Engineering precision nanoparticles for drug delivery
Michael J. Mitchell,Margaret M. Billingsley,Rebecca M Haley,Marissa E. Wechsler,Nicholas A. Peppas,Robert Langer +5 more
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TLDR
Advances in nanoparticle design that overcome heterogeneous barriers to delivery are discussed, arguing that intelligent nanoparticles design can improve efficacy in general delivery applications while enabling tailored designs for precision applications, thereby ultimately improving patient outcome overall.Abstract:
In recent years, the development of nanoparticles has expanded into a broad range of clinical applications. Nanoparticles have been developed to overcome the limitations of free therapeutics and navigate biological barriers - systemic, microenvironmental and cellular - that are heterogeneous across patient populations and diseases. Overcoming this patient heterogeneity has also been accomplished through precision therapeutics, in which personalized interventions have enhanced therapeutic efficacy. However, nanoparticle development continues to focus on optimizing delivery platforms with a one-size-fits-all solution. As lipid-based, polymeric and inorganic nanoparticles are engineered in increasingly specified ways, they can begin to be optimized for drug delivery in a more personalized manner, entering the era of precision medicine. In this Review, we discuss advanced nanoparticle designs utilized in both non-personalized and precision applications that could be applied to improve precision therapies. We focus on advances in nanoparticle design that overcome heterogeneous barriers to delivery, arguing that intelligent nanoparticle design can improve efficacy in general delivery applications while enabling tailored designs for precision applications, thereby ultimately improving patient outcome overall.read more
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Dissimilar Deformation of Fluid- and Gel-Phase Liposomes upon Multivalent Interaction with Cell Membrane Mimics Revealed Using Dual-Wavelength Surface Plasmon Resonance
TL;DR: It is demonstrated that fluid-phase liposomes are more prone to deformation than their gel-phase counterparts upon binding to the cell membrane mimic and that the degree of deformation depends on the number of ligand–receptor pairs that are engaged in the multivalent binding.
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Applications of Iron Oxide Nanoparticles against Breast Cancer
Hessam Hosseinkazemi,Saeed Samani,Andrew O'Neill,Mahdieh Soezi,Mohsen Moghoofei,M Azhdari,Farzaneh Aavani,Abolfazl Nazbar,Saeed Heidari Keshel,Mohammad Doroudian +9 more
TL;DR: Computerized tomography and magnetic resonance imaging utilizing iron-based magnetic nanoparticles are promising approaches for the radiological detection of breast cancer.
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Tissue engineered drug delivery vehicles: Methods to monitor and regulate the release behavior.
Carmen J. Gil,Lan Li,Boeun Hwang,Melissa Cadena,Andrea S. Theus,Tyler A. Finamore,Holly Bauser-Heaton,Morteza Mahmoudi,Ryan K. Roeder,Vahid Serpooshan +9 more
TL;DR: In this paper , the authors discuss the main mechanisms to tune and monitor/quantify the release kinetics of embedded drugs from engineered scaffolds, and survey the current trend of drug delivery using stimuli driven biopolymer scaffolds to enable precise spatiotemporal control of the release behavior.
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Folic Acid Enables Targeting Delivery of Lipodiscs by Circumventing IgM-Mediated Opsonization.
Huan Wang,Shiqi Lin,Songli Wang,Zhuxuan Jiang,Tianhao Ding,Xiaoli Wei,Ying Lu,Feng Yang,Changyou Zhan +8 more
TL;DR: FA-functionalized lipodiscs (FA-Disc) were constructed to successfully circumvent IgM-mediated opsonization and retained binding activity with folate receptors in vivo, and retained folate binding activity and could effectively target folate receptor positive tumors in vivo.
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Combining Nanotechnology and Gas Plasma as an Emerging Platform for Cancer Therapy: Mechanism and Therapeutic Implication.
TL;DR: In this paper, the authors discuss the recent progress of nanotechnology and gas plasma independently as well as in the concomitant modality of nanoplasma as multimodal platforms with unique capabilities for addressing various therapeutic issues in oncological research.
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