Engineering precision nanoparticles for drug delivery
Michael J. Mitchell,Margaret M. Billingsley,Rebecca M Haley,Marissa E. Wechsler,Nicholas A. Peppas,Robert Langer +5 more
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TLDR
Advances in nanoparticle design that overcome heterogeneous barriers to delivery are discussed, arguing that intelligent nanoparticles design can improve efficacy in general delivery applications while enabling tailored designs for precision applications, thereby ultimately improving patient outcome overall.Abstract:
In recent years, the development of nanoparticles has expanded into a broad range of clinical applications. Nanoparticles have been developed to overcome the limitations of free therapeutics and navigate biological barriers - systemic, microenvironmental and cellular - that are heterogeneous across patient populations and diseases. Overcoming this patient heterogeneity has also been accomplished through precision therapeutics, in which personalized interventions have enhanced therapeutic efficacy. However, nanoparticle development continues to focus on optimizing delivery platforms with a one-size-fits-all solution. As lipid-based, polymeric and inorganic nanoparticles are engineered in increasingly specified ways, they can begin to be optimized for drug delivery in a more personalized manner, entering the era of precision medicine. In this Review, we discuss advanced nanoparticle designs utilized in both non-personalized and precision applications that could be applied to improve precision therapies. We focus on advances in nanoparticle design that overcome heterogeneous barriers to delivery, arguing that intelligent nanoparticle design can improve efficacy in general delivery applications while enabling tailored designs for precision applications, thereby ultimately improving patient outcome overall.read more
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Oxidative Precipitation Synthesis of Calcium-Doped Manganese Ferrite Nanoparticles for Magnetic Hyperthermia
Sérgio Rafael Silva Veloso,Raquel G. D. Andrade,Valéria Gomes,Carlos O. Amorim,Vitor S. Amaral,Verónica Salgueiriño,Paulo J. G. Coutinho,Paula Ferreira,Miguel A. Correa-Duarte,Elisabete M. S. Castanheira +9 more
TL;DR: In this article , the authors synthesize superparamagnetic nanoparticles of calcium-doped manganese ferrites (CaxMn1−xFe2O4) functionalized with citrate through thermally assisted oxidative precipitation in aqueous media.
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Hong Luo,Hao Zhang,Jin Ning Mao,Hui Cao,Yihao Tao,Guanjian Zhao,Zhiwen Zhang,Nan Zhang,Zao-bin Liu,Jian Zhang,Peng Luo,Yuguo Xia,Yuan Cheng,Zongyi Xie,Quan Cheng,Guodong Liu +15 more
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BSA-magnetite nanotorpedo for safe and efficient delivery of chemotherapy drugs
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TL;DR: In this article , a BSA-magnetite nanotorpedo (BMNT) was designed to solve the leakage problem of hydrophobic drug molecules, and prolonged their half-life in blood circulation, achieving efficient antitumor efficacy.
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