Enteric Tuft Cells in Host-Parasite Interactions.
TLDR
In this article, the authors highlight the versatility of enteric tuft cells and sub-types thereof, showcasing nuances of tuft cell responses to different parasites, with a focus on helminths reflecting the current state of the field.Abstract:
Enteric tuft cells are chemosensory epithelial cells gaining attention in the field of host-parasite interactions. Expressing a repertoire of chemosensing receptors and mediators, these cells have the potential to detect lumen-dwelling helminth and protozoan parasites and coordinate epithelial, immune, and neuronal cell defenses against them. This review highlights the versatility of enteric tuft cells and sub-types thereof, showcasing nuances of tuft cell responses to different parasites, with a focus on helminths reflecting the current state of the field. The role of enteric tuft cells in irritable bowel syndrome, inflammatory bowel disease and intestinal viral infection is assessed in the context of concomitant infection with parasites. Finally, the review presents pertinent questions germane to understanding the enteric tuft cell and its role in enteric parasitic infections. There is much to be done to fully elucidate the response of this intriguing cell type to parasitic-infection and there is negligible data on the biology of the human enteric tuft cell—a glaring gap in knowledge that must be filled.read more
Citations
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Sirtuin 6 maintains epithelial STAT6 activity to support intestinal tuft cell development and type 2 immunity
Xiwen Xiong,Chenyan Yang,Weiqi He,Jiahui Yu,Yue-Yang Xin,Xinge Zhang,Rong-Zeng Huang,Honghui Ma,Shaofang Xu,Zun Li,Jie Ma,Lin Xu,Qunyi Wang,Kaiqun Ren,Xiaoli S. Wu,Christopher R. Vakoc,Jiateng Zhong,Genshen Zhong,Xiaofei Zhu,Yu Song,Hai Bin Ruan,Qingzhi Wang +21 more
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