Endothelial cell senescence in aging-related vascular dysfunction.
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TLDR
A contemporary update on molecular mechanisms, pathophysiological events, as well functional changes in EC senescence and age-associated cardiovascular disease is provided.Citations
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NLRP3 inflammasome in endothelial dysfunction.
Baochen Bai,Yanyan Yang,Qi Wang,Min Li,Chao Tian,Yan Liu,Lynn Htet Htet Aung,Peifeng Li,Tao Yu,Xian-ming Chu +9 more
TL;DR: A comprehensive perspective on the pivotal role of NLR-family pyrin domain-containing protein 3 (NLRP3) inflammasome activation in aggravating oxidative stress and endothelial dysfunction and the possible underlying mechanisms is provided.
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An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
Nazish Sayed,Yingxiang Huang,Khiem Van Nguyen,Zuzana Krejciova-Rajaniemi,Anissa P. Grawe,Tianxiang Gao,Robert Tibshirani,Trevor Hastie,Ayelet Alpert,Lu Cui,Tatiana Kuznetsova,Yael Rosenberg-Hasson,Rita Ostan,Daniela Monti,Benoit Lehallier,Shai S. Shen-Orr,Holden T. Maecker,Cornelia L. Dekker,Tony Wyss-Coray,Claudio Franceschi,Vladimir Jojic,Francois Haddad,Jose G. Montoya,Joseph C. Wu,Mark M. Davis,David Furman +25 more
TL;DR: A key role is identified in age-related chronic inflammation of CXCL9 in cardiac aging, adverse cardiac remodeling and poor vascular function and a metric for multimorbidity is derived that can be utilized for the early detection of age- related clinical phenotypes.
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Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes.
Massimiliano Bonafè,Francesco Prattichizzo,Angelica Giuliani,Gianluca Storci,Jacopo Sabbatinelli,Fabiola Olivieri +5 more
TL;DR: The hypothesis that four well-recognized features of aging contribute to the disproportionate SARS-CoV-2 mortality suffered by elderly men is advanced, suggesting that clarification of the mechanisms of inflamm-aging and immune senescence can help combat not only age-related disorders but also Sars-Cov-2 infection.
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The quiescent endothelium: signalling pathways regulating organ-specific endothelial normalcy.
TL;DR: Signalling pathways involved in the maintenance of functionally quiescent endothelia are starting to be identified and are a combination of endocrine, autocrine, paracrine and mechanical inputs.
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Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19.
Felice D’Agnillo,Kathie-Anne Walters,Yongli Xiao,Zong-Mei Sheng,Kelsey Scherler,Jae-Keun Park,Sebastian Gygli,Luz Angela Rosas,Kaitlyn Sadtler,Heather Kalish,Charles Blatti,Ruoqing Zhu,Lisa Gatzke,Colleen Bushell,Matthew J. Memoli,Steven J. O'Day,Trevan D Fischer,Terese C. Hammond,Raymond Lee,J. Christian Cash,Matthew E Powers,Grant E. O'Keefe,Kelly J. Butnor,Amy Rapkiewicz,William D. Travis,Scott P Layne,John C. Kash,Jeffery K. Taubenberger +27 more
References
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DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
TL;DR: It is demonstrated that two recently identified DNA methyltransferases, DnMT3a and Dnmt3b, are essential for de novo methylation and for mouse development and play important roles in normal development and disease.
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Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
Anne Brunet,Lora B. Sweeney,J. Fitzhugh Sturgill,Katrin F. Chua,Paul L. Greer,Yingxi Lin,Hien Tran,Sarah E. Ross,Raul Mostoslavsky,Haim Y. Cohen,Linda Hu,Hwei-Ling Cheng,Mark P. Jedrychowski,Steven P. Gygi,David A. Sinclair,Frederick W. Alt,Michael E. Greenberg +16 more
TL;DR: One way in which members of the Sir2 family of proteins may increase organismal longevity is by tipping FOXO-dependent responses away from apoptosis and toward stress resistance.
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Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
TL;DR: The session on inflammation of the Advances in Gerosciences meeting held at the National Institutes of Health/National Institute on Aging in Bethesda on October 30 and 31, 2013 was aimed at defining these important unanswered questions about inflammaging.
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Arterial Stiffness and Cardiovascular Events The Framingham Heart Study
Gary F. Mitchell,Shih-Jen Hwang,Ramachandran S. Vasan,Martin G. Larson,Michael J. Pencina,Naomi M. Hamburg,Joseph A. Vita,Daniel Levy,Emelia J. Benjamin +8 more
TL;DR: Higher aortic stiffness assessed by PWV is associated with increased risk for a first cardiovascular event and improves risk prediction when added to standard risk factors and may represent a valuable biomarker of cardiovascular disease risk in the community.
Journal ArticleDOI
Suppression of Aging in Mice by the Hormone Klotho
Hiroshi Kurosu,Masaya Yamamoto,Jeremy D. Clark,Johanne Pastor,Animesh Nandi,Prem Gurnani,Owen P. McGuinness,Hirotaka Chikuda,Masayuki Yamaguchi,Hiroshi Kawaguchi,Iichiro Shimomura,Yoshiharu Takayama,Joachim Herz,C. Ronald Kahn,Kevin P. Rosenblatt,Makoto Kuro-o +15 more
TL;DR: It is shown that overexpression of Klotho in mice extends life span and it is suggested that Klotha-mediated inhibition of insulin and IGF1 signaling contributes to its anti-aging properties.
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