Endocytosis of gene delivery vectors: from clathrin-dependent to lipid raft-mediated endocytosis.
TLDR
This review covers the well-recognized clathrin-mediated endocytosis (CME), phagocytotic, and macropinocyTosis in addition to the less addressed pathways that take place in lipid rafts, and summarizes the regulators associated with each uptake pathway.About:
This article is published in Molecular Therapy.The article was published on 2013-06-01 and is currently open access. It has received 247 citations till now. The article focuses on the topics: Endocytic vesicle & Endocytic cycle.read more
Citations
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Journal ArticleDOI
The Effect of Surface Charges on the Cellular Uptake of Liposomes Investigated by Live Cell Imaging
TL;DR: This study provides a better understanding on the cellular uptake mechanisms of the liposomes, which could contribute significantly to development of liposome-based drug delivery systems.
Journal ArticleDOI
Clathrin to Lipid Raft-Endocytosis via Controlled Surface Chemistry and Efficient Perinuclear Targeting of Nanoparticle
Atanu Chakraborty,Nikhil R. Jana +1 more
TL;DR: It is shown that nanoparticle surface chemistry can be tuned to alter their cell uptake mechanism and subcellular trafficking, and the zwitterionic-lipophilic nanoprobe has the unique advantage as it weakly interacts with anionic cell membrane, migrates toward lipid rafts for interaction through lipophilic functional group, and induces lipid raft-mediated endocytosis.
Journal ArticleDOI
Endocytosis of tight junction proteins and the regulation of degradation and recycling
Svetlana M. Stamatovic,Allison M. Johnson,Nikola Sladojevic,Richard F. Keep,Anuska V. Andjelkovic +4 more
TL;DR: A greater understanding of endocytosis and vesicular trafficking of TJ proteins in both epithelial and endothelial cells may allow for the development of methods to modulate barrier permeability for drug delivery or prevent barrier dysfunction in disease states.
Journal ArticleDOI
Poly(ethylene glycol)-block-cationic polylactide nanocomplexes of differing charge density for gene delivery
Chih-Kuang Chen,Charles H. Jones,Panagiotis Mistriotis,Yun Yu,Xiaoni Ma,Anitha Ravikrishnan,Ming Jiang,Stelios T. Andreadis,Blaine A. Pfeifer,Chong Cheng +9 more
TL;DR: Results help to elucidate the influence of charge, size, and PEGylation of nanocomplexes upon the delivery of nucleic acids in physiologically relevant conditions.
Journal ArticleDOI
Sustained delivery of proangiogenic microRNA-132 by nanoparticle transfection improves endothelial cell transplantation
Julie Devalliere,William G. Chang,Jillian W. Andrejecsk,Parwiz Abrahimi,Christopher J. Cheng,Dan Jane-wit,W. Mark Saltzman,Jordan S. Pober +7 more
TL;DR: Sustained delivery of proangiogenic microRNA‐132 encapsulated in a targeted biodegradable polymer NP is a safe and efficient strategy to improve EC transplantation and vascularization.
References
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Journal ArticleDOI
Functional rafts in cell membranes
Kai Simons,Elina Ikonen +1 more
TL;DR: A new aspect of cell membrane structure is presented, based on the dynamic clustering of sphingolipids and cholesterol to form rafts that move within the fluid bilayer that function as platforms for the attachment of proteins when membranes are moved around inside the cell and during signal transduction.
Journal ArticleDOI
The fluid mosaic model of the structure of cell membranes.
S. J. Singer,Garth L. Nicolson +1 more
TL;DR: Results strongly indicate that the bivalent antibodies produce an aggregation of the surface immunoglobulin molecules in the plane of the membrane, which can occur only if the immunoglOBulin molecules are free to diffuse in the membrane.
Journal ArticleDOI
Regulated portals of entry into the cell
Sean D. Conner,Sandra L. Schmid +1 more
TL;DR: ‘Endocytosis’ encompasses several diverse mechanisms by which cells internalize macromolecules and particles into transport vesicles derived from the plasma membrane and must be viewed in a broader context than simple vesicular trafficking.
Journal ArticleDOI
Mechanisms of Endocytosis
TL;DR: What is known about mammalian endocytic mechanisms is reviewed, with focus on the cellular proteins that control these events, and the functional relevance of distinctendocytic pathways is discussed.
Book ChapterDOI
THE FLUID MOSAIC MODEL OF THE STRUCTURE OF CELL MEMBRANES Reprinted with permission from Science, Copyright AAA, 18 February 1972, Volume 175, pp. 720–731.
S. J. Singer,Garth L. Nicolson +1 more
TL;DR: Results strongly indicate that the bivalent antibodies produce an aggregation of the surface immunoglobulin molecules in the plane of the membrane, which can occur only if the immunoglOBulin molecules are free to diffuse in the membrane.