal ArticleDOI
Mechanisms of Endocytosis
TL;DR: What is known about mammalian endocytic mechanisms is reviewed, with focus on the cellular proteins that control these events, and the functional relevance of distinctendocytic pathways is discussed.
Book ChapterDOI
THE FLUID MOSAIC MODEL OF THE STRUCTURE OF CELL MEMBRANES Reprinted with permission from Science, Copyright AAA, 18 February 1972, Volume 175, pp. 720–731.
S. J. Singer,Garth L. Nicolson +1 more
TL;DR: Results strongly indicate that the bivalent antibodies produce an aggregation of the surface immunoglobulin molecules in the plane of the membrane, which can occur only if the immunoglOBulin molecules are free to diffuse in the membrane.