Endocytosis of gene delivery vectors: from clathrin-dependent to lipid raft-mediated endocytosis.
TLDR
This review covers the well-recognized clathrin-mediated endocytosis (CME), phagocytotic, and macropinocyTosis in addition to the less addressed pathways that take place in lipid rafts, and summarizes the regulators associated with each uptake pathway.About:
This article is published in Molecular Therapy.The article was published on 2013-06-01 and is currently open access. It has received 247 citations till now. The article focuses on the topics: Endocytic vesicle & Endocytic cycle.read more
Citations
More filters
Journal ArticleDOI
Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases
TL;DR: The proteolytic processing, intracellular trafficking and nuclear functions of RTKs are summarized, and how they promote cancer progression, and their clinical implications are discussed.
Journal ArticleDOI
A mosquito salivary protein promotes flavivirus transmission by activation of autophagy.
Peng Sun,Kaixiao Nie,Yibin Zhu,Yibin Zhu,Yang Liu,Pa Wu,Ziwen Liu,Senyan Du,Huahao Fan,Chun-Hong Chen,Renli Zhang,Penghua Wang,Gong Cheng,Gong Cheng +13 more
TL;DR: The authors show that Aedes aegypti venom allergen-1 ( Aa VA-1) promotes dengue and Zika virus transmission by activating autophagy in host immune cells of the monocyte lineage.
Journal ArticleDOI
Fluorescent Carbon Dots for Selective Labeling of Subcellular Organelles
Binesh Unnikrishnan,Ren-Siang Wu,Shih-Chun Wei,Chih-Ching Huang,Chih-Ching Huang,Huan-Tsung Chang,Huan-Tsung Chang +6 more
TL;DR: This review discusses the applications of fluorescent CDs for the labeling of organelles, including lysosome, nucleoli, nucleus, endoplasmic reticulum, and mitochondria and highlights the importance of the surface properties (functional groups, hydrophobicity/hydrophilicity, charges, zwitterions) and the size of CDs for labeling.
Journal ArticleDOI
Cell-penetrating Peptides: Efficient Vectors for Vaccine Delivery.
TL;DR: This review describes the different mechanisms of CPP intercellular uptake and various CPP-based vaccine delivery strategies.
Journal ArticleDOI
DJ-1 deficiency impairs glutamate uptake into astrocytes via the regulation of flotillin-1 and caveolin-1 expression.
TL;DR: It is observed that DJ-1 deficiency decreased the expression of flotillin-1 (flot-1) and caveolin- 1 (cav-1), the main protein components of lipid rafts, in primary astrocytes and MEF cells.
References
More filters
Journal ArticleDOI
Functional rafts in cell membranes
Kai Simons,Elina Ikonen +1 more
TL;DR: A new aspect of cell membrane structure is presented, based on the dynamic clustering of sphingolipids and cholesterol to form rafts that move within the fluid bilayer that function as platforms for the attachment of proteins when membranes are moved around inside the cell and during signal transduction.
Journal ArticleDOI
The fluid mosaic model of the structure of cell membranes.
S. J. Singer,Garth L. Nicolson +1 more
TL;DR: Results strongly indicate that the bivalent antibodies produce an aggregation of the surface immunoglobulin molecules in the plane of the membrane, which can occur only if the immunoglOBulin molecules are free to diffuse in the membrane.
Journal ArticleDOI
Regulated portals of entry into the cell
Sean D. Conner,Sandra L. Schmid +1 more
TL;DR: ‘Endocytosis’ encompasses several diverse mechanisms by which cells internalize macromolecules and particles into transport vesicles derived from the plasma membrane and must be viewed in a broader context than simple vesicular trafficking.
Journal ArticleDOI
Mechanisms of Endocytosis
TL;DR: What is known about mammalian endocytic mechanisms is reviewed, with focus on the cellular proteins that control these events, and the functional relevance of distinctendocytic pathways is discussed.
Book ChapterDOI
THE FLUID MOSAIC MODEL OF THE STRUCTURE OF CELL MEMBRANES Reprinted with permission from Science, Copyright AAA, 18 February 1972, Volume 175, pp. 720–731.
S. J. Singer,Garth L. Nicolson +1 more
TL;DR: Results strongly indicate that the bivalent antibodies produce an aggregation of the surface immunoglobulin molecules in the plane of the membrane, which can occur only if the immunoglOBulin molecules are free to diffuse in the membrane.