Engineering precision nanoparticles for drug delivery
Michael J. Mitchell,Margaret M. Billingsley,Rebecca M Haley,Marissa E. Wechsler,Nicholas A. Peppas,Robert Langer +5 more
Reads0
Chats0
TLDR
Advances in nanoparticle design that overcome heterogeneous barriers to delivery are discussed, arguing that intelligent nanoparticles design can improve efficacy in general delivery applications while enabling tailored designs for precision applications, thereby ultimately improving patient outcome overall.Abstract:
In recent years, the development of nanoparticles has expanded into a broad range of clinical applications. Nanoparticles have been developed to overcome the limitations of free therapeutics and navigate biological barriers - systemic, microenvironmental and cellular - that are heterogeneous across patient populations and diseases. Overcoming this patient heterogeneity has also been accomplished through precision therapeutics, in which personalized interventions have enhanced therapeutic efficacy. However, nanoparticle development continues to focus on optimizing delivery platforms with a one-size-fits-all solution. As lipid-based, polymeric and inorganic nanoparticles are engineered in increasingly specified ways, they can begin to be optimized for drug delivery in a more personalized manner, entering the era of precision medicine. In this Review, we discuss advanced nanoparticle designs utilized in both non-personalized and precision applications that could be applied to improve precision therapies. We focus on advances in nanoparticle design that overcome heterogeneous barriers to delivery, arguing that intelligent nanoparticle design can improve efficacy in general delivery applications while enabling tailored designs for precision applications, thereby ultimately improving patient outcome overall.read more
Citations
More filters
Journal ArticleDOI
Lipid Nanoparticles-From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement.
TL;DR: Liposomes, an early version of LNPs, are a versatile nanomedicine delivery platform for treatment of a variety of diseases, such as antitumor and nucleic acid therapeutics and vaccine delivery systems as mentioned in this paper.
Journal Article
T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity
Daniela Schmid,Chun Gwon Park,Christina A. Hartl,Nikita Subedi,Adam N.R. Cartwright,Regina Bou Puerto,James Maiarana,Gordon J. Freeman,Kai W. Wucherpfennig,Michael S. Goldberg,Yiran Zheng,Darrell J. Irvine +11 more
TL;DR: PD-1-targeting nanoparticles containing a TGFβ inhibitor or a TLR7/8 agonist are used to deliver these payloads to T cells or via T cells to the tumor microenvironment, leading to anti-tumor efficacy in vivo.
64Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer
Helen Lee,Anthony F. Shields,Barry A. Siegal,Kathy D. Miller,Ian E. Krop,Cynthia X. Ma,Patricia LoRusso,Pamela N. Munster,Karen Campbell,Daniel F. Gaddy,Shannon C. Leonard,Elena Geretti,Stephanie J. Blocker,Dmitri B. Kirpotin,Victor Moyo,Thomas Wickham,Bart S. Hendriks +16 more
TL;DR: Findings provide important evidence and quantification of the EPR effect in human metastatic tumors and support imaging nanoparticle deposition in tumors as a potential means to identify patients well suited for treatment with therapeutic nanoparticles.
Journal ArticleDOI
Role of nanotechnology behind the success of mRNA vaccines for COVID-19.
Amit Khurana,Prince Allawadhi,Isha Khurana,Sachin Allwadhi,Ralf Weiskirchen,Anil Kumar Banothu,Deepak Chhabra,Kamaldeep Joshi,Kala Kumar Bharani +8 more
TL;DR: The emergency use authorization (EUA) by the US-FDA for two mRNA-based vaccines BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) has brought hope of addressing the COVID-19 pandemic which has killed more than two million people globally as mentioned in this paper.
Journal Article
Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems B
TL;DR: It is shown that LNP-siRNA systems can exhibit progressively more bilayer structure as the proportion of bilayer DSPC lipid is increased, suggesting that the core of LNPs can exhibit a continuum of nanostructures depending on the proportions and structural preferences of component lipids.
References
More filters
Journal ArticleDOI
The impact of nanoparticle shape on cellular internalisation and transport: what do the different analysis methods tell us?
TL;DR: This focus article looks at how nanoparticle shape affects cellular internalisation of nanoparticles and what different analysis methods can tell us.
Journal ArticleDOI
Shape effect in active targeting of nanoparticles to inflamed cerebral endothelium under static and flow conditions.
A. Da Silva-Candal,Tyler Brown,Vinu Krishnan,Ignacio López-Loureiro,Paulo Ávila-Gómez,Anusha Pusuluri,Amparo Pérez-Díaz,Clara Correa-Paz,Pablo Hervella,José Castillo,Samir Mitragotri,Francisco Campos +11 more
TL;DR: In this paper, the binding affinity of polystyrene nanoparticles with two different shapes, spherical and rod-shaped, were compared and the effect of particle shape on particle adhesion was also assessed in two in vivo models.
Journal ArticleDOI
Hydrogen-Bonded Tannic Acid-Based Anticancer Nanoparticle for Enhancement of Oral Chemotherapy.
Zhicheng Le,Yantao Chen,Honghua Han,Houkuan Tian,Pengfei Zhao,Chengbiao Yang,Zhiyu He,Lixin Liu,Kam W. Leong,Hai-Quan Mao,Hai-Quan Mao,Zhijia Liu,Yongming Chen +12 more
TL;DR: In vitro and in vivo results confirmed that PTX-NP showed pH-dependent intestinal site-specific drug release, P-gp inhibitory function by tannic acid (TA), prolonged intestinal retention, and improved trans-epithelial transport properties, which confirmed that it might be a promising oral drug formulation for chemotherapy.
Journal ArticleDOI
Silica Nanoparticle as a Lymph Node Targeting Platform for Vaccine Delivery
TL;DR: The results demonstrate that structure-optimized silica nanocarriers can be used as an effective and safe platform for targeted delivery of subunit vaccines and reduce the production of systemic proinflammatory cytokines and completely abrogated splenomegaly.
Journal ArticleDOI
Bioinspired lipoproteins-mediated photothermia remodels tumor stroma to improve cancer cell accessibility of second nanoparticles.
Tao Tan,Tao Tan,Haiyan Hu,Haiyan Hu,Hong Wang,Jie Li,Zhiwan Wang,Jing Wang,Jing Wang,Siling Wang,Zhiwen Zhang,Yaping Li,Yaping Li +12 more
TL;DR: This bLP-mediated TSM-remodeling to enhance cancer cell accessibility (TECA) strategy produces an eminent suppression of tumor growth and results in a 97.4% inhibition of lung metastasis, which is superior to the counterpart liposomes.
Related Papers (5)
Nano based drug delivery systems: recent developments and future prospects
Jayanta Kumar Patra,Gitishree Das,Leonardo Fernandes Fraceto,Leonardo Fernandes Fraceto,Estefania Vangelie Ramos Campos,Estefania Vangelie Ramos Campos,Maria del Pilar Rodriguez-Torres,Laura Susana Acosta-Torres,Luis A. Diaz-Torres,Renato Grillo,Mallappa Kumara Swamy,Shivesh Sharma,Solomon Habtemariam,Han-Seung Shin +13 more