Engineering precision nanoparticles for drug delivery
Michael J. Mitchell,Margaret M. Billingsley,Rebecca M Haley,Marissa E. Wechsler,Nicholas A. Peppas,Robert Langer +5 more
Reads0
Chats0
TLDR
Advances in nanoparticle design that overcome heterogeneous barriers to delivery are discussed, arguing that intelligent nanoparticles design can improve efficacy in general delivery applications while enabling tailored designs for precision applications, thereby ultimately improving patient outcome overall.Abstract:
In recent years, the development of nanoparticles has expanded into a broad range of clinical applications. Nanoparticles have been developed to overcome the limitations of free therapeutics and navigate biological barriers - systemic, microenvironmental and cellular - that are heterogeneous across patient populations and diseases. Overcoming this patient heterogeneity has also been accomplished through precision therapeutics, in which personalized interventions have enhanced therapeutic efficacy. However, nanoparticle development continues to focus on optimizing delivery platforms with a one-size-fits-all solution. As lipid-based, polymeric and inorganic nanoparticles are engineered in increasingly specified ways, they can begin to be optimized for drug delivery in a more personalized manner, entering the era of precision medicine. In this Review, we discuss advanced nanoparticle designs utilized in both non-personalized and precision applications that could be applied to improve precision therapies. We focus on advances in nanoparticle design that overcome heterogeneous barriers to delivery, arguing that intelligent nanoparticle design can improve efficacy in general delivery applications while enabling tailored designs for precision applications, thereby ultimately improving patient outcome overall.read more
Citations
More filters
Journal ArticleDOI
Lipid Nanoparticles-From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement.
TL;DR: Liposomes, an early version of LNPs, are a versatile nanomedicine delivery platform for treatment of a variety of diseases, such as antitumor and nucleic acid therapeutics and vaccine delivery systems as mentioned in this paper.
Journal Article
T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity
Daniela Schmid,Chun Gwon Park,Christina A. Hartl,Nikita Subedi,Adam N.R. Cartwright,Regina Bou Puerto,James Maiarana,Gordon J. Freeman,Kai W. Wucherpfennig,Michael S. Goldberg,Yiran Zheng,Darrell J. Irvine +11 more
TL;DR: PD-1-targeting nanoparticles containing a TGFβ inhibitor or a TLR7/8 agonist are used to deliver these payloads to T cells or via T cells to the tumor microenvironment, leading to anti-tumor efficacy in vivo.
64Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer
Helen Lee,Anthony F. Shields,Barry A. Siegal,Kathy D. Miller,Ian E. Krop,Cynthia X. Ma,Patricia LoRusso,Pamela N. Munster,Karen Campbell,Daniel F. Gaddy,Shannon C. Leonard,Elena Geretti,Stephanie J. Blocker,Dmitri B. Kirpotin,Victor Moyo,Thomas Wickham,Bart S. Hendriks +16 more
TL;DR: Findings provide important evidence and quantification of the EPR effect in human metastatic tumors and support imaging nanoparticle deposition in tumors as a potential means to identify patients well suited for treatment with therapeutic nanoparticles.
Journal ArticleDOI
Role of nanotechnology behind the success of mRNA vaccines for COVID-19.
Amit Khurana,Prince Allawadhi,Isha Khurana,Sachin Allwadhi,Ralf Weiskirchen,Anil Kumar Banothu,Deepak Chhabra,Kamaldeep Joshi,Kala Kumar Bharani +8 more
TL;DR: The emergency use authorization (EUA) by the US-FDA for two mRNA-based vaccines BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) has brought hope of addressing the COVID-19 pandemic which has killed more than two million people globally as mentioned in this paper.
Journal Article
Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems B
TL;DR: It is shown that LNP-siRNA systems can exhibit progressively more bilayer structure as the proportion of bilayer DSPC lipid is increased, suggesting that the core of LNPs can exhibit a continuum of nanostructures depending on the proportions and structural preferences of component lipids.
References
More filters
Journal ArticleDOI
Concomitant SK current activation and sodium current inhibition cause J wave syndrome.
Mu Chen,Mu Chen,Dongzhu Xu,Dongzhu Xu,Adonis Z Wu,Shuai Guo,Shuai Guo,Juyi Wan,Dechun Yin,Dechun Yin,Shien-Fong Lin,Zhenhui Chen,Michael Rubart-von der Lohe,Thomas H. Everett,Zhilin Qu,James N. Weiss,Peng Sheng Chen +16 more
TL;DR: It is shown that the concomitant activation of small-conductance calcium-activated potassium (SK) current (IKAS) and inhibition of sodium current by cyclohexyl-[2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-pyrimidin-4-yl]-amine (CyPPA) recapitulate the phenotypes of JWS in Langendorff-perfused rabbit hearts.
Journal ArticleDOI
Transport and delivery of interferon-α through epithelial tight junctions via pH-responsive poly(methacrylic acid-grafted-ethylene glycol) nanoparticles.
TL;DR: These studies demonstrate the capabilities of poly(methacrylic acid-grafted-ethylene glycol) hydrogel nanoparticles to contribute to the improved oral delivery of protein chemotherapeutics.
Journal ArticleDOI
Delivery of Nanoparticles across the Intestinal Epithelium via the Transferrin Transport Pathway.
TL;DR: It is strongly suggested that the Tf transport pathway should be considered as a candidate biological transport route for orally-administered nanomedicines and drugs with poor oral bioavailability.
Journal ArticleDOI
Glucose and H2O2 Dual-Responsive Polymeric Micelles for the Self-Regulated Release of Insulin
TL;DR: The glucose-responsive release of insulin was achieved and could be further facilitated by the coencapsulation of glucose oxidase (GOx) in the micelles, which would prod...
Journal ArticleDOI
Co-delivery of plantamajoside and sorafenib by a multi-functional nanoparticle to combat the drug resistance of hepatocellular carcinoma through reprograming the tumor hypoxic microenvironment.
TL;DR: Functionalization of the NP-PMS/SOR with CT peptides signally improved the accumulation of drugs at tumor sites and penetration of agents into tumor cells, which in turn resulted in stronger capacity of tumor growth inhibition.
Related Papers (5)
Nano based drug delivery systems: recent developments and future prospects
Jayanta Kumar Patra,Gitishree Das,Leonardo Fernandes Fraceto,Leonardo Fernandes Fraceto,Estefania Vangelie Ramos Campos,Estefania Vangelie Ramos Campos,Maria del Pilar Rodriguez-Torres,Laura Susana Acosta-Torres,Luis A. Diaz-Torres,Renato Grillo,Mallappa Kumara Swamy,Shivesh Sharma,Solomon Habtemariam,Han-Seung Shin +13 more